Adrenergic Antagonists Quiz
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Questions and Answers

Which medication is an alpha 1 antagonist and a weak beta 1 antagonist?

  • Trazodone
  • Indoramine (correct)
  • Urapidil
  • Chlorpromazine

    • Which medication is used for the palliative treatment of benign prostatic hypertrophy?

  • Reserpine
  • Prazosin
  • Guanetidin
  • Doxazosin (correct)

    • Which medication is an adrenergic neuron blocker used in the treatment of hypertension and vasospastic diseases?

  • Bethanidine
  • Methyrosine
  • Debrisoquin (correct)
  • Guanadrel

    • Which medication inhibits adrenergic mediator release by reducing noradrenaline, dopamine, and serotonin synthesis?

    <p>Tyrosine hydroxylase</p> Signup and view all the answers

    Which drug can cause postural hypotension as a significant effect?

    <p>Guanetidine</p> Signup and view all the answers

    Which type of adrenergic receptor blockers can generate postural hypotension?

    <p>Adrenergic neuron blockers</p> Signup and view all the answers

    Which drug has no significant effect on the heart but can increase sympathetic activity?

    <p>Phentolamine</p> Signup and view all the answers

    Which adrenergic receptor blocker can cause myosis and block pilomotor contraction?

    <p>Phenoxybenzamine</p> Signup and view all the answers

    Which drug can reverse the effect of adrenaline (α and β)?

    <p>Phentolamine</p> Signup and view all the answers

    Which drug reduces kidney blood flow and causes water and salt retention?

    <p>Prazosine</p> Signup and view all the answers

    Which type of adrenergic receptor blockers removes sympathetic tone and vasodilates in vascular beds?

    <p>Alpha adrenergic receptor blockers</p> Signup and view all the answers

    Which drug blocks the secretion of apocrine sweat glands?

    <p>Phenoxybenzamine</p> Signup and view all the answers

    Which type of blocker is phenoxybenzamine?

    <p>Irreversible alpha adrenergic blocker</p> Signup and view all the answers

    What is the clinical use of dihydroergotamin maleate?

    <p>Treatment of migraines that do not respond to analgesic drugs</p> Signup and view all the answers

    What are the side effects and contraindications of ergot alkaloids?

    <p>Nausea, vomiting, and can cause chronic ergot poisoning (ergotism)</p> Signup and view all the answers

    What are the clinical uses of prazosin and its analogues?

    <p>Selective alpha 1 blockers used in hypertension and benign prostatic hypertrophy</p> Signup and view all the answers

    What are the pharmacological effects of ergot alkaloids?

    <p>Multiple effects on smooth muscles, blood pressure, serotonin, and alpha-adrenergic receptors</p> Signup and view all the answers

    What are the clinical uses of ergotamine tartrate?

    <p>Powerful vasoconstrictor used for treating migraine attacks</p> Signup and view all the answers

    What is the pharmacological effect of labetolol?

    <p>Both an alpha and beta blocker, with a stronger beta-blocker effect</p> Signup and view all the answers

    What are the side effects of prazosin and similar alpha blockers?

    <p>First-dose syncope and tachyphylaxis over time</p> Signup and view all the answers

    What type of blocker is carvedilol?

    <p>Both an alpha and beta blocker, with a stronger beta-blocker effect</p> Signup and view all the answers

    What are the clinical uses of dihydroergotamin maleate?

    <p>Treatment of migraines that do not respond to analgesic drugs</p> Signup and view all the answers

    Which of the following is a side effect of prazosin and similar alpha blockers?

    <p>First-dose syncope</p> Signup and view all the answers

    Which medication is used for treating migraine attacks and is available in combination with caffeine?

    <p>Ergotamine tartrate</p> Signup and view all the answers

    What is the pharmacological effect of labetolol?

    <p>Alpha and beta blocking</p> Signup and view all the answers

    Which drug is an irreversible blocker of alpha adrenergic receptors?

    <p>Phenoxybenzamine</p> Signup and view all the answers

    What are the clinical uses of dihydroergotamin maleate?

    <p>Treatment of migraines that do not respond to analgesic drugs</p> Signup and view all the answers

    Which drug has a stronger beta-blocker effect and is used in mild-severe hypertension?

    <p>Labetolol</p> Signup and view all the answers

    Which medication is a selective alpha 1 blocker used in hypertension and benign prostatic hypertrophy?

    <p>Prazosin</p> Signup and view all the answers

    Which drug is used for migraines that do not respond to analgesic drugs?

    <p>Dihydroergotamin maleate</p> Signup and view all the answers

    Which drug causes chronic ergot poisoning (ergotism) as a side effect?

    <p>Ergotamine tartrate</p> Signup and view all the answers

    Which medication should periodic eye examination be performed during treatment due to its collection in the choroidal layer?

    <p>Labetolol</p> Signup and view all the answers

    Which drug can cause myosis and block pilomotor contraction?

    <p>Phentolamine</p> Signup and view all the answers

    Which medication is an alpha 1 antagonist and a weak beta 1 antagonist?

    <p>Carvedilol</p> Signup and view all the answers

    What type of adrenergic receptor blockers removes sympathetic tone and vasodilates in vascular beds?

    <p>Labetolol</p> Signup and view all the answers

    Which adrenergic receptor blocker can generate postural hypotension?

    <p>Doxazosin</p> Signup and view all the answers

    What are the pharmacological effects of ergot alkaloids?

    <p>Vasodilation and increased sympathetic activity</p> Signup and view all the answers

    What are the clinical uses of guanetidine and similar adrenergic neuron blockers?

    <p>Hypertension and pheochromocytoma</p> Signup and view all the answers

    Which drug is an alpha 1 antagonist, weak alpha 2 agonist, and 5-HT1A-agonist, and also a weak beta1 antagonist?

    <p>Indoramine</p> Signup and view all the answers

    Which medication is used for the palliative treatment of benign prostatic hypertrophy?

    <p>Doxazosin</p> Signup and view all the answers

    Which drug is an adrenergic neuron blocker used in the treatment of hypertension and vasospastic diseases?

    <p>Guanadrel</p> Signup and view all the answers

    Which medication inhibits adrenergic mediator release by reducing noradrenaline, dopamine, and serotonin synthesis?

    <p>Methyrosine (α methyl-p-tyrosine)</p> Signup and view all the answers

    Which drug is used in the treatment of pheochromocytoma or as premedication before surgery?

    <p>Methyrosine (α methyl-p-tyrosine)</p> Signup and view all the answers

    Which drug is a 1 antagonist α haloperidol antipsychotic and an antagonist of dopamine?

    <p>Chlorpromazine</p> Signup and view all the answers

    Which medication is used for the treatment of congestive heart failure (not preferred)?

    <p>Prazosin</p> Signup and view all the answers

    Which drug is used for the prevention of vasospasm in open heart and kidney transplant surgeries?

    <p>Urapidil</p> Signup and view all the answers

    Which medication is used for the treatment of peripheral vascular diseases due to sympathetic activity?

    <p>Rauwolfia alkaloids (e.g., Reserpine)</p> Signup and view all the answers

    Which drug is an alpha 1 antagonist used in the treatment of hypertension due to overdose of sympathomimetic drugs?

    <p>Prazosin</p> Signup and view all the answers

    Study Notes

    Pharmacological Effects and Clinical Use of Alpha Adrenergic Blockers

    • Phenoxybenzamine irreversibly blocks alpha adrenergic receptors and is not marketed in Turkey.
    • Ergot alkaloids, found in ergot formed by the fungus Claviceps purpurea, have multiple pharmacological effects on smooth muscles, blood pressure, serotonin, and alpha-adrenergic receptors.
    • Ergotamine tartrate is a powerful vasoconstrictor used for treating migraine attacks and is available in combination with caffeine.
    • Dihydroergotamin maleate is used for migraines that do not respond to analgesic drugs and in the treatment of deep vein thrombosis.
    • Side effects and contraindications of ergot alkaloids include nausea, vomiting, and can cause chronic ergot poisoning (ergotism).
    • 3-Phentolamine and tolazoline are short-acting partial agonists on alpha-receptors.
    • Prazosin and its analogues, such as terazosin and doxazosin, are selective alpha 1 blockers used in hypertension and benign prostatic hypertrophy.
    • Prazosin causes hypotension, tolerance, and is also useful in congestive heart failure and Raynaud's syndrome.
    • Labetolol is both an alpha and beta blocker, with a stronger beta-blocker effect, and is used in mild-severe hypertension.
    • Carvedilol is another hybrid blocker with both alpha and beta-blocking effects.
    • Prazosin and similar alpha blockers have side effects such as first-dose syncope and tachyphylaxis over time.
    • Periodic eye examination should be performed during labetolol treatment due to its collection in the choroidal layer.

    Pharmacological Effects and Clinical Use of Alpha Adrenergic Blockers

    • Phenoxybenzamine irreversibly blocks alpha adrenergic receptors and is not marketed in Turkey.
    • Ergot alkaloids, found in ergot formed by the fungus Claviceps purpurea, have multiple pharmacological effects on smooth muscles, blood pressure, serotonin, and alpha-adrenergic receptors.
    • Ergotamine tartrate is a powerful vasoconstrictor used for treating migraine attacks and is available in combination with caffeine.
    • Dihydroergotamin maleate is used for migraines that do not respond to analgesic drugs and in the treatment of deep vein thrombosis.
    • Side effects and contraindications of ergot alkaloids include nausea, vomiting, and can cause chronic ergot poisoning (ergotism).
    • 3-Phentolamine and tolazoline are short-acting partial agonists on alpha-receptors.
    • Prazosin and its analogues, such as terazosin and doxazosin, are selective alpha 1 blockers used in hypertension and benign prostatic hypertrophy.
    • Prazosin causes hypotension, tolerance, and is also useful in congestive heart failure and Raynaud's syndrome.
    • Labetolol is both an alpha and beta blocker, with a stronger beta-blocker effect, and is used in mild-severe hypertension.
    • Carvedilol is another hybrid blocker with both alpha and beta-blocking effects.
    • Prazosin and similar alpha blockers have side effects such as first-dose syncope and tachyphylaxis over time.
    • Periodic eye examination should be performed during labetolol treatment due to its collection in the choroidal layer.

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    ADRENERGIC ANTAGONISTS.ppt

    Description

    Test your knowledge of adrenergic antagonist drugs and their classifications. Learn about alpha and beta adrenergic receptor blockers, as well as other sympatholytic drugs.

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