Pharmacology of Anti-Platelet Drugs

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Questions and Answers

What is the mechanism of acetylsalicylic acid (aspirin) in anti-platelet therapy?

Inhibition of Thromboxane A2 (correct)

P2Y12 antagonism

Stimulation of platelet aggregation

GPIIb/IIIa inhibition

How many mechanisms do anti-platelet drugs work on?

4 (correct)

What is the target of P2Y12 antagonists in anti-platelet therapy?

GPIIb/IIIa

P2Y12 receptors (correct)

Platelet surface

Thromboxane A2

GPIIb/IIIa inhibitors have how many effects in anti-platelet therapy?

2 Signup and view all the answers

What is the overall goal of anti-platelet therapy?

To inhibit platelet activation Signup and view all the answers

What is the primary benefit of anti-platelet therapy in patients with prosthetic heart valves?

Inhibition of embolization Signup and view all the answers

In which type of patients is anti-platelet therapy particularly important?

Those with prosthetic heart valves Signup and view all the answers

What is the consequence of inadequate anti-platelet therapy in patients with prosthetic heart valves?

Higher risk of embolization Signup and view all the answers

What is the primary goal of anti-platelet therapy in patients with prosthetic heart valves?

To prevent platelet aggregation Signup and view all the answers

Why is anti-platelet therapy important in patients with prosthetic heart valves?

To prevent the formation of blood clots Signup and view all the answers

What is the classification of Dipyridamole?

Anti-platelet Signup and view all the answers

What is the purpose of Dipyridamole?

To prevent blood clots Signup and view all the answers

Which of the following is NOT a characteristic of Dipyridamole?

Increases platelet count Signup and view all the answers

What is the effect of Dipyridamole on platelet activity?

Inhibits platelet activation Signup and view all the answers

What type of medication is Dipyridamole?

Anti-platelet Signup and view all the answers

What is the optimal dose of the medication?

80mg Signup and view all the answers

What is the effect of high doses of the medication on COX-2?

It inhibits COX-2 Signup and view all the answers

Why are higher doses of the medication potentially less efficacious?

Because they inhibit COX-2 Signup and view all the answers

What is the effect of higher doses of the medication on toxicity?

It increases toxicity, especially bleeding Signup and view all the answers

What is prostacyclin responsible for?

Inhibiting platelet aggregation Signup and view all the answers

What is a common adverse effect of Ticlopidine?

Decrease in WBC Signup and view all the answers

What is the dose of Ticlopidine?

250 mg BD Signup and view all the answers

Which of the following is NOT an adverse effect of Ticlopidine?

Headache Signup and view all the answers

What class of anti-platelet drugs do Ticlopidine and Clopidogrel belong to?

ADP antagonists Signup and view all the answers

Which of the following is a safer option than Ticlopidine?

Clopidogrel Signup and view all the answers

Study Notes

Anti-Platelet Drugs

To give anti-platelet drugs, four mechanisms are targeted:
- Acetylsalicylic acid (aspirin) as an inhibitor of Thromboxane A2
- P2Y12 antagonists
- GPIIb/IIIa antagonists
- Dipyridamole

Mechanism of Acetylsalicylic Acid (Aspirin)

Works as an inhibitor of Thromboxane A2
At high doses (1g/d), also inhibits COX-2, responsible for synthesizing prostacyclin
High doses are potentially less efficacious and increase toxicity, especially bleeding
In patients with prosthetic valves, it inhibits embolization

Comparing Clopidogrel and Ticlopidine

Clopidogrel is safer than Ticlopidine
Ticlopidine has adverse effects, including:
- Diarrhea
- Vomiting
- Abdominal pain
- Decrease in WBC

Dipyridamole

Has two effects: anti-platelet and maximal effective dose of 50-320 mg (optimal dose = 80mg)

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Description

This quiz covers the mechanisms of action of anti-platelet drugs, including acetylsalicylic acid and P2Y12 antagonists.