25 Questions
What is the mechanism of acetylsalicylic acid (aspirin) in anti-platelet therapy?
Inhibition of Thromboxane A2
How many mechanisms do anti-platelet drugs work on?
4
What is the target of P2Y12 antagonists in anti-platelet therapy?
P2Y12 receptors
GPIIb/IIIa inhibitors have how many effects in anti-platelet therapy?
2
What is the overall goal of anti-platelet therapy?
To inhibit platelet activation
What is the primary benefit of anti-platelet therapy in patients with prosthetic heart valves?
Inhibition of embolization
In which type of patients is anti-platelet therapy particularly important?
Those with prosthetic heart valves
What is the consequence of inadequate anti-platelet therapy in patients with prosthetic heart valves?
Higher risk of embolization
What is the primary goal of anti-platelet therapy in patients with prosthetic heart valves?
To prevent platelet aggregation
Why is anti-platelet therapy important in patients with prosthetic heart valves?
To prevent the formation of blood clots
What is the classification of Dipyridamole?
Anti-platelet
What is the purpose of Dipyridamole?
To prevent blood clots
Which of the following is NOT a characteristic of Dipyridamole?
Increases platelet count
What is the effect of Dipyridamole on platelet activity?
Inhibits platelet activation
What type of medication is Dipyridamole?
Anti-platelet
What is the optimal dose of the medication?
80mg
What is the effect of high doses of the medication on COX-2?
It inhibits COX-2
Why are higher doses of the medication potentially less efficacious?
Because they inhibit COX-2
What is the effect of higher doses of the medication on toxicity?
It increases toxicity, especially bleeding
What is prostacyclin responsible for?
Inhibiting platelet aggregation
What is a common adverse effect of Ticlopidine?
Decrease in WBC
What is the dose of Ticlopidine?
250 mg BD
Which of the following is NOT an adverse effect of Ticlopidine?
Headache
What class of anti-platelet drugs do Ticlopidine and Clopidogrel belong to?
ADP antagonists
Which of the following is a safer option than Ticlopidine?
Clopidogrel
Study Notes
Anti-Platelet Drugs
- To give anti-platelet drugs, four mechanisms are targeted:
- Acetylsalicylic acid (aspirin) as an inhibitor of Thromboxane A2
- P2Y12 antagonists
- GPIIb/IIIa antagonists
- Dipyridamole
Mechanism of Acetylsalicylic Acid (Aspirin)
- Works as an inhibitor of Thromboxane A2
- At high doses (1g/d), also inhibits COX-2, responsible for synthesizing prostacyclin
- High doses are potentially less efficacious and increase toxicity, especially bleeding
- In patients with prosthetic valves, it inhibits embolization
Comparing Clopidogrel and Ticlopidine
- Clopidogrel is safer than Ticlopidine
- Ticlopidine has adverse effects, including:
- Diarrhea
- Vomiting
- Abdominal pain
- Decrease in WBC
Dipyridamole
- Has two effects: anti-platelet and maximal effective dose of 50-320 mg (optimal dose = 80mg)
This quiz covers the mechanisms of action of anti-platelet drugs, including acetylsalicylic acid and P2Y12 antagonists.
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