Adrenal Glands and Hormones
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Questions and Answers

What is the percentage of the total size of the adrenal glands that is composed of the adrenal cortex?

  • 90% (correct)
  • 75%
  • 80%
  • 10%

What is the primary precursor for the production of hormones in the adrenal cortex?

  • Pregnenolone
  • Cortisol
  • Aldosterone
  • Cholesterol (correct)

Which hormone is responsible for regulating the secretion of adrenal glucocorticoids and androgens?

  • Aldosterone
  • ACTH (correct)
  • RAAS
  • CRH

What is the function of the zona glomerulosa layer of the adrenal cortex?

<p>Principal source of mineralocorticoids (A)</p> Signup and view all the answers

What is the significance of the renin-angiotensin-aldosterone system (RAAS)?

<p>Control of mineralocorticoid secretion (D)</p> Signup and view all the answers

What is the structure of the adrenal glands?

<p>Pyramid-like shape (B)</p> Signup and view all the answers

What percentage of the adrenal cortex is composed of the zona reticularis?

<p>15% (D)</p> Signup and view all the answers

Which of the following hormones is produced by the zona fasciculata?

<p>Cortisol (A)</p> Signup and view all the answers

What is the primary effect of cortisol on glucose metabolism?

<p>Stimulates lipolysis and gluconeogenesis (A)</p> Signup and view all the answers

What is the primary regulator of cortisol synthesis?

<p>ACTH (D)</p> Signup and view all the answers

What is the typical diurnal pattern of cortisol secretion?

<p>Highest levels in the morning, lowest levels at night (C)</p> Signup and view all the answers

What is the primary use of cortisol in therapeutic settings?

<p>Treatment of autoimmune disorders (A)</p> Signup and view all the answers

What is the characteristic of SCNN1B gene mutation?

<p>Increase activity of the Epithelial sodium channel (B)</p> Signup and view all the answers

What is the defect associated with Gitelman's Syndrome?

<p>Thiazide sensitive transporter mutation (A)</p> Signup and view all the answers

What is the test used to diagnose hypoaldosteronism?

<p>Furosemide Stimulation Test (B)</p> Signup and view all the answers

What is the hormone regulated by ACTH that serves as a precursor for the production of more potent androgens and estrogens in tissues?

<p>Dehydroepiandrosterone (DHEA) (B)</p> Signup and view all the answers

What is the condition characterized by hyperkalemia and metabolic acidosis?

<p>Hypoaldosteronism (C)</p> Signup and view all the answers

What is the synthetic mineralocorticoid used to treat hypoaldosteronism?

<p>Florinef (A)</p> Signup and view all the answers

What is the primary effect of excessive androgen production in women and children?

<p>Virilization (C)</p> Signup and view all the answers

What is the primary function of norepinephrine in the body?

<p>Acting as a neurotransmitter in the CNS and sympathetic nervous system (D)</p> Signup and view all the answers

What is the ratio of norepinephrine to epinephrine in serum?

<p>9:1 (D)</p> Signup and view all the answers

What is the major metabolite of dopamine in the urine?

<p>Homovanillic acid (C)</p> Signup and view all the answers

What is the primary characteristic of pheochromocytoma?

<p>A tumor of the adrenal medulla or sympathetic ganglia (C)</p> Signup and view all the answers

What is the result of secondary hypocortisolism on cortisol and ACTH levels?

<p>Decreased cortisol and decreased ACTH (A)</p> Signup and view all the answers

What is the primary use of the measurement of plasma metanephrines and normetanephrines in the diagnosis of pheochromocytoma?

<p>As a screening test (D)</p> Signup and view all the answers

What is the purpose of the Metyrapone Test?

<p>To measure the ability of the pituitary gland to respond to declining levels of circulating cortisol (B)</p> Signup and view all the answers

What is the most sensitive and specific screening test for excess cortisol production?

<p>24 hour urinary free cortisol (D)</p> Signup and view all the answers

What is the result of congenital adrenal hyperplasia on cortisol and ACTH levels?

<p>Decreased cortisol and increased ACTH (A)</p> Signup and view all the answers

What is the gold standard for confirming secondary and tertiary hypocortisolism?

<p>Insulin Tolerance Test (C)</p> Signup and view all the answers

What is the current reference method for measuring urinary free cortisol?

<p>HPLC-MS (B)</p> Signup and view all the answers

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