Adrenal Gland Dysfunction: Pathology and Diagnosis
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Questions and Answers

What is the percentage of aldosterone-producing adrenal cortical adenoma in primary aldosteronism?

  • 30%
  • 40%
  • 25%
  • 35% (correct)

Which of the following mutations is most commonly associated with aldosterone-producing adrenal cortical adenoma?

  • ATP1A1
  • KCNJ5 (correct)
  • KCNJ3
  • CACNA1D

What percentage of primary aldosteronism is due to familial hyperaldosteronism?

  • 5% (correct)
  • 3%
  • 2%
  • 10%

What is the result of activation of aldosterone synthase in aldosterone-producing adrenal cortical adenoma?

<p>Autonomous aldosterone synthesis (B)</p> Signup and view all the answers

What is the name of the syndrome caused by bilateral idiopathic hyperaldosteronism?

<p>Conn's syndrome (A)</p> Signup and view all the answers

What is the percentage of bilateral idiopathic hyperaldosteronism in primary aldosteronism?

<p>60% (A)</p> Signup and view all the answers

What is the name of the gene mutated in some cases of familial hyperaldosteronism?

<p>None of the above (D)</p> Signup and view all the answers

What is the name of the journal that published the article on primary aldosteronism?

<p>Nature Reviews Endocrinology (B)</p> Signup and view all the answers

What is the characteristic of aldosterone-producing adenomas in terms of size?

<p>Small, ranging from 1-32 mm in diameter (A)</p> Signup and view all the answers

What is the primary function of the renin-angiotensin system in relation to hyperaldosteronism?

<p>To activate the juxtaglomerular cells (A)</p> Signup and view all the answers

What is the characteristic of cells in aldosterone-producing adenomas?

<p>Lipid-rich and compact (C)</p> Signup and view all the answers

What is the most common cause of secondary hyperaldosteronism?

<p>Poor renal perfusion (D)</p> Signup and view all the answers

What is the effect of hyperaldosteronism on blood potassium levels?

<p>Decreased potassium levels (C)</p> Signup and view all the answers

What is the effect of hyperaldosteronism on blood sodium levels?

<p>Increased sodium levels (A)</p> Signup and view all the answers

What is the characteristic of hyperaldosteronism in terms of blood pressure?

<p>Increased blood pressure (C)</p> Signup and view all the answers

What is the effect of hyperaldosteronism on blood pH?

<p>Alkalosis (C)</p> Signup and view all the answers

Which of the following is responsible for producing aldosterone?

<p>Zona glomerulosa (D)</p> Signup and view all the answers

What is the primary characteristic of primary hyperaldosteronism?

<p>Autonomous overproduction of aldosterone (B)</p> Signup and view all the answers

Which of the following is the most common cause of primary hyperaldosteronism?

<p>Bilateral idiopathic hyperaldosteronism (A)</p> Signup and view all the answers

What is the primary function of the adrenal medulla?

<p>To produce epinephrine and norepinephrine (B)</p> Signup and view all the answers

What is the primary effect of hyperaldosteronism on the body?

<p>Hypertension due to increased reabsorption of sodium and water (D)</p> Signup and view all the answers

Which of the following is a characteristic of familial hyperaldosteronism?

<p>It is a rare genetic condition (B)</p> Signup and view all the answers

What is the primary difference between bilateral idiopathic hyperaldosteronism and aldosterone-producing adrenal cortical adenoma?

<p>Bilateral idiopathic hyperaldosteronism is associated with a bilateral mass, while aldosterone-producing adrenal cortical adenoma is associated with unilateral hyperplasia (D)</p> Signup and view all the answers

What is the role of the zona reticularis in the adrenal cortex?

<p>To produce androgens (B)</p> Signup and view all the answers

What is the primary purpose of measuring cortisol levels in diagnosing Cushing's syndrome?

<p>To identify hypersecretion of ACTH (B)</p> Signup and view all the answers

What is the implication of high cortisol levels with normal or low ACTH levels in Cushing's syndrome?

<p>Adrenal neoplasms are likely (C)</p> Signup and view all the answers

What is the purpose of the dexamethasone suppression test in diagnosing Cushing's syndrome?

<p>To distinguish between pituitary microadenoma and adrenal neoplasms (D)</p> Signup and view all the answers

What is the recommended treatment for pituitary microadenoma in Cushing's syndrome?

<p>Surgical resection of the tumor (C)</p> Signup and view all the answers

What is the risk of sudden withdrawal of exogenous medications in Cushing's syndrome?

<p>Adrenal crisis (B)</p> Signup and view all the answers

What is the role of imaging studies in diagnosing Cushing's syndrome?

<p>To localize pituitary and adrenal tumors (A)</p> Signup and view all the answers

What is the primary goal of treatment in Cushing's syndrome?

<p>To eliminate the tumor (D)</p> Signup and view all the answers

What medications are used to treat adrenal adenoma or carcinoma in Cushing's syndrome?

<p>Ketoconazole and metyrapone (B)</p> Signup and view all the answers

What is the primary purpose of an adrenal saline suppression test in diagnosing hyperaldosteronism?

<p>To determine the location of an adrenal adenoma (B)</p> Signup and view all the answers

What is the effect of excessive cortisol production on the immune system?

<p>Suppression of the immune system (D)</p> Signup and view all the answers

What is the primary function of cortisol in regulating blood pressure?

<p>To increase blood pressure (A)</p> Signup and view all the answers

What is the primary difference between primary and secondary hyperaldosteronism?

<p>The underlying etiology of the condition (A)</p> Signup and view all the answers

What is the typical presentation of Cushing's syndrome?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary treatment for an adrenal adenoma causing primary hyperaldosteronism?

<p>Adrenalectomy (B)</p> Signup and view all the answers

What is the effect of excessive cortisol production on ovarian and testicular functions?

<p>Suppression of ovarian and testicular functions (B)</p> Signup and view all the answers

What is the primary function of cortisol in regulating circadian rhythm?

<p>To regulate the sleep-wake cycle (D)</p> Signup and view all the answers

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