Adrenal Cortex Hormone Disorders Diagnosis

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Questions and Answers

What is a possible cause of adrenal failure in boys?

Allgrove’s syndrome

Pseudo hypo aldosteronism type 2 (Gordon’s syndrome)

Abnormalities of β-oxidation of VLCFAs (correct)

Pseudo hypoaldosteronism type 1

What is the main focus of clinical chemistry 1 learning objectives related to adrenal cortex?

Studying the role of adrenal cortex in electrolyte balance

Diagnosing other types of adrenal cortex hormone hypo & hyper secretion disease (correct)

Understanding the structure of the adrenal cortex

Analyzing the impact of adrenal cortex on other organs

What is a characteristic feature of Pseudo hypoaldosteronism type 1?

Salt wasting associated with hypotension (correct)

Autosomal dominant condition

Mild hyperchloremic acidosis

Elevations in plasma renin and aldosterone

What are the characteristic features of Pseudo hypo aldosteronism type 2 (Gordon’s syndrome)?

Hyperkalaemia, hypertension, and mild hyperchloremic acidosis Signup and view all the answers

Match the following adrenal cortex hormone disorders with their respective characteristics:

Congenital adrenal hyperplasia = Pathophysiology & causes demonstration Primary hyper aldosteronism = Definition, types, diagnosis, treatment Hypoadrenalism = Causes and associated conditions Pseudo hypoaldosteronism type 1 = Presentation, associated features, and treatment Signup and view all the answers

Match the following causes of hypoadrenalism with their respective conditions:

Hypoaldosteronism hyporeninism = Association with type 2 DM and type IV renal tubular acidosis Abnormalities of β-oxidation of VLCFAs = X-linked recessive defects and accumulation in tissues Allgrove’s syndrome = Congenital adrenocortical unresponsiveness to ACTH Pseudo hypo aldosteronism type 2 (Gordon’s syndrome) = Characteristics and inheritance pattern Signup and view all the answers

Match the following conditions with their characteristic features in Pseudo hypoaldosteronism type 1:

Failure to thrive and salt wasting = Presentation in infancy Hypotension, hyperkalaemia, large elevations in plasma renin and aldosterone = Associated clinical features Defects in the epithelial sodium channel or mineralocorticoid receptor = Underlying defects High sodium diet and high-dose fludrocortisone or carbenoxolone = Recommended treatment Signup and view all the answers

Match the following conditions with their characteristic features in Pseudo hypo adrenalism (Gordon’s syndrome):

Autosomal dominant condition = Inheritance pattern Hyperkalaemia, hypertension, mild hyper chloraemic acidosis = Representative clinical features Signup and view all the answers

Types of tests use for diagnosis:

ACTH stimulation test, 24-hour urine cortisol measurement, dexamethasone suppression test Signup and view all the answers

Rarer cause of hypoadrenalism is ______ due to congenital adrenocortical unresponsiveness to ACTH.

Allgrove’s syndrome Signup and view all the answers

Pseudo hypo aldosteronism type 2, or ______, is an autosomal dominant condition. Represent by hyperkalaemia, hypertension and a mild hyper chloraemic acidosis.

Gordon’s syndrome Signup and view all the answers

______ hyporeninism is associated with type 2 DM and type IV renal tubular acidosis.

Hypoaldosteronism Signup and view all the answers

______ usually presents in infancy with failure to thrive and salt wasting associated with hypotension, hyperkalaemia and large elevations in plasma renin and aldosterone.

Pseudo hypoaldosteronism type 1 Signup and view all the answers

Study Notes

Adrenal Failure in Boys

A possible cause of adrenal failure in boys is congenital adrenocortical unresponsiveness to ACTH.

Clinical Chemistry 1 Learning Objectives

The main focus of clinical chemistry 1 learning objectives related to adrenal cortex is understanding the functions and disorders of the adrenal cortex, particularly the adrenal cortex hormones.

Pseudo Hypoaldosteronism Type 1

A characteristic feature of Pseudo Hypoaldosteronism Type 1 is that it usually presents in infancy with failure to thrive and salt wasting associated with hypotension, hyperkalemia, and large elevations in plasma renin and aldosterone.

Pseudo Hypoaldosteronism Type 2 (Gordon's Syndrome)

Characteristic features of Pseudo Hypoaldosteronism Type 2 include hyperkalemia, hypertension, and a mild hyperchloremic acidosis, and it is an autosomal dominant condition.