Adrenal Cortex Hormone Biosynthesis
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Questions and Answers

Where is aldosterone exclusively synthesized?

  • Zona fasciculata
  • Z.Glomerulosa (correct)
  • Adrenal medulla
  • Zona reticularis

What is the function of the steroidogenic acute regulatory protein (StAR)?

  • To synthesize aldosterone
  • To regulate cortisol production
  • To carry cholesterol to the inner mitochondrial membrane (correct)
  • To convert cholesterol to pregnenolone

What is the rate-limiting step in steroid hormone biosynthesis?

  • The synthesis of cortisol
  • The hydroxylation at the 17-alpha position
  • The conversion of pregnenolone to progesterone
  • The cleavage of the side chain of cholesterol by cytochrome P450 side chain cleavage enzyme (correct)

What is the common precursor for all other steroids?

<p>Pregnenolone (B)</p> Signup and view all the answers

What is the primary function of aldosterone?

<p>To promote sodium retention and potassium elimination by the kidney (A)</p> Signup and view all the answers

Which of the following is the primary regulator of electrolyte balance and extracellular fluid volume?

<p>Aldosterone (C)</p> Signup and view all the answers

What is the resulting problem in Primary Hyperaldosteronism (Conn’s syndrome)?

<p>Hypertension and edema (C)</p> Signup and view all the answers

What is the primary stimulus for aldosterone secretion?

<p>Angiotensin II (A)</p> Signup and view all the answers

What is the purpose of measuring plasma aldosterone/renin ratio?

<p>To screen for excessive aldosterone secretion (A)</p> Signup and view all the answers

What is the primary function of glucocorticoid receptors?

<p>Regulate gene transcription (A)</p> Signup and view all the answers

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