Acute vs. Chronic Hepatitis Comparison
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Questions and Answers

Which enzyme is responsible for converting ethanol into acetaldehyde in the normal alcohol metabolism pathway?

  • Acetaldehyde dehydrogenase (ALDH)
  • H202/Catalase
  • Alcohol dehydrogenase (ADH) (correct)
  • CYP2E1 enzyme
  • What process leads to reversible steatosis (fat) in the liver with short-term ingestion of ethanol?

  • Acetaldehyde accumulation
  • Fatty acid oxidation
  • Fatty liver (correct)
  • Mitosis cell regeneration
  • Which of the following is a characteristic effect of alcohol metabolism in binge drinkers (>6 drinks)?

  • Decreased perfusion of hepatocytes
  • Activation of Acetyl-CoA synthesis pathway
  • Reduction in NAD+ levels
  • Production of ROS by CYP2E1 enzyme (correct)
  • Which condition usually requires daily ingestion of 80g or more of ethanol for 10-20 years to lead to severe hepatic injury?

    <p>Alcoholic Liver Disease</p> Signup and view all the answers

    What is the main reason for increased fat storage in the liver due to alcohol consumption?

    <p>NAD+ reduction</p> Signup and view all the answers

    Which protein aggregates are associated with Mallory-Denk bodies seen in alcoholic hepatitis?

    <p>Keratin protein aggregates</p> Signup and view all the answers

    What characteristic pattern does alcoholic steatofibrosis follow in the liver?

    <p>Central-portal fibrous septa</p> Signup and view all the answers

    "Laennec cirrhosis" is a term used specifically for cirrhosis due to which cause?

    <p>Alcoholic Liver Disease</p> Signup and view all the answers

    Which liver condition is characterized by fibrosis and conversion of the liver architecture into micro/macro nodules?

    <p>Alcoholic liver disease</p> Signup and view all the answers

    What is considered the gold standard for diagnosing liver diseases?

    <p>Liver biopsy</p> Signup and view all the answers

    What is the most common cause of chronic liver disease in the US?

    <p>Metabolic syndrome</p> Signup and view all the answers

    What is the main difference between Non-Alcoholic Fatty Liver Disease (NAFLD) and Alcoholic Liver Disease in terms of histological features?

    <p>Steatosis</p> Signup and view all the answers

    What causes the characteristic yellow, greasy appearance of liver lobes in individuals with NAFLD?

    <p>Widespread steatosis</p> Signup and view all the answers

    What initiates the degradation process of fat in hepatocytes leading to steatohepatitis?

    <p>Hydroxyl radical</p> Signup and view all the answers

    What histological feature differentiates NASH from alcoholic fatty liver disease?

    <p>Steatosis &gt;5% of hepatocytes</p> Signup and view all the answers

    'Neutrophilic infiltrate' is a characteristic feature associated with which type of liver disease?

    <p>Non-alcoholic steatohepatitis</p> Signup and view all the answers

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