Pathophysiology of Hepatitis, Steatosis, and Liver Abscess
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Questions and Answers

What is the unique feature of the RNA virus HDV?

  • Dependent on HEV for transmission
  • Dependent on HCV for replication
  • Dependent on HBV for its life cycle (correct)
  • Dependent on HAV for survival
  • What is the most common mode of transmission for HEV?

  • Enteric (water-borne) (correct)
  • Bloodborne
  • Respiratory droplets
  • Sexual contact
  • Which type of hepatitis has a high mortality rate among pregnant women?

  • Hepatitis A
  • Hepatitis C
  • Hepatitis B
  • Hepatitis E (correct)
  • What is the estimated number of individuals affected by HDV globally?

    <p>15 million individuals</p> Signup and view all the answers

    Which type of hepatitis is prevented by vaccination against another type of hepatitis?

    <p>Hepatitis B</p> Signup and view all the answers

    What is the most common cause of chronic viral hepatitis?

    <p>Hepatitis C Virus (HCV)</p> Signup and view all the answers

    Which disease is NOT mentioned as having morphological changes similar to acute and chronic viral hepatitis?

    <p>Alzheimer's disease</p> Signup and view all the answers

    Which virus is associated with a mild or subclinical acute infection in nearly two-thirds of adults?

    <p>Hepatitis B Virus (HBV)</p> Signup and view all the answers

    What is a common symptom of acute HBV infection?

    <p>Upper right quadrant pain</p> Signup and view all the answers

    In chronic HCV infection, what percentage of individuals develop cirrhosis over 20 to 30 years?

    <p>20%</p> Signup and view all the answers

    Which type of infection is known to have asymptomatic acute cases in about 85% of individuals?

    <p>Hepatitis C</p> Signup and view all the answers

    What is the risk faced by approximately 20% of HCV-infected individuals in terms of liver condition?

    <p>Cirrhosis development</p> Signup and view all the answers

    How can liver abscesses reach the liver?

    <p>Ascending infection via the gut and biliary tract</p> Signup and view all the answers

    Which condition is characterized by liver with mixed small and large fat droplets as well as ballooned hepatocytes?

    <p>Alcoholic hepatitis</p> Signup and view all the answers

    Which pathology exhibits portal enlargement without regenerative nodules and pipe-stem fibrosis?

    <p>Schistosomiasis</p> Signup and view all the answers

    What is one of the classic symptoms associated with liver abscesses?

    <p>Fever and right upper quadrant pain</p> Signup and view all the answers

    What is the characteristic morphology associated with schistosomiasis?

    <p>Presence of bumpy lesions with marked fibrosis</p> Signup and view all the answers

    In alcoholic hepatitis, what staining technique can be used to visualize the resemblance of liver features?

    <p>Masson trichrome stain</p> Signup and view all the answers

    What is a distinctive morphologic feature in chronic hepatitis B?

    <p>Ground glass hepatocytes</p> Signup and view all the answers

    Which form of alcoholic liver disease is characterized by dysfunction of mitochondria and cellular membranes?

    <p>Alcoholic steatohepatitis</p> Signup and view all the answers

    How can hepatitis B infection be confirmed morphologically?

    <p>Immunostaining for hepatitis B surface and core antigens</p> Signup and view all the answers

    What feature may be observed in chronic hepatitis C?

    <p>Focal bile duct injury</p> Signup and view all the answers

    What causes the cytoplasmic inclusions to appear light pink and finely granular in chronic hepatitis B?

    <p>Accumulation of hepatitis B surface antigen</p> Signup and view all the answers

    In alcoholic liver disease, what leads to varying degrees of inflammation and hepatocyte death?

    <p>Excessive alcohol intake</p> Signup and view all the answers

    What is the hallmark of alcohol-induced or nonalcoholic steatohepatitis?

    <p>Mallory hyaline formation</p> Signup and view all the answers

    Which term describes the clumping of intermediate filaments in hepatocytes?

    <p>Councilman bodies</p> Signup and view all the answers

    What type of necrosis involves the obliteration of the entire lobule in the liver?

    <p>Pan-acinar necrosis</p> Signup and view all the answers

    What is the primary cause of hepatocellular necrosis induced by acetaminophen overdose?

    <p>Confluent necrosis</p> Signup and view all the answers

    Which of the following is NOT commonly associated with viral hepatitis?

    <p>Bilirubin accumulation</p> Signup and view all the answers

    What is the term used to describe a focus of mononuclear infiltration surrounding an injured hepatocyte in chronic hepatitis?

    <p>Acidophil bodies</p> Signup and view all the answers

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