Acute Phase Reactant Proteins and Inflammation
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Questions and Answers

What is the purpose of immunoglobulins produced in response to foreign antigens?

  • To decrease inflammation
  • To increase synthesis of acute-phase reactant proteins
  • To transport thyroid hormones
  • To destroy foreign antigens (correct)

    • What is the normal reference range for total protein concentration in the blood?

  • 8.0-10.0 g/dL
  • 6.5-8.3 g/dL (correct)
  • 7.0-9.0 g/dL
  • 5.0-7.0 g/dL

    • What is the term for proteins that decrease in concentration during inflammation?

  • Inflammatory proteins
  • Humoral antibodies
  • Negative acute-phase proteins (correct)
  • Acute-phase proteins

    • What is prealbumin also termed as?

    <p>Transthyretin</p> Signup and view all the answers

    What is one of the causes of hypoproteinemia?

    <p>Gastrointestinal tract inflammation</p> Signup and view all the answers

    What is the normal reference range for albumin concentration in the blood?

    <p>3.5-5.0 g/dL</p> Signup and view all the answers

    What is prealbumin an indicator of?

    <p>Nutritional status</p> Signup and view all the answers

    What is one of the causes of hyperproteinemia?

    <p>Dehydration</p> Signup and view all the answers

    What is the primary function of albumin in the blood?

    <p>To transport various analytes throughout the body</p> Signup and view all the answers

    What is the primary location of albumin synthesis?

    <p>Liver</p> Signup and view all the answers

    What is α1-Acid glycoprotein and what is its function?

    <p>An acute-phase reactant that binds to basic drugs</p> Signup and view all the answers

    What is the result of decreased albumin levels in the blood?

    <p>Decreased plasma osmotic pressure</p> Signup and view all the answers

    What is the primary function of α1-antitrypsin?

    <p>To inhibit protease activity</p> Signup and view all the answers

    What is the commonality among conditions where ceruloplasmin is increased?

    <p>Pregnancy and inflammatory disorders</p> Signup and view all the answers

    What is the significance of elevated maternal serum AFP levels?

    <p>Indicates a high risk of neural tube defects</p> Signup and view all the answers

    What is the function of haptoglobin?

    <p>To bind free hemoglobin</p> Signup and view all the answers

    During which period of gestation does AFP level peak?

    <p>13-15 weeks</p> Signup and view all the answers

    What is the effect of nephrotic syndrome on haptoglobin levels?

    <p>Decreased</p> Signup and view all the answers

    What is the primary site of AFP synthesis during gestation?

    <p>Yolk sac</p> Signup and view all the answers

    What is the effect of nephrotic syndrome on α2-Macroglobulin levels?

    <p>Increased</p> Signup and view all the answers

    What binds to approximately 90% of serum copper?

    <p>Ceruloplasmin</p> Signup and view all the answers

    What is the normal adult level of AFP?

    <p>Very low</p> Signup and view all the answers

    What is decreased in Wilson disease?

    <p>Ceruloplasmin</p> Signup and view all the answers

    What is the effect of oral estrogen and oral contraceptives on ceruloplasmin levels?

    <p>Increased</p> Signup and view all the answers

    What is the function of α2-Macroglobulin?

    <p>To inhibit proteolytic enzymes</p> Signup and view all the answers

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