Acute Phase Reactant Proteins and Inflammation

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Questions and Answers

What is the purpose of immunoglobulins produced in response to foreign antigens?

  • To decrease inflammation
  • To increase synthesis of acute-phase reactant proteins
  • To transport thyroid hormones
  • To destroy foreign antigens (correct)

What is the normal reference range for total protein concentration in the blood?

  • 8.0-10.0 g/dL
  • 6.5-8.3 g/dL (correct)
  • 7.0-9.0 g/dL
  • 5.0-7.0 g/dL

What is the term for proteins that decrease in concentration during inflammation?

  • Inflammatory proteins
  • Humoral antibodies
  • Negative acute-phase proteins (correct)
  • Acute-phase proteins

What is prealbumin also termed as?

<p>Transthyretin (D)</p> Signup and view all the answers

What is one of the causes of hypoproteinemia?

<p>Gastrointestinal tract inflammation (B)</p> Signup and view all the answers

What is the normal reference range for albumin concentration in the blood?

<p>3.5-5.0 g/dL (D)</p> Signup and view all the answers

What is prealbumin an indicator of?

<p>Nutritional status (C)</p> Signup and view all the answers

What is one of the causes of hyperproteinemia?

<p>Dehydration (A)</p> Signup and view all the answers

What is the primary function of albumin in the blood?

<p>To transport various analytes throughout the body (B)</p> Signup and view all the answers

What is the primary location of albumin synthesis?

<p>Liver (D)</p> Signup and view all the answers

What is α1-Acid glycoprotein and what is its function?

<p>An acute-phase reactant that binds to basic drugs (C)</p> Signup and view all the answers

What is the result of decreased albumin levels in the blood?

<p>Decreased plasma osmotic pressure (C)</p> Signup and view all the answers

What is the primary function of α1-antitrypsin?

<p>To inhibit protease activity (C)</p> Signup and view all the answers

What is the commonality among conditions where ceruloplasmin is increased?

<p>Pregnancy and inflammatory disorders (D)</p> Signup and view all the answers

What is the significance of elevated maternal serum AFP levels?

<p>Indicates a high risk of neural tube defects (A)</p> Signup and view all the answers

What is the function of haptoglobin?

<p>To bind free hemoglobin (D)</p> Signup and view all the answers

During which period of gestation does AFP level peak?

<p>13-15 weeks (C)</p> Signup and view all the answers

What is the effect of nephrotic syndrome on haptoglobin levels?

<p>Decreased (C)</p> Signup and view all the answers

What is the primary site of AFP synthesis during gestation?

<p>Yolk sac (B)</p> Signup and view all the answers

What is the effect of nephrotic syndrome on α2-Macroglobulin levels?

<p>Increased (A)</p> Signup and view all the answers

What binds to approximately 90% of serum copper?

<p>Ceruloplasmin (B)</p> Signup and view all the answers

What is the normal adult level of AFP?

<p>Very low (B)</p> Signup and view all the answers

What is decreased in Wilson disease?

<p>Ceruloplasmin (D)</p> Signup and view all the answers

What is the effect of oral estrogen and oral contraceptives on ceruloplasmin levels?

<p>Increased (C)</p> Signup and view all the answers

What is the function of α2-Macroglobulin?

<p>To inhibit proteolytic enzymes (C)</p> Signup and view all the answers

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