Acute Phase Reactant Proteins and Inflammation

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What is the purpose of immunoglobulins produced in response to foreign antigens?

To decrease inflammation
To increase synthesis of acute-phase reactant proteins
To transport thyroid hormones
To destroy foreign antigens (correct)

What is the normal reference range for total protein concentration in the blood?

8.0-10.0 g/dL
6.5-8.3 g/dL (correct)
7.0-9.0 g/dL
5.0-7.0 g/dL

What is the term for proteins that decrease in concentration during inflammation?

Inflammatory proteins
Humoral antibodies
Negative acute-phase proteins (correct)
Acute-phase proteins

What is prealbumin also termed as?

Transthyretin (D) Signup and view all the answers

What is one of the causes of hypoproteinemia?

Gastrointestinal tract inflammation (B) Signup and view all the answers

What is the normal reference range for albumin concentration in the blood?

3.5-5.0 g/dL (D) Signup and view all the answers

What is prealbumin an indicator of?

Nutritional status (C) Signup and view all the answers

What is one of the causes of hyperproteinemia?

Dehydration (A) Signup and view all the answers

What is the primary function of albumin in the blood?

To transport various analytes throughout the body (B) Signup and view all the answers

What is the primary location of albumin synthesis?

Liver (D) Signup and view all the answers

What is α1-Acid glycoprotein and what is its function?

An acute-phase reactant that binds to basic drugs (C) Signup and view all the answers

What is the result of decreased albumin levels in the blood?

Decreased plasma osmotic pressure (C) Signup and view all the answers

What is the primary function of α1-antitrypsin?

To inhibit protease activity (C) Signup and view all the answers

What is the commonality among conditions where ceruloplasmin is increased?

Pregnancy and inflammatory disorders (D) Signup and view all the answers

What is the significance of elevated maternal serum AFP levels?

Indicates a high risk of neural tube defects (A) Signup and view all the answers

What is the function of haptoglobin?

To bind free hemoglobin (D) Signup and view all the answers

During which period of gestation does AFP level peak?

13-15 weeks (C) Signup and view all the answers

What is the effect of nephrotic syndrome on haptoglobin levels?

Decreased (C) Signup and view all the answers

What is the primary site of AFP synthesis during gestation?

Yolk sac (B) Signup and view all the answers

What is the effect of nephrotic syndrome on α2-Macroglobulin levels?

Increased (A) Signup and view all the answers

What binds to approximately 90% of serum copper?

Ceruloplasmin (B) Signup and view all the answers

What is the normal adult level of AFP?

Very low (B) Signup and view all the answers

What is decreased in Wilson disease?

Ceruloplasmin (D) Signup and view all the answers

What is the effect of oral estrogen and oral contraceptives on ceruloplasmin levels?

Increased (C) Signup and view all the answers

What is the function of α2-Macroglobulin?

To inhibit proteolytic enzymes (C) Signup and view all the answers