Acute Myeloid Leukemia (AML) Diagnosis

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18 Questions

Auer rods are characteristic of the M3 ______ type of acute leukemia.

round

In the French-American-British (FAB) classification, the ______ of blasts in the bone marrow is used to diagnose acute leukemia.

percentage

Type 1 blasts are characterized by the absence of ______ granules and a high nucleus-to-cytoplasm ratio.

cytoplasmic

In the FAB classification, the morphology of ______ cells is used to subgroup acute leukemias.

proliferating

The World Health Organization (WHO) requires a finding of at least ______ % blast in the BM for the diagnosis of majority of acute leukemias.

20

M5 blasts are characterized by a ______ nucleus-to-cytoplasm ratio and the presence of few azurophilic granules.

decreased

Acute Myeloid Leukemia is a progressive malignant disease of ______ tissue.

hematopoietic

M7 blasts are characterized by a ______ shape and abundant cytoplasm.

megakaryoblastic

Radiation, including ______ and gamma rays, is a risk factor for Acute Myeloid Leukemia.

UV

The morphological classification of Acute Myeloid Leukemia includes M1, M2, and M3, which describe the ______ of the cells.

maturation

The diagnosis of Acute Myeloid Leukemia requires testing to detect the presence or absence of ______ anomalies.

genetic

Cytogenetic tests are run to detect ______ aberrations, such as aneuploidy and breakage, in Acute Myeloid Leukemia.

chromosomal

In M0: Acute Myeloblastic Leukemia with Minimal Differentiation, blast cells are ______+.

CD13+, CD33+, CD34+, CD117+

In Acute Myeloblastic Leukemia, Auer rods are ______.

absent

In M4e, there is an associated deletion or inversion of the long arm of ______.

chromosome 16

M5: Acute Monocytic Leukemia is characterized by ______ of organ involvement.

Highest incidence

In M5a, more than ______% of the monocytic compartment are blasts.

80

In M5b, there is a presence of all stages of ______ development.

monocytic

Learn about the diagnosis and classification of Acute Myeloid Leukemia (AML), a progressive malignant disease of the hematopoietic stem cells. Understand the role of blast cells in the bone marrow and the importance of cytogenetic tests in detecting genetic anomalies.

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