Acute Myeloid Leukemia (AML) Diagnosis

Deletion or inversion of the long arm of chromosome 16

Large blast cells with lacy, delicate chromatin

CD13+, CD33+, CD34+, and CD117+

<p>Highest incidence of organ involvement and extramedullary tissue masses, including CNS involvement</p> Signup and view all the answers

<p>Absence of Auer rods and no clear evidence of cellular maturation</p> Signup and view all the answers

<p>Positive with PAS and chloroacetate esterase</p> Signup and view all the answers

<p>Finding of at least 20% blast in the bone marrow (BM)</p> Signup and view all the answers

<p>Chromosomal aberrations (aneuploidy and breakage)</p> Signup and view all the answers

<p>Round to oval, with scant, variably granulated cytoplasm</p> Signup and view all the answers

<p>Presence of maturation in M2, and prominent azurophilic granules and/or Auer rods in M3</p> Signup and view all the answers

<p>Radiation exposure, specifically UV and gamma rays</p> Signup and view all the answers

<p>Progressive malignant disease of hematopoietic tissue, with a predominance of immature marrow cells</p> Signup and view all the answers

<p>&gt;30%</p> Signup and view all the answers

<p>No evidence of cytoplasmic differentiation and absence of cytoplasmic granules</p> Signup and view all the answers

<p>Type 2 blasts show some evidence of differentiation and have a few azurophilic granules</p> Signup and view all the answers

<p>Round to single, variable, monoblast, indented, folded, or lacy</p> Signup and view all the answers

<p>M6 blasts are erythroblastic, while M7 blasts are megakaryoblastic</p> Signup and view all the answers

<p>To provide a uniform method of subgrouping the different acute leukemias based on a standardized system of nomenclature and morphologic criteria</p> Signup and view all the answers