Acute Myeloid Leukemia (AML) Diagnosis

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What is the characteristic cytogenetic abnormality associated with M4e subtype of Acute Myeloid Leukemia?

Deletion or inversion of the long arm of chromosome 16

What is the characteristic morphological feature of blast cells in M5a subtype of Acute Monocytic Leukemia?

Large blast cells with lacy, delicate chromatin

What immunophenotypic features are characteristic of blast cells in Acute Myeloblastic Leukemia with Minimal Differentiation?

CD13+, CD33+, CD34+, and CD117+

What is the characteristic clinical presentation of M5 subtype of Acute Monocytic Leukemia?

Highest incidence of organ involvement and extramedullary tissue masses, including CNS involvement Signup and view all the answers

What is the characteristic morphological feature of M0 subtype of Acute Myeloid Leukemia?

Absence of Auer rods and no clear evidence of cellular maturation Signup and view all the answers

What is the characteristic enzymatic feature of M5 subtype of Acute Monocytic Leukemia?

Positive with PAS and chloroacetate esterase Signup and view all the answers

What is the primary requirement for the diagnosis of acute leukemias, according to the World Health Organization (WHO)?

Finding of at least 20% blast in the bone marrow (BM) Signup and view all the answers

What type of genetic anomalies can be detected through cytogenetic tests in Acute Myeloid Leukemia (AML) diagnosis?

Chromosomal aberrations (aneuploidy and breakage) Signup and view all the answers

What is the characteristic morphology of M1 AML blast cells?

Round to oval, with scant, variably granulated cytoplasm Signup and view all the answers

What is the primary distinction between M2 and M3 AML classifications?

Presence of maturation in M2, and prominent azurophilic granules and/or Auer rods in M3 Signup and view all the answers

What is a common etiological factor in the development of Acute Myeloid Leukemia?

Radiation exposure, specifically UV and gamma rays Signup and view all the answers

What is the characteristic clinical presentation of Acute Myeloid Leukemia?

Progressive malignant disease of hematopoietic tissue, with a predominance of immature marrow cells Signup and view all the answers

What is the minimum percentage of blasts in the bone marrow required for a diagnosis of acute leukemia according to the French-American-British (FAB) classification?

>30% Signup and view all the answers

What is the characteristic feature of Type 1 blasts in the FAB classification?

No evidence of cytoplasmic differentiation and absence of cytoplasmic granules Signup and view all the answers

How do Type 2 blasts differ from Type 1 blasts in the FAB classification?

Type 2 blasts show some evidence of differentiation and have a few azurophilic granules Signup and view all the answers

What is the characteristic morphology of M5 blasts in the FAB classification?

Round to single, variable, monoblast, indented, folded, or lacy Signup and view all the answers

What is the primary difference between M6 and M7 blasts in the FAB classification?

M6 blasts are erythroblastic, while M7 blasts are megakaryoblastic Signup and view all the answers

What is the purpose of the French-American-British (FAB) classification system?

To provide a uniform method of subgrouping the different acute leukemias based on a standardized system of nomenclature and morphologic criteria Signup and view all the answers