Podcast
Questions and Answers
What is the characteristic chromosomal abnormality associated with chronic myeloid leukemia (CML)?
What is the characteristic chromosomal abnormality associated with chronic myeloid leukemia (CML)?
- t(9; 22) (q11; q34) translocation (correct)
- t(22; 11) (q9; q34) translocation
- t(22; 9) (q34; q11) translocation
- t(11; 22) (q34; q9) translocation
Which symptoms are commonly associated with chronic myeloid leukemia?
Which symptoms are commonly associated with chronic myeloid leukemia?
- Tachycardia, pallor, and decreased leukocyte count
- Weight loss, anorexia, and splenomegaly (correct)
- Visual disturbances, hypotension, and hyperuricemia
- Weight gain, euphoria, and decreased platelet count
What is the male to female ratio in chronic myeloid leukemia?
What is the male to female ratio in chronic myeloid leukemia?
- 3 : 1
- 2 : 1
- 1 : 2
- 1.4 : 1 (correct)
What is the most frequently affected age group in chronic myeloid leukemia?
What is the most frequently affected age group in chronic myeloid leukemia?
Which laboratory finding is characteristic of chronic myeloid leukemia?
Which laboratory finding is characteristic of chronic myeloid leukemia?
What is the gene fusion associated with chronic myeloid leukemia?
What is the gene fusion associated with chronic myeloid leukemia?
What type of stem cells are affected in chronic myeloid leukemia?
What type of stem cells are affected in chronic myeloid leukemia?
Which translocation results in the Ph chromosome in chronic myeloid leukemia?
Which translocation results in the Ph chromosome in chronic myeloid leukemia?
In what percentage of cases is the BCR - ABL1 gene fusion present in chronic myeloid leukemia?
In what percentage of cases is the BCR - ABL1 gene fusion present in chronic myeloid leukemia?
What is the most common form of acute leukemia in adults?
What is the most common form of acute leukemia in adults?
At what age does acute myeloid leukemia become increasingly common?
At what age does acute myeloid leukemia become increasingly common?
What is the typical presentation of anemia in acute myeloid leukemia?
What is the typical presentation of anemia in acute myeloid leukemia?
What is typically observed in the blood film examination of acute myeloid leukemia?
What is typically observed in the blood film examination of acute myeloid leukemia?
What is the typical characteristic of blast cells in acute myeloid leukemia?
What is the typical characteristic of blast cells in acute myeloid leukemia?
Which tests are often positive in patients with the promyelocytic variant of AML?
Which tests are often positive in patients with the promyelocytic variant of AML?
What are used to classify the majority of cases of AML?
What are used to classify the majority of cases of AML?
How are chronic leukemias distinguished from acute leukemias?
How are chronic leukemias distinguished from acute leukemias?
Which genes are commonly affected by cytogenetic abnormalities in AML?
Which genes are commonly affected by cytogenetic abnormalities in AML?
What is typically revealed by biochemical tests in AML before treatment begins?
What is typically revealed by biochemical tests in AML before treatment begins?
What is the defining characteristic of macrocytic anemia?
What is the defining characteristic of macrocytic anemia?
Which vitamin deficiency can cause defective DNA synthesis and lead to megaloblastic anemia?
Which vitamin deficiency can cause defective DNA synthesis and lead to megaloblastic anemia?
How is vitamin B12 acquired by animals?
How is vitamin B12 acquired by animals?
What is the glycoprotein that combines with vitamin B12 to facilitate its absorption?
What is the glycoprotein that combines with vitamin B12 to facilitate its absorption?
Which type of food does not naturally contain vitamin B12?
Which type of food does not naturally contain vitamin B12?
What is the main effect of a deficiency in folate or vitamin B12 on red blood cells?
What is the main effect of a deficiency in folate or vitamin B12 on red blood cells?
What is the specific surface receptor for IF that can bind to the IF-B12 complex?
What is the specific surface receptor for IF that can bind to the IF-B12 complex?
What protein directs the endocytosis of the cubilin IF-B12 complex in the distal ileum?
What protein directs the endocytosis of the cubilin IF-B12 complex in the distal ileum?
Which plasma-binding protein delivers B12 to bone marrow and other tissues?
Which plasma-binding protein delivers B12 to bone marrow and other tissues?
What is the coenzyme for methionine synthase, responsible for methylation of homocysteine to methionine?
What is the coenzyme for methionine synthase, responsible for methylation of homocysteine to methionine?
What is thought to cause megaloblastic anemia by inhibiting thymidylate synthesis?
What is thought to cause megaloblastic anemia by inhibiting thymidylate synthesis?
Which deficiency can cause a progressive neuropathy affecting the peripheral sensory nerves and posterior and lateral columns?
Which deficiency can cause a progressive neuropathy affecting the peripheral sensory nerves and posterior and lateral columns?
What does deficiency in the mother predispose to in the fetus?
What does deficiency in the mother predispose to in the fetus?
What is typically used for the treatment of B12 deficiency?
What is typically used for the treatment of B12 deficiency?
How are dietary folates converted once inside the cell?
How are dietary folates converted once inside the cell?
What results from increased ineffective erythropoiesis in the bone marrow?
What results from increased ineffective erythropoiesis in the bone marrow?
Flashcards are hidden until you start studying
