Podcast
Questions and Answers
What is a characteristic feature of myeloproliferative neoplasms?
What is a characteristic feature of myeloproliferative neoplasms?
- The neoplastic clone continues to undergo terminal differentiation but exhibits increased or dysregulated growth. (correct)
- The neoplastic clone is characterized by a decrease in formed elements in the peripheral blood.
- The neoplastic clone fails to undergo terminal differentiation.
- The neoplastic clone is characterized by a complete block in differentiation.
What is the diagnostic criterion for Acute Myeloid Leukemia (AML)?
What is the diagnostic criterion for Acute Myeloid Leukemia (AML)?
- Neoplastic accumulation of immature myeloid cells (> 10%) in the bone marrow
- Neoplastic accumulation of immature myeloid cells (> 20%) in the bone marrow (correct)
- Neoplastic accumulation of immature lymphoid cells (> 20%) in the bone marrow
- Neoplastic accumulation of immature myeloid cells (> 30%) in the bone marrow
What is characteristic of Auer rods in AML?
What is characteristic of Auer rods in AML?
- They are crystalline aggregates of myeloperoxidase (MPO) (correct)
- They are present in the nucleus of myeloblasts
- They are amorphous aggregations of myeloperoxidase (MPO)
- They are membranous structures in the cytoplasm of myeloblasts
What is the characteristic translocation in Acute Promyelocytic Leukemia (APL)?
What is the characteristic translocation in Acute Promyelocytic Leukemia (APL)?
What is the treatment for Acute Promyelocytic Leukemia (APL)?
What is the treatment for Acute Promyelocytic Leukemia (APL)?
What is characteristic of Acute Monocytic Leukemia?
What is characteristic of Acute Monocytic Leukemia?
What is the characteristic feature of the peripheral blood smear in CML?
What is the characteristic feature of the peripheral blood smear in CML?
What is the distinguishing feature of CML compared to a leukemoid reaction?
What is the distinguishing feature of CML compared to a leukemoid reaction?
What is the common cytogenetic abnormality seen in CML?
What is the common cytogenetic abnormality seen in CML?
What is the underlying mechanism of marrow fibrosis in myelofibrosis?
What is the underlying mechanism of marrow fibrosis in myelofibrosis?
What is the characteristic feature of the peripheral blood smear in myelofibrosis?
What is the characteristic feature of the peripheral blood smear in myelofibrosis?
What is the associated mutation seen in half of the cases of myelofibrosis?
What is the associated mutation seen in half of the cases of myelofibrosis?
What is the characteristic age of onset for Acute megakaryoblastic leukemia associated with Down syndrome?
What is the characteristic age of onset for Acute megakaryoblastic leukemia associated with Down syndrome?
What is the primary complication of Myelodysplastic syndromes?
What is the primary complication of Myelodysplastic syndromes?
What is the characteristic feature of Myeloproliferative Neoplasms?
What is the characteristic feature of Myeloproliferative Neoplasms?
What is the genetic abnormality driving Chronic Myeloid Leukemia (CML)?
What is the genetic abnormality driving Chronic Myeloid Leukemia (CML)?
What is the first line treatment for Chronic Myeloid Leukemia (CML)?
What is the first line treatment for Chronic Myeloid Leukemia (CML)?
What is a common physical finding in patients with Chronic Myeloid Leukemia (CML)?
What is a common physical finding in patients with Chronic Myeloid Leukemia (CML)?
