Acute Leukemias
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Questions and Answers

Which of the following is NOT a symptom of acute leukemias?

  • Headache (correct)
  • Bone pain
  • Fatigue
  • Weight loss

What is the goal of treatment for acute myeloid leukemia (AML)?

  • Induce remission (correct)
  • Promote clonal expansion
  • Maintain remission
  • Prevent relapse

Which form of leukemia is considered a medical emergency?

  • Acute Promyelocytic Leukemia (APML)
  • Chronic Myeloid Leukemia (CML)
  • Acute Lymphoblastic Leukemia (ALL)
  • Acute Myeloid Leukemia (AML) (correct)

Which factor is NOT considered in the NCCN Guidelines for treatment selection in Acute Myeloid Leukemia?

<p>Comorbidities (B)</p> Signup and view all the answers

What is the recommended dose of Midostaurin (RYDAPT) for remission induction in AML?

<p>50 mg by mouth BID on days 8 to 21 (A)</p> Signup and view all the answers

What is the mechanism of action of Gemtuzumab Ozogamicin (Mylotarg)?

<p>Binds to the CD33 antigen (B)</p> Signup and view all the answers

What is the recommended consolidation therapy for treatment-related AML?

<p>Liposomal cytarabine + daunorubicin (C)</p> Signup and view all the answers

Which of the following symptoms is NOT commonly associated with acute leukemias?

<p>Headache (D)</p> Signup and view all the answers

What is the 5-year survival rate for acute myeloid leukemia (AML) according to the NCCN Guidelines?

<p>5-14% (A)</p> Signup and view all the answers

Which of the following is NOT a goal of treatment for acute myeloid leukemia (AML)?

<p>Eradicate all leukemic cells (C)</p> Signup and view all the answers

Which factor is NOT considered in the NCCN Guidelines for treatment selection in Acute Myeloid Leukemia?

<p>Extramedullary disease or CNS involvement (B)</p> Signup and view all the answers

What is the recommended consolidation therapy for treatment-related AML?

<p>Liposomal cytarabine + daunorubicin (Vyxeos) (B)</p> Signup and view all the answers

What is the mechanism of action of Gemtuzumab Ozogamicin (Mylotarg)?

<p>Binds to the CD33 antigen, induces cell cycle arrest and apoptosis (A)</p> Signup and view all the answers

What are some options for Consolidation Therapy in patients, according to the NCCN Guidelines?

<p>Cyclophosphamide, doxorubicin, etoposide (B)</p> Signup and view all the answers

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