Acute Leukemias
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Questions and Answers

Which of the following is NOT a symptom of acute leukemias?

  • Headache (correct)
  • Bone pain
  • Fatigue
  • Weight loss

    • What is the goal of treatment for acute myeloid leukemia (AML)?

  • Induce remission (correct)
  • Promote clonal expansion
  • Maintain remission
  • Prevent relapse

    • Which form of leukemia is considered a medical emergency?

  • Acute Promyelocytic Leukemia (APML)
  • Chronic Myeloid Leukemia (CML)
  • Acute Lymphoblastic Leukemia (ALL)
  • Acute Myeloid Leukemia (AML) (correct)

    • Which factor is NOT considered in the NCCN Guidelines for treatment selection in Acute Myeloid Leukemia?

    <p>Comorbidities</p> Signup and view all the answers

    What is the recommended dose of Midostaurin (RYDAPT) for remission induction in AML?

    <p>50 mg by mouth BID on days 8 to 21</p> Signup and view all the answers

    What is the mechanism of action of Gemtuzumab Ozogamicin (Mylotarg)?

    <p>Binds to the CD33 antigen</p> Signup and view all the answers

    What is the recommended consolidation therapy for treatment-related AML?

    <p>Liposomal cytarabine + daunorubicin</p> Signup and view all the answers

    Which of the following symptoms is NOT commonly associated with acute leukemias?

    <p>Headache</p> Signup and view all the answers

    What is the 5-year survival rate for acute myeloid leukemia (AML) according to the NCCN Guidelines?

    <p>5-14%</p> Signup and view all the answers

    Which of the following is NOT a goal of treatment for acute myeloid leukemia (AML)?

    <p>Eradicate all leukemic cells</p> Signup and view all the answers

    Which factor is NOT considered in the NCCN Guidelines for treatment selection in Acute Myeloid Leukemia?

    <p>Extramedullary disease or CNS involvement</p> Signup and view all the answers

    What is the recommended consolidation therapy for treatment-related AML?

    <p>Liposomal cytarabine + daunorubicin (Vyxeos)</p> Signup and view all the answers

    What is the mechanism of action of Gemtuzumab Ozogamicin (Mylotarg)?

    <p>Binds to the CD33 antigen, induces cell cycle arrest and apoptosis</p> Signup and view all the answers

    What are some options for Consolidation Therapy in patients, according to the NCCN Guidelines?

    <p>Cyclophosphamide, doxorubicin, etoposide</p> Signup and view all the answers

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