Acute Inflammation Overview

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Questions and Answers

The acute inflammatory response rapidly delivers leukocytes and plasma proteins to sites of injury?

True (A)

What is the primary function of leukocytes in the acute inflammatory response?

Leukocytes clear the invaders and begin the process of digesting necrotic tissues.

What are the two major components of acute inflammation?

  • Immune responses and tissue repair
  • Blood clotting and wound healing
  • Vascular changes and cellular events (correct)
  • Inflammatory mediators and pain receptors

Which of the following is NOT a vascular change associated with acute inflammation?

<p>Decreased blood flow (C)</p> Signup and view all the answers

What is the primary function of increased vascular permeability during acute inflammation?

<p>Increased vascular permeability allows plasma proteins to leave the circulation.</p> Signup and view all the answers

Which of the following is a cellular event associated with acute inflammation?

<p>Activation of leukocytes to eliminate the offending agent (D)</p> Signup and view all the answers

Neutrophils are the primary leukocytes involved in acute inflammation.

<p>True (A)</p> Signup and view all the answers

What are the three major local manifestations of acute inflammation, compared to normal tissue?

<p>Vascular dilation and increased blood flow, extravasation of plasma fluid and proteins, and leukocyte emigration and accumulation.</p> Signup and view all the answers

What is another term for the extravasation of plasma fluid and proteins during inflammation?

<p>Edema (D)</p> Signup and view all the answers

Which of the following is NOT a common cause of acute inflammation?

<p>Tissue repair (D)</p> Signup and view all the answers

What is the term for immune reactions against environmental substances or self-tissues?

<p>Hypersensitivity (B)</p> Signup and view all the answers

What are two possible outcomes of acute inflammation?

<p>Resolution and chronic inflammation (D)</p> Signup and view all the answers

Under what conditions does acute inflammation likely resolve?

<p>When the injury is limited or short-lived, minimal tissue damage has occurred, and the injured tissue is capable of regenerating.</p> Signup and view all the answers

Chronic inflammation always leads to scarring.

<p>False (B)</p> Signup and view all the answers

What is the outcome of acute inflammation that progresses to chronic inflammation?

<p>Fibrosis (B)</p> Signup and view all the answers

What is the term for the formation of pus during chronic inflammation?

<p>Abscess (C)</p> Signup and view all the answers

Chronic inflammation involves mainly neutrophils.

<p>False (B)</p> Signup and view all the answers

Flashcards

Acute inflammation

A rapid response of the body to injury, involving the delivery of leukocytes and plasma proteins to the site of injury.

Vasodilation in acute inflammation

The process where blood vessels widen, allowing more blood to flow to the injured area.

Increased Vascular Permeability in acute inflammation

The process where blood vessels become more permeable, allowing fluid and proteins to leak out into the surrounding tissues.

Cellular recruitment in acute inflammation

The movement of leukocytes (immune cells) from the bloodstream into the injured tissue.

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Leukocyte activation in acute inflammation

The process where leukocytes are activated to fight off the invading pathogens or remove the damaged cells.

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Neutrophils in acute inflammation

The primary type of leukocyte involved in the early stages of acute inflammation.

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Infections as a cause of acute inflammation

The primary cause of acute inflammation, leading to activation of the immune system.

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Trauma as a cause of acute inflammation

Any physical injury, whether blunt or penetrating, can trigger an acute inflammatory response.

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Physical agents as a cause of acute inflammation

Exposure to extreme heat, cold, or radiation can cause damage and trigger acute inflammation.

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Chemical agents as a cause of acute inflammation

Chemicals can irritate tissues and trigger acute inflammation.

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Tissue necrosis as a cause of acute inflammation

When cells die due to injury, they trigger an inflammatory response to remove the dead tissue.

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Foreign bodies as a cause of acute inflammation

Foreign objects such as splinters, dirt, or sutures can trigger an inflammatory response.

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Immune reactions as a cause of acute inflammation

Immune reactions to harmless substances or even the body's own tissues can trigger inflammation.

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Resolution of acute inflammation

The most desirable outcome of acute inflammation, where the injured tissue fully recovers.

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Conditions for resolution of acute inflammation

Conditions required for successful resolution of acute inflammation.

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Chronic inflammation

A state of prolonged inflammation that can lead to tissue damage and scarring.

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Outcomes of chronic inflammation

The possible outcomes of chronic inflammation.

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Regeneration in acute inflammation

The process where the injured tissue is replaced with new, healthy tissue, restoring function.

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Repair in acute inflammation

The process where the injured tissue is replaced with scar tissue, which can impair function.

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Study Notes

Acute Inflammation

  • Rapidly delivers leukocytes and plasma proteins to injury sites.
  • Leukocytes clear invaders and digest necrotic tissues.

Components of Acute Inflammation

  • Vascular Changes:
    • Vasodilation leads to increased blood flow.
    • Increased vascular permeability allows plasma proteins to exit the circulation.
  • Cellular Events:
    • Leukocyte recruitment and emigration to injury sites.
    • Leukocyte activation to eliminate the offending agent.
    • Neutrophils are the primary leukocytes in acute inflammation.

Causes of Acute Inflammation

  • Infections
  • Trauma (blunt and penetrating)
  • Physical agents
  • Chemical agents
  • Tissue necrosis
  • Foreign bodies (splinters, dirt, sutures, crystal deposits)
  • Immune reactions (hypersensitivity reactions) against environmental substances or "self" tissues.

Outcomes of Acute Inflammation

  • Resolution: Regeneration and repair.
    • Limited or short-lived injury.
    • Minimal tissue damage.
    • Injured tissue capable of regeneration.
  • Chronic Inflammation:
    • Restoration of normal structure and function.
    • May lead to scarring.

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