Acute Inflammation PDF
Document Details
Uploaded by GainfulGray
Assafa Medical College
Tags
Summary
This document provides an overview of acute inflammation, covering vascular changes, cellular events, causes, and outcomes. It details the process of acute inflammation, from initial injury to resolution or chronic inflammation.
Full Transcript
ACUTE INFLAMMATION The acute inflammatory response rapidly delivers leukocytes and plasma proteins to sites of injury. leukocytes clear the invaders and begin the process of digesting and getting rid of necrotic tissues. Acute inflammation has two major components...
ACUTE INFLAMMATION The acute inflammatory response rapidly delivers leukocytes and plasma proteins to sites of injury. leukocytes clear the invaders and begin the process of digesting and getting rid of necrotic tissues. Acute inflammation has two major components Vascular changes: 1. Vasodilation: results in increased blood flow 2. increased vascular permeability: permit plasma proteins to leave the circulation Cellular events: 1. cellular recruitment :emigration of the leukocytes from the circulation and accumulation in the focus of injury 2. activation of the leukocytes, enabling them to eliminate the offending agent The principal leukocytes in acute inflammation are neutrophils causes of Acute Inflmmation 1. Infections 2. Trauma (blunt and penetrating). 3. Physical agents 4. chemical agents 5. Tissue necrosis. 6. Foreign bodies (splinters, dirt, sutures, crystal deposits) 7. Immune reactions (also called hypersensitivity reactions) against environmental substances or against “self” tissues. Outcomes of Acute Inflmmation 1. Resolution: Regeneration and repair. Conditions: 1. injury is limited or short-lived, 2. minimal tissue damage, a 3. injured tissue is capable of regenerating, 2. Chronic inflmmation : chronic inflammation may be followed by restoration of normal structure and function or may lead to scarring.
