Acute Inflammation and Major Components
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Questions and Answers

What is the main focus of Alitalo's review?

  • The regulation of vascular permeability
  • The functions of Toll-like receptors
  • The cell biology of lymphatic vessels (correct)
  • The role of endothelial junctions in leukocyte extravasation
  • Which topic does Vestweber primarily discuss in the review?

  • Regulation of interendothelial junctions (correct)
  • Vascular permeability and leukocyte extravasation
  • Overview of inflammation
  • Pattern recognition receptors
  • What is the main subject of the review by Takeuchi and Akira?

  • Vascular permeability
  • Inflammatory and neoplastic diseases
  • Endothelial junctions
  • Pattern recognition receptors (correct)
  • Who provides an overview of inflammation among the listed authors?

    <p>Hedwig S. Murphy</p> Signup and view all the answers

    Which review covers the roles of Toll-like receptors in host defense?

    <p>Takeuchi</p> Signup and view all the answers

    In which publication is the regulation of interendothelial junctions discussed?

    <p>Vestweber</p> Signup and view all the answers

    Which review emphasizes the functions of lymphatic vessels in diseases?

    <p>Alitalo</p> Signup and view all the answers

    What is the main purpose of acute inflammation?

    <p>To protect and aid in wound healing</p> Signup and view all the answers

    Which group of cells are involved in the major cellular and tissue participants in inflammation?

    <p>Neutrophils, monocytes, eosinophils, lymphocytes, basophils, and platelets</p> Signup and view all the answers

    How are inflammatory conditions usually described?

    <p>-Itis</p> Signup and view all the answers

    What are the sets of chemicals that mediate the processes of inflammation called?

    <p>Chemical mediators of inflammation</p> Signup and view all the answers

    Which of the following is NOT a common chronic disease mentioned in the text associated with inflammation?

    <p>Osteoporosis</p> Signup and view all the answers

    What type of conditions can inflammation lead to?

    <p>Ranging from local tissue damage to serious diseases like auto-immune diseases and cancer</p> Signup and view all the answers

    What type of cells are responsible for delivering cells and molecules of host defense from the circulation to the sites of injury?

    <p><em>A combination</em> of neutrophils, monocytes, eosinophils, lymphocytes, basophils, and platelets</p> Signup and view all the answers

    What is one of the major components of acute inflammation according to the text?

    <p>Dilation of small vessels</p> Signup and view all the answers

    Which cells are primarily involved in the emigration component of acute inflammation?

    <p>Neutrophils</p> Signup and view all the answers

    What causes the heat and redness (erythema) in an area of acute inflammation?

    <p>Vasodilation of arterioles</p> Signup and view all the answers

    What is the main effect of increased permeability of microvasculature in acute inflammation?

    <p>Exudation into extravascular tissues</p> Signup and view all the answers

    What type of cells rest along the endothelium during acute inflammation?

    <p>Neutrophils</p> Signup and view all the answers

    What triggers inflammation by releasing molecules according to the text?

    <p>Injured/necrotic cells</p> Signup and view all the answers

    Which foreign bodies may elicit inflammation either by themselves or due to carrying microbes?

    <p>Dust particles</p> Signup and view all the answers

    What are the 3 types of selectins mentioned in the text?

    <p>L-selectin, E-selectin, P-selectin</p> Signup and view all the answers

    What type of ligands bind to selectins?

    <p>Sialylated oligosaccharides bound to mucin-like glycoproteins</p> Signup and view all the answers

    Which cytokines are mentioned to act on the ligands for selectins during inflammation?

    <p>TNF and IL-1</p> Signup and view all the answers

    Which of the following adhesion molecules is induced by cytokines in post-capillary venules?

    <p>E-selectin</p> Signup and view all the answers

    Which type of proteins mediate firm adhesion of white blood cells to the endothelium?

    <p>Integrins</p> Signup and view all the answers

    What is the main ligand for β2 integrins on white blood cells?

    <p>ICAM-1</p> Signup and view all the answers

    Which integrins are converted to a high-affinity state upon activation by chemokines?

    <p>(LFA-1)</p> Signup and view all the answers

    What is the role of selectins in mediating leukocyte interactions?

    <p>Mediate initial rolling interactions of leukocytes</p> Signup and view all the answers

    Which cytokines induce the expression of adhesion molecules such as E-selectin and ligands for L-selectin on endothelial cells?

    <p>IL-1, TNF, &amp; cytokines</p> Signup and view all the answers

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