Actinic Keratosis Overview and Management

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Questions and Answers

What is mentioned as a funding source for the present manuscript?

  • European Research Council
  • National Institutes of Health
  • Health Foundation Limburg (correct)
  • World Health Organization

Which of the following institutions is listed as receiving grants?

  • Stanford University
  • Amgen (correct)
  • Johns Hopkins University
  • Harvard University

Which of the following is NOT mentioned as a contributor to the manuscript's funding?

  • Pfizer (correct)
  • Celgene
  • AbbVie
  • BMS

What type of support is indicated in the content provided?

<p>Financial grants from pharmaceutical companies (A)</p> Signup and view all the answers

Which of these institutions is listed as providing a grant?

<p>Celgene (C)</p> Signup and view all the answers

What is keratosis senilis also known as?

<p>Senile keratoma (A)</p> Signup and view all the answers

What does AK stand for in medical terminology?

<p>Actinic keratosis (B)</p> Signup and view all the answers

Which statement describes SCC in relation to AK?

<p>AK is considered a precursor to SCC. (B)</p> Signup and view all the answers

Which of the following conditions is related to keratosis senilis?

<p>Senile keratoma (C)</p> Signup and view all the answers

What is pending regarding the recommendation of AK?

<p>Recommendation is pending in assessing SCC type AK. (C)</p> Signup and view all the answers

What is a key characteristic of randomized trials compared to cohort studies?

<p>They randomly assign participants to groups. (B)</p> Signup and view all the answers

Which type of study is best suited to determine the efficacy of an intervention?

<p>Randomized trial. (B)</p> Signup and view all the answers

What is the characteristic of a Grade 1 AK lesion according to the Olsen classification system?

<p>It is slightly palpable and more easily felt than seen. (D)</p> Signup and view all the answers

Which grade of AK lesion is described as very thick and hyperkeratotic?

<p>Grade 3 (D)</p> Signup and view all the answers

When assessing poor-quality studies, what might be a consequence?

<p>They can lead to misleading conclusions. (A)</p> Signup and view all the answers

How are grade 2 AK lesions described in the Olsen classification system?

<p>Moderately thick, easily seen and felt. (C)</p> Signup and view all the answers

What aspect of prognostic cohort studies is often scrutinized?

<p>The quality of data collection. (A)</p> Signup and view all the answers

How do cohort studies primarily gather data?

<p>By observing and following specific groups over time. (C)</p> Signup and view all the answers

What is the primary method used for clinically grading individual AK lesions?

<p>Olsen classification system (C)</p> Signup and view all the answers

Which feature distinguishes grade 3 lesions from grade 1 lesions in the Olsen classification?

<p>Thickness and hyperkeratosis (B)</p> Signup and view all the answers

What is the primary reason patients with AK should be educated about self-skin examination?

<p>To monitor for recurrences and new lesions (C)</p> Signup and view all the answers

Which factor is emphasized for patients at risk of AK?

<p>Sun protection and skin examination (D)</p> Signup and view all the answers

What type of carcinomas are patients with AK at risk of developing?

<p>Other types of keratinocyte carcinomas (C)</p> Signup and view all the answers

What key action should be taken for AK patients regarding their skin health?

<p>Undergo regular skin examinations (C)</p> Signup and view all the answers

Why is it important for AK patients to receive education on self-skin examination?

<p>To catch any new growths or changes early (D)</p> Signup and view all the answers

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Study Notes

Actinic Keratosis (AK) Overview

  • Known as 'keratosis senilis', 'senile keratoma', or 'keratoma senile'.
  • Considered a precancerous condition leading to squamous cell carcinoma (SCC).

Classification of AK Lesions

  • Clinically graded based on thickness using the Olsen classification system:
    • Grade 1: Slightly palpable, more easily felt than observed.
    • Grade 2: Moderately thick, easily seen and felt.
    • Grade 3: Very thick and hyperkeratotic.

Education and Management

  • Patients require education on self-skin examination techniques and sun protection.
  • Referrals for skin examinations are necessary due to high recurrence rates and potential for new lesions.
  • Common risk for developing other types of keratinocyte carcinomas.

Research and Funding

  • Various grants received from institutions such as Health Foundation Limburg, AbbVie, Amgen, Biontech, BMS, and Celgene.
  • Institutional affiliations include departments in Romania, Greece, and Italy focusing on Dermatology.

Diagnostic Techniques

  • Confocal microscopy and optical coherence tomography (OCT) are utilized for diagnosis and assessment of AK lesions.

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