Acidosis: Respiratory and Metabolic
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Questions and Answers

What is the normal HCO3‾ /H2CO3 ratio?

  • Equal to 20/1
  • Less than 20/1 (correct)
  • Greater than 20/1
  • Not mentioned in the text

What are the causes of metabolic acidosis?

  • Massive pneumonia
  • Severe bronchial asthma
  • Severe muscular exercise with production of large amounts of lactic acid (correct)
  • Depression of the respiratory center by toxins

In respiratory acidosis, what is the compensation mechanism by the kidneys?

  • Increase excretion of H + ion and increase reabsorption of HCO3 ‾ into the blood (correct)
  • Decrease excretion of H + ion and decrease reabsorption of HCO3 ‾ into the blood
  • Increase excretion of CO2 through the urine
  • No compensation by the kidneys

In uncompensated metabolic acidosis, what are the biochemical characteristics?

<p>[HCO3‾] normal, [H2CO3] increased and pH&lt; 7.35 (C), [HCO3‾] normal, [H2CO3] increased and pH&lt; 7.35 (D)</p> Signup and view all the answers

What is the effect of high protein diet on the production of acids?

<p>Increase production of acids like phosphoric, sulfuric and uric acids (A)</p> Signup and view all the answers

Which of the following conditions is characterized by increased production of ketone bodies?

<p>Severe uncontrolled diabetes mellitus (D)</p> Signup and view all the answers

What is the primary compensatory mechanism for acidosis mentioned in the text?

<p>Stimulation of the respiratory centre causing deep and rapid breathing (D)</p> Signup and view all the answers

What causes renal acidosis according to the text?

<p>Inability of the kidneys to excrete organic and inorganic acids formed inside the body (A)</p> Signup and view all the answers

What is the effect of increased ventilation as a compensatory mechanism for acidosis?

<p>Reduction in CO2 levels (B)</p> Signup and view all the answers

When does excessive loss of bases occur according to the text?

<p>In cases of severe vomiting and diarrhea (B)</p> Signup and view all the answers

Flashcards

What's the normal HCO3-/H2CO3 ratio?

The normal ratio of bicarbonate (HCO3-) to carbonic acid (H2CO3) in the blood is generally less than 20:1.

What causes metabolic acidosis?

Metabolic acidosis can be caused by the buildup of lactic acid, often due to intense physical activity.

How do kidneys compensate for respiratory acidosis?

In respiratory acidosis, the kidneys compensate by excreting more hydrogen ions (H+) and reabsorbing more bicarbonate (HCO3-) into the blood.

What are the biochemical characteristics of uncompensated metabolic acidosis?

In uncompensated metabolic acidosis, the bicarbonate level (HCO3-) remains normal, carbonic acid (H2CO3) increases, and the pH falls below 7.35.

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How does a high-protein diet affect acid production?

A high-protein diet increases the production of acids like phosphoric, sulfuric, and uric acids in the body.

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What condition is linked to increased ketone body production?

Severe uncontrolled diabetes mellitus is characterized by an increased production of ketone bodies, a type of acid.

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What's the main compensatory mechanism for acidosis?

The primary compensatory mechanism for acidosis is stimulating the respiratory center, resulting in deep and rapid breathing.

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What causes renal acidosis?

Renal acidosis occurs when the kidneys are unable to effectively eliminate organic and inorganic acids produced by the body.

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How does increased ventilation compensate for acidosis?

Increased ventilation as a compensatory mechanism for acidosis helps reduce carbon dioxide (CO2) levels in the blood.

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When does excessive loss of bases occur?

Excessive loss of bases, like bicarbonate (HCO3-), can occur in cases of severe vomiting and diarrhea.

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Study Notes

Acid-Base Balance

  • The normal HCO₃⁻/H₂CO₃ ratio is 20:1.

Causes of Metabolic Acidosis

  • Causes of metabolic acidosis include: • Increased production of acids (e.g., high protein diet) • Excessive loss of bases (e.g., diarrhea) • Renal acidosis (kidney disease)

Respiratory Acidosis Compensation

  • In respiratory acidosis, the kidneys compensate by increasing HCO₃⁻ reabsorption and H⁺ secretion.

Metabolic Acidosis Characteristics

  • In uncompensated metabolic acidosis, biochemical characteristics include: • Decreased pH • Decreased HCO₃⁻ • Increased anion gap

Effects of Diet and Ketone Bodies

  • High protein diet increases acid production.
  • Conditions characterized by increased production of ketone bodies include diabetic ketoacidosis.

Compensatory Mechanisms for Acidosis

  • The primary compensatory mechanism for acidosis is respiratory compensation (increased ventilation).
  • Increased ventilation helps to remove excess CO₂ and increase pH.

Renal Acidosis

  • Renal acidosis is caused by kidney disease, which impairs the kidneys' ability to regulate acid-base balance.

Excessive Loss of Bases

  • Excessive loss of bases occurs in conditions such as diarrhea.

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Description

This quiz covers the concept of acidosis, focusing on its two classifications: respiratory and metabolic. It includes causes, compensation mechanisms, and related conditions.

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