Podcast
Questions and Answers
Which toxin inhibits ACh release at a typical ACh synapse?
Which toxin inhibits ACh release at a typical ACh synapse?
- Tacrine
- Botulinus toxin (correct)
- Varenicline
- Black widow spider toxin
Which drug is a partial agonist at nicotinic receptors?
Which drug is a partial agonist at nicotinic receptors?
- Tacrine
- Varenicline (correct)
- Benztropine
- Curare
Which compound inhibits the choline transporter in a typical ACh synapse?
Which compound inhibits the choline transporter in a typical ACh synapse?
- Hemicholinium (correct)
- Arecoline
- Reserpine
- Atropine
What is the mechanism of action of SSRI and SNRI antidepressants in a serotonergic synapse?
What is the mechanism of action of SSRI and SNRI antidepressants in a serotonergic synapse?
Which drug is used as a 5HT3 antagonist in a serotonergic synapse?
Which drug is used as a 5HT3 antagonist in a serotonergic synapse?
Which compound inhibits the enzyme tryptophan hydrolase, affecting serotonin synthesis?
Which compound inhibits the enzyme tryptophan hydrolase, affecting serotonin synthesis?
What does reserpine inhibit in both dopamine and norepinephrine synapses?
What does reserpine inhibit in both dopamine and norepinephrine synapses?
Which drug increases dopamine release via the dopamine transporter?
Which drug increases dopamine release via the dopamine transporter?
What is the role of tropolone in both dopaminergic and noradrenergic synapses?
What is the role of tropolone in both dopaminergic and noradrenergic synapses?
What is the effect of most antipsychotic drugs on dopamine receptors?
What is the effect of most antipsychotic drugs on dopamine receptors?
Which of the following is a D2 agonist?
Which of the following is a D2 agonist?
What type of drug is propranolol?
What type of drug is propranolol?
Study Notes
ACh Synapse
- Botulinus and tetanus toxins inhibit acetylcholine (ACh) release, whereas black widow spider toxin stimulates ACh release
- Tacrine and physostigmine inhibit acetylcholinesterase (AChE)
- Curare and mecamylamine are nicotinic antagonists
- Varenicline is a partial agonist at nicotinic receptors
- Vesamicol inhibits the vesicular acetylcholine transporter
- Hemicholinium inhibits the choline transporter
- Arecoline is a muscarinic agonist
- Atropine and benztropine are muscarinic antagonists
5HT Synapse
- Reserpine inhibits VMAT and depletes serotonin stores
- SSRI and SNRI antidepressants inhibit the serotonin transporter
- Many antipsychotic drugs inhibit 5HT2A receptors
- Odansetron is a 5HT3 antagonist
- PCPA inhibits tryptophan hydrolase and serotonin synthesis
- Antimigraine triptans are 5HT1B/1D agonists
- MAOI antidepressants inhibit MAOA
- Buspirone is a partial agonist at 5HT1A receptors
Dopamine Synapse
- Reserpine inhibits VMAT and depletes dopamine stores
- Cocaine inhibits the dopamine transporter
- Amphetamine increases dopamine release via the transporter
- Pramipexole is a partial D2 agonist
- Tropolone inhibits COMT
- AMPT inhibits tyrosine hydroxrolase and dopamine synthesis
- Selegiline inhibits MAOB
- Most antipsychotic drugs block D2 receptors
- Aripiprazole is a partial D2 agonist
- Bromocriptine is a D2 agonist
Norepinephrine Synapse
- Reserpine inhibits VMAT and depletes norepinephrine stores
- NRI and SNRI antidepressants inhibit the norepinephrine transporter
- Tropolone inhibits COMT
- AMPT inhibits tyrosine hydroxylase and norepinephrine synthesis
- MAOI antidepressants inhibit MAOA
- Yohimbine is an α2 antagonist
- Clonidine is an α2 agonist
- Propranolol is a β antagonist
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Description
This quiz is about the Ach synapse and its relation to various toxins, inhibitors, and agonists. It covers the effects of different substances on acetylcholine release and receptors.
