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Questions and Answers
What is the primary function of acetylsalicylic acid (Aspirin)?
What is the primary function of acetylsalicylic acid (Aspirin)?
Which adverse effect is associated with Aspirin?
Which adverse effect is associated with Aspirin?
How do steroids differ from nonsteroidal anti-inflammatory drugs in terms of side effects?
How do steroids differ from nonsteroidal anti-inflammatory drugs in terms of side effects?
Which enzyme does Aspirin inhibit to reduce inflammation?
Which enzyme does Aspirin inhibit to reduce inflammation?
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Which drug is mentioned as inhibiting COX-2 only?
Which drug is mentioned as inhibiting COX-2 only?
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How does the serum half-life of Aspirin vary with the dose?
How does the serum half-life of Aspirin vary with the dose?
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What are the signs of chronic aspirin toxicity?
What are the signs of chronic aspirin toxicity?
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Which group of individuals may not experience otic symptoms in case of chronic aspirin toxicity?
Which group of individuals may not experience otic symptoms in case of chronic aspirin toxicity?
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What is the most common sign of aspirin overdose in infants, young children, and patients with preexisting hearing loss?
What is the most common sign of aspirin overdose in infants, young children, and patients with preexisting hearing loss?
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What acid-base disturbance is likely to predominate in cases of aspirin overdose?
What acid-base disturbance is likely to predominate in cases of aspirin overdose?
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What toxic effect of aspirin can result in hepatotoxicity leading to fulminant hepatic failure?
What toxic effect of aspirin can result in hepatotoxicity leading to fulminant hepatic failure?
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Which method provides the highest analytic sensitivity and specificity for quantifying aspirin?
Which method provides the highest analytic sensitivity and specificity for quantifying aspirin?
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Study Notes
Acetylsalicylic acid (Aspirin)
- Primary function: Analgesic, antipyretic, and anti-inflammatory properties.
- Adverse effect: Gastrointestinal irritation, including ulcers, bleeding, and dyspepsia.
- Mechanism of Action: Aspirin inhibits the enzyme cyclooxygenase (COX), specifically COX-1 and COX-2, to reduce inflammation.
Steroid vs. Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
- Steroids can cause fluid retention, sodium retention, increased appetite, and weight gain, while NSAIDs are associated with gastrointestinal irritation and bleeding.
COX-2 Inhibitor
- Celecoxib is mentioned as a drug that inhibits COX-2 only.
Aspirin Dose and Half-Life
- Aspirin's serum half-life varies with the dose. Higher doses lead to longer half-lives.
Chronic Aspirin Toxicity
- Signs: Tinnitus (ringing in the ears), hearing loss, dizziness, hyperventilation, and metabolic acidosis.
- Individuals with preexisting hearing loss may not experience otic symptoms (tinnitus and hearing loss).
- Most common sign in infants, young children, and those with preexisting hearing loss: Hyperventilation.
Aspirin Overdose
- Acid-base disturbance: Metabolic acidosis predominates.
- Toxic effect: Salicylate toxicity can lead to hepatotoxicity resulting in fulminant hepatic failure.
Aspirin Quantification
- Method: High-performance liquid chromatography (HPLC) is the most sensitive and specific method for quantifying aspirin in biological samples.
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Description
Test your knowledge about Acetylsalicylic Acid (Aspirin) MLS 111B, a nonsteroidal anti-inflammatory compound used for pain relief and inflammation. Learn about its uses, adverse effects, and effectiveness in treating various conditions.
