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Questions and Answers
What are the two main precursors used for synthesizing acetylcholine (ACh)?
What are the two main precursors used for synthesizing acetylcholine (ACh)?
acetyl-CoA and choline
Which enzyme is responsible for the synthesis of acetylcholine (ACh)?
Which enzyme is responsible for the synthesis of acetylcholine (ACh)?
Choline Acetyltransferase (ChAT)
How is acetylcholine (ACh) transported into the neuron terminal?
How is acetylcholine (ACh) transported into the neuron terminal?
via a sodium-dependent membrane choline transporter
By what process does acetylcholine (ACh) enter the vesicles?
By what process does acetylcholine (ACh) enter the vesicles?
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Which substance can block the sodium-dependent membrane choline transporter?
Which substance can block the sodium-dependent membrane choline transporter?
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Study Notes
Acetylcholine Synthesis
- Acetylcholine (ACh) is synthesized in the cytoplasm from two precursors: acetyl-CoA and choline.
- The enzyme responsible for synthesizing ACh is Choline Acetyltransferase (ChAT).
Acetylcholine Transport
- ACh is transported into the neuron terminal via a sodium-dependent membrane choline transporter.
- This transporter can be blocked by a specific type of inhibitor called hemicholiniums.
- ACh is also transported into vesicles via a vesicle-associated transporter.
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