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Questions and Answers
What are the two main precursors used for synthesizing acetylcholine (ACh)?
acetyl-CoA and choline
Which enzyme is responsible for the synthesis of acetylcholine (ACh)?
Choline Acetyltransferase (ChAT)
How is acetylcholine (ACh) transported into the neuron terminal?
via a sodium-dependent membrane choline transporter
By what process does acetylcholine (ACh) enter the vesicles?
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Which substance can block the sodium-dependent membrane choline transporter?
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Study Notes
Acetylcholine Synthesis
- Acetylcholine (ACh) is synthesized in the cytoplasm from two precursors: acetyl-CoA and choline.
- The enzyme responsible for synthesizing ACh is Choline Acetyltransferase (ChAT).
Acetylcholine Transport
- ACh is transported into the neuron terminal via a sodium-dependent membrane choline transporter.
- This transporter can be blocked by a specific type of inhibitor called hemicholiniums.
- ACh is also transported into vesicles via a vesicle-associated transporter.
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Description
Learn about the synthesis of Acetylcholine, a neurotransmitter, and its transport mechanisms in neurons. Understand the role of enzymes and transporters in this process.
