Podcast
Questions and Answers
What is the primary function of succinyl-CoA synthetase in the TCA cycle?
What is the primary function of succinyl-CoA synthetase in the TCA cycle?
Which of the following statements accurately describes substrate-level phosphorylation?
Which of the following statements accurately describes substrate-level phosphorylation?
During which process is carbon dioxide primarily released?
During which process is carbon dioxide primarily released?
What is a major difference between substrate-level phosphorylation and oxidative phosphorylation?
What is a major difference between substrate-level phosphorylation and oxidative phosphorylation?
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Which molecule is primarily responsible for energy release in the TCA cycle?
Which molecule is primarily responsible for energy release in the TCA cycle?
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What role does pyruvate play in cellular respiration?
What role does pyruvate play in cellular respiration?
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Which of these molecules is NOT directly produced during the TCA cycle?
Which of these molecules is NOT directly produced during the TCA cycle?
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What characterizes the energy yield of substrate-level phosphorylation compared to oxidative phosphorylation?
What characterizes the energy yield of substrate-level phosphorylation compared to oxidative phosphorylation?
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What is the primary product of acetyl-CoA during the Citric Acid Cycle?
What is the primary product of acetyl-CoA during the Citric Acid Cycle?
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Which substrate is NOT a primary source for the production of acetyl-CoA?
Which substrate is NOT a primary source for the production of acetyl-CoA?
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How many molecules of CO2 are released in total from the complete oxidation of one glucose molecule?
How many molecules of CO2 are released in total from the complete oxidation of one glucose molecule?
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What is the primary function of acetyl-CoA in cellular metabolism?
What is the primary function of acetyl-CoA in cellular metabolism?
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During which metabolic process is acetyl-CoA converted into ketone bodies?
During which metabolic process is acetyl-CoA converted into ketone bodies?
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Which process describes the conversion of pyruvate to acetyl-CoA?
Which process describes the conversion of pyruvate to acetyl-CoA?
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What is the total yield of ATP from one rotation of the TCA cycle, considering both substrate-level phosphorylation and oxidative phosphorylation?
What is the total yield of ATP from one rotation of the TCA cycle, considering both substrate-level phosphorylation and oxidative phosphorylation?
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During the TCA cycle, CO2 is released during which transformations of the cycle?
During the TCA cycle, CO2 is released during which transformations of the cycle?
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Which of the following is NOT a biosynthetic role of acetyl-CoA?
Which of the following is NOT a biosynthetic role of acetyl-CoA?
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Which statement about the TCA cycle is true?
Which statement about the TCA cycle is true?
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Which molecule is NOT produced during the TCA cycle?
Which molecule is NOT produced during the TCA cycle?
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What is generated from each NADH molecule during oxidative phosphorylation?
What is generated from each NADH molecule during oxidative phosphorylation?
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Which of the following is a correct consequence of acetyl-CoA’s involvement in biosynthesis?
Which of the following is a correct consequence of acetyl-CoA’s involvement in biosynthesis?
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Study Notes
Acetyl-CoA Overview
- Acetyl-CoA is a fundamental intermediate in cellular metabolism, integral for energy production and biosynthesis.
- Functions primarily as a two-carbon unit essential for various metabolic pathways.
Energy Production
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TCA Cycle (Citric Acid Cycle):
- Acetyl-CoA enters the TCA cycle, leading to the formation of ATP, NADH, and FADH2.
- NADH and FADH2 are crucial for the electron transport chain, resulting in further ATP generation.
- One cycle yields one ATP (or GTP) via substrate-level phosphorylation but supports significant ATP synthesis through oxidative phosphorylation.
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Ketone Body Formation:
- In prolonged fasting or diabetes, acetyl-CoA converts into ketone bodies (acetoacetate, β-hydroxybutyrate, acetone) for alternative fuel, particularly for the brain.
Biosynthesis
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Fatty Acid Synthesis:
- Serves as the precursor for fatty acids, vital for cell membranes and energy storage.
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Cholesterol Synthesis:
- Functions as a precursor for cholesterol, crucial for cell membranes and steroid hormones.
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Amino Acid Synthesis:
- Certain amino acids can be synthesized from acetyl-CoA and its derivatives.
Substrate-Level Phosphorylation in TCA Cycle
- Occurs exclusively in the mitochondrial matrix of eukaryotic cells.
- Only substrate-level phosphorylation in the TCA involves succinyl-CoA synthetase, producing GTP or ATP from succinyl-CoA.
- No substrate-level phosphorylation occurs in the cytosol during the TCA cycle.
Pyruvate Oxidation and CO2 Release
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Pyruvate Conversion:
- Pyruvate (3-carbon molecule from glycolysis) is converted to acetyl-CoA in mitochondria, releasing CO2 and NADH.
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TCA Cycle CO2 Production:
- For each acetyl-CoA, two CO2 molecules are released during isocitrate to α-ketoglutarate and α-ketoglutarate to succinyl-CoA conversions.
- Complete glucose oxidation releases six CO2 molecules: two from pyruvate oxidation and four from the TCA cycle.
Acetyl-CoA Production Sources
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Pyruvate:
- Primary source; produced from glycolysis and converted via the pyruvate dehydrogenase complex in mitochondria.
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Fatty Acids:
- Broken down by β-oxidation producing acetyl-CoA in mitochondria.
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Amino Acids:
- Ketogenic amino acids can convert to acetyl-CoA, particularly in the liver.
Conclusion
- Acetyl-CoA is a versatile metabolite central to energy metabolism and biosynthesis, derived from pyruvate, fatty acids, and certain amino acids, adapting to cellular metabolic needs.
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Description
This quiz explores the crucial role of Acetyl-CoA in cellular metabolism, including its function in energy production through the TCA cycle and ketone body formation. Additionally, it covers its significance in biosynthesis, such as fatty acid and cholesterol synthesis. Test your knowledge on this essential metabolic intermediate.
