8 Questions
Which molecule is exported to the cytosol for the production of cytosolic acetyl CoA and oxaloacetate?
Citrate
What is the fate of excess acetyl CoA in the mitochondrial matrix when isocitrate dehydrogenase is inhibited by large amounts of ATP?
It is converted to citrate
What enzyme cleaves citrate in the cytosol to produce acetyl CoA and oxaloacetate?
ATP-citrate lyase
What is the role of citrate in the transport of acetyl CoA?
It acts as a transporter for acetyl CoA
What is the product of the cleavage of citrate by ATP-citrate lyase in the cytosol?
Acetyl CoA and oxaloacetate
What is the effect of high ATP concentrations on isocitrate dehydrogenase?
It is inhibited
What is the purpose of cleaving citrate to produce acetyl CoA in the cytosol?
To use in fatty acid synthesis
What is the carbon content of acetyl CoA produced from the cleavage of citrate?
2 carbon
"Test Your Knowledge on Mitochondrial Citrate and Acetyl CoA Metabolism" - Take this quiz to enhance your understanding of how citrate is exported from the mitochondria and cleaved to produce cytosolic acetyl CoA and oxaloacetate. Learn about the role of ATP-citrate lyase and how the inhibition of isocitrate dehydrogenase affects mitochondrial citrate concentration. Test your knowledge on the transport of acetyl CoA across the inner mitochondrial
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