How Well Do You Know Mitochondrial Citrate and Acetyl CoA Metabolism?
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Questions and Answers

Which molecule is exported to the cytosol for the production of cytosolic acetyl CoA and oxaloacetate?

  • Acetyl CoA
  • Citrate (correct)
  • Isocitrate
  • Oxaloacetate

What is the fate of excess acetyl CoA in the mitochondrial matrix when isocitrate dehydrogenase is inhibited by large amounts of ATP?

  • It is used for fatty acid synthesis
  • It is converted to citrate (correct)
  • It is transported to the cytosol
  • It accumulates in the mitochondrial matrix

What enzyme cleaves citrate in the cytosol to produce acetyl CoA and oxaloacetate?

  • Isocitrate dehydrogenase
  • ATP-citrate lyase (correct)
  • Citrate synthase
  • Fatty acid synthase

What is the role of citrate in the transport of acetyl CoA?

<p>It acts as a transporter for acetyl CoA (C)</p> Signup and view all the answers

What is the product of the cleavage of citrate by ATP-citrate lyase in the cytosol?

<p>Acetyl CoA and oxaloacetate (B)</p> Signup and view all the answers

What is the effect of high ATP concentrations on isocitrate dehydrogenase?

<p>It is inhibited (A)</p> Signup and view all the answers

What is the purpose of cleaving citrate to produce acetyl CoA in the cytosol?

<p>To use in fatty acid synthesis (D)</p> Signup and view all the answers

What is the carbon content of acetyl CoA produced from the cleavage of citrate?

<p>2 carbon (B)</p> Signup and view all the answers

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