ACE Inhibitors and Angioedema

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Questions and Answers

What is the primary mechanism by which ACE inhibitors lower blood pressure?

By promoting vasoconstriction
By increasing heart rate
By inhibiting the renin-angiotensin-aldosterone system (correct)
By increasing blood volume

Which initial symptoms may indicate the onset of angioedema caused by ACE inhibitors?

Itchy lips and tongue (correct)
Swollen joints
Rash on the abdomen
Persistent cough

What severe complication can angioedema lead to if not treated promptly?

Cerebral hemorrhage
Cardiac arrest
Airway obstruction and respiratory failure (correct)
Severe hypertension

Angioedema associated with ACE inhibitors results from the accumulation of which substance?

<p>Bradykinin (B)</p> Signup and view all the answers

What effect does bradykinin have in the body?

<p>It promotes vasodilation (C)</p> Signup and view all the answers

Flashcards

ACE Inhibitors

A group of medications that lower blood pressure by blocking the renin-angiotensin-aldosterone system (RAAS).

Angioedema

A severe side effect of ACE inhibitors that involves swelling of the face, lips, tongue, or throat. It can progress to airway obstruction and respiratory failure.

Bradykinin

A hormone that causes blood vessels to widen, increasing blood flow.

Renin-Angiotensin-Aldosterone System (RAAS)

The system responsible for controlling blood pressure and water balance in the body. ACE inhibitors block this system.

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How ACE inhibitors cause angioedema?

ACE inhibitors prevent the breakdown of bradykinin, leading to its accumulation in the body. This can trigger the immune and inflammatory response that causes angioedema.

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Study Notes

ACE Inhibitors

ACE inhibitors, such as lisinopril and benazepril, lower blood pressure by inhibiting the renin-angiotensin-aldosterone system (RAAS).

Angioedema

Itchy lips and tongue are initial symptoms of angioedema, a severe side effect of ACE inhibitors.
Angioedema can lead to airway obstruction and respiratory failure if not treated promptly.
Angioedema is caused by the inhibition of bradykinin breakdown.
Bradykinin is a vasodilator.
Increased bradykinin levels trigger an immune and inflammatory response.
Swelling of the face, lips, tongue, or throat can result.