Intergrated Cancer
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Questions and Answers

Which one of the following chemicals is not carcinogenic?

  • Aflatoxin
  • Benzo(a)pyrene (a polycylic aromatic hydrocarbon)
  • Chrysene
  • Ascorbic acid (correct)
  • Which one of the following descriptions of active wild-type p53 protein is incorrect?

  • p53 is encoded by an oncogene (correct)
  • p53 regulates the cell cycle
  • p53 is a tumour suppressor protein
  • p53 regulates DNA repair
  • Cancer cells do not display which of the following

  • Invasion and metastasis
  • Uncontrolled proliferation
  • Contact-inhibited growth (correct)
  • Insensitive to growth inhibitory signals
  • Which one of the following symptoms is NOT a paraneoplastic manifestation of tumours

    <p>Obstruction</p> Signup and view all the answers

    The Epstein-Barr virus is most likely associated with which of the following?

    <p>Burkitt's lymphoma</p> Signup and view all the answers

    Human papilloma virus (HPV) is most likely associated with which of the following?

    <p>Cervical cancer</p> Signup and view all the answers

    Which of the following is an increase in tissue mass resulting from an increase in the size of its constituent cells?

    <p>Hypertrophy</p> Signup and view all the answers

    Which of the following mechanisms might not be associated with oncogene activation?

    <p>Silent mutations in the coding regions of exons or in introns</p> Signup and view all the answers

    Which of the following is not local effect due to the growth of tumour?

    <p>Cachexia</p> Signup and view all the answers

    Which statement about Xeroderma Pigmentosum (XP) is false?

    <p>XP involves female only</p> Signup and view all the answers

    Telomerase

    <p>is switched on in cancer cells</p> Signup and view all the answers

    The active wild-type p53 protein normally promotes which one of the following:

    <p>cell apoptosis</p> Signup and view all the answers

    When cancer causes clinical syndromes NOT as a result of its metastasis or local tissue invasion, this is termed as:

    <p>Paraneoplastic syndrome</p> Signup and view all the answers

    Which one of the following is NOT a characteristic of cancer cells?

    <p>undergoing apoptosis</p> Signup and view all the answers

    BRCA1 is most likely associated with which one of the following types of cancer?

    <p>Breast cancer</p> Signup and view all the answers

    About 50% of all human cancers may involve an abnormal or missing

    <p>p53 gene</p> Signup and view all the answers

    Which one of the following compounds is associated with increased risk of liver cancer?

    <p>aflatoxin</p> Signup and view all the answers

    BRCA1 mutation is most likely associated with which one of the following types of cancer?

    <p>ovarian cancer</p> Signup and view all the answers

    Which statement about PSA (prostate-specific antigen) is incorrect?

    <p>PSA concentrations in the blood can be used to distinguish between prostate cancer and non- cancerous conditions</p> Signup and view all the answers

    When cancer causes clinical syndromes NOT as a result of its metastasis or local tissue invasion, this is termed as:

    <p>Paraneoplastic syndrome</p> Signup and view all the answers

    Which of these is the incrase in tissue mass after cell divison

    <p>Hyperplasia</p> Signup and view all the answers

    The formation of an inherited retinoblastoma is associated with the mutations of:

    <p>RB (Rb) gene</p> Signup and view all the answers

    Which one of the following statement is incorrect?

    <p>RANK ligand (RANKL) released by myeloma cells stimulates osteoblasts that contribute to hypercalcemia</p> Signup and view all the answers

    Which one of the following tumour markers is most likely associated with breast cancer?

    <p>cancer antigen 15-3 (CA 15-3)</p> Signup and view all the answers

    All of the following effects are disadvantages of anticancer drugs, EXCEPT

    <p>Depression of angiogenesis</p> Signup and view all the answers

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