Intergrated Cancer

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Questions and Answers

Which one of the following chemicals is not carcinogenic?

  • Aflatoxin
  • Benzo(a)pyrene (a polycylic aromatic hydrocarbon)
  • Chrysene
  • Ascorbic acid (correct)

Which one of the following descriptions of active wild-type p53 protein is incorrect?

  • p53 is encoded by an oncogene (correct)
  • p53 regulates the cell cycle
  • p53 is a tumour suppressor protein
  • p53 regulates DNA repair

Cancer cells do not display which of the following

  • Invasion and metastasis
  • Uncontrolled proliferation
  • Contact-inhibited growth (correct)
  • Insensitive to growth inhibitory signals

Which one of the following symptoms is NOT a paraneoplastic manifestation of tumours

<p>Obstruction (B)</p> Signup and view all the answers

The Epstein-Barr virus is most likely associated with which of the following?

<p>Burkitt's lymphoma (D)</p> Signup and view all the answers

Human papilloma virus (HPV) is most likely associated with which of the following?

<p>Cervical cancer (D)</p> Signup and view all the answers

Which of the following is an increase in tissue mass resulting from an increase in the size of its constituent cells?

<p>Hypertrophy (D)</p> Signup and view all the answers

Which of the following mechanisms might not be associated with oncogene activation?

<p>Silent mutations in the coding regions of exons or in introns (B)</p> Signup and view all the answers

Which of the following is not local effect due to the growth of tumour?

<p>Cachexia (C)</p> Signup and view all the answers

Which statement about Xeroderma Pigmentosum (XP) is false?

<p>XP involves female only (D)</p> Signup and view all the answers

Telomerase

<p>is switched on in cancer cells (D)</p> Signup and view all the answers

The active wild-type p53 protein normally promotes which one of the following:

<p>cell apoptosis (B)</p> Signup and view all the answers

When cancer causes clinical syndromes NOT as a result of its metastasis or local tissue invasion, this is termed as:

<p>Paraneoplastic syndrome (D)</p> Signup and view all the answers

Which one of the following is NOT a characteristic of cancer cells?

<p>undergoing apoptosis (A)</p> Signup and view all the answers

BRCA1 is most likely associated with which one of the following types of cancer?

<p>Breast cancer (C)</p> Signup and view all the answers

About 50% of all human cancers may involve an abnormal or missing

<p>p53 gene (B)</p> Signup and view all the answers

Which one of the following compounds is associated with increased risk of liver cancer?

<p>aflatoxin (A)</p> Signup and view all the answers

BRCA1 mutation is most likely associated with which one of the following types of cancer?

<p>ovarian cancer (A)</p> Signup and view all the answers

Which statement about PSA (prostate-specific antigen) is incorrect?

<p>PSA concentrations in the blood can be used to distinguish between prostate cancer and non- cancerous conditions (A)</p> Signup and view all the answers

When cancer causes clinical syndromes NOT as a result of its metastasis or local tissue invasion, this is termed as:

<p>Paraneoplastic syndrome (A)</p> Signup and view all the answers

Which of these is the incrase in tissue mass after cell divison

<p>Hyperplasia (A)</p> Signup and view all the answers

The formation of an inherited retinoblastoma is associated with the mutations of:

<p>RB (Rb) gene (A)</p> Signup and view all the answers

Which one of the following statement is incorrect?

<p>RANK ligand (RANKL) released by myeloma cells stimulates osteoblasts that contribute to hypercalcemia (D)</p> Signup and view all the answers

Which one of the following tumour markers is most likely associated with breast cancer?

<p>cancer antigen 15-3 (CA 15-3) (A)</p> Signup and view all the answers

All of the following effects are disadvantages of anticancer drugs, EXCEPT

<p>Depression of angiogenesis (C)</p> Signup and view all the answers

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