Podcast
Questions and Answers
A patient presents with chronic lower back pain and stiffness, particularly in the morning. Imaging reveals sacroiliitis. Which of the following conditions is the most likely diagnosis?
A patient presents with chronic lower back pain and stiffness, particularly in the morning. Imaging reveals sacroiliitis. Which of the following conditions is the most likely diagnosis?
- Spondylolisthesis
- Ankylosing spondylitis (correct)
- Rheumatoid arthritis
- Gout
Which lifestyle modification would be LEAST appropriate for managing a patient's acute gout flare-up?
Which lifestyle modification would be LEAST appropriate for managing a patient's acute gout flare-up?
- Reducing alcohol consumption
- Initiating a high-intensity exercise program (correct)
- Achieving and maintaining a healthy weight
- Increasing daily water intake
A physician suspects a meniscal tear in a patient following a knee injury. Which imaging modality is MOST suitable for evaluating soft tissue damage in this scenario?
A physician suspects a meniscal tear in a patient following a knee injury. Which imaging modality is MOST suitable for evaluating soft tissue damage in this scenario?
- X-ray
- Ultrasound
- Computed Tomography (CT)
- Magnetic Resonance Imaging (MRI) (correct)
A patient taking bisphosphonates for osteoporosis reports experiencing persistent heartburn and chest pain. Which of the following instructions is MOST important to provide this patient regarding their medication?
A patient taking bisphosphonates for osteoporosis reports experiencing persistent heartburn and chest pain. Which of the following instructions is MOST important to provide this patient regarding their medication?
Which of the following pathophysiologic responses is LEAST likely to be directly induced by smoking?
Which of the following pathophysiologic responses is LEAST likely to be directly induced by smoking?
A patient presents with edema, weight loss, and diminished functional capacity. Which nutritional deficiency is MOST likely contributing to these symptoms?
A patient presents with edema, weight loss, and diminished functional capacity. Which nutritional deficiency is MOST likely contributing to these symptoms?
Which of the following mechanisms describes the intrinsic healing process in a tendon?
Which of the following mechanisms describes the intrinsic healing process in a tendon?
Which of the following factors involved in mechanical tissue injury is MOST directly related to the number of times a tissue is subjected to a stress?
Which of the following factors involved in mechanical tissue injury is MOST directly related to the number of times a tissue is subjected to a stress?
Following a viral infection, a cell undergoes direct injury due to the virus's presence. Which type of virus is MOST likely responsible for this direct effect?
Following a viral infection, a cell undergoes direct injury due to the virus's presence. Which type of virus is MOST likely responsible for this direct effect?
Which of the following is the MOST accurate description of necrosis?
Which of the following is the MOST accurate description of necrosis?
Prolonged ischemia deprives tissues of oxygen, potentially leading to irreversible cell injury. Which of the following processes is MOST likely to occur as a direct result of irreversible cell injury?
Prolonged ischemia deprives tissues of oxygen, potentially leading to irreversible cell injury. Which of the following processes is MOST likely to occur as a direct result of irreversible cell injury?
A patient is diagnosed with neuropathy due to a nutritional deficiency. Which specific vitamin deficiency is MOST likely the cause?
A patient is diagnosed with neuropathy due to a nutritional deficiency. Which specific vitamin deficiency is MOST likely the cause?
Which factor is MOST important when considering the likelihood of a mechanical injury to a tissue?
Which factor is MOST important when considering the likelihood of a mechanical injury to a tissue?
What is the MOST critical factor influencing the degree of tendon healing following an injury?
What is the MOST critical factor influencing the degree of tendon healing following an injury?
During which stage of tendon healing is the tendon repair the WEAKEST, making it most vulnerable to re-injury?
During which stage of tendon healing is the tendon repair the WEAKEST, making it most vulnerable to re-injury?
Why is complete unloading or overloading detrimental to tendon healing?
Why is complete unloading or overloading detrimental to tendon healing?
Which of the following rehabilitation approaches would be MOST beneficial for flexor tendon healing?
Which of the following rehabilitation approaches would be MOST beneficial for flexor tendon healing?
What is the primary reason intra-articular ligaments, such as the ACL, often do not heal spontaneously after a complete tear?
What is the primary reason intra-articular ligaments, such as the ACL, often do not heal spontaneously after a complete tear?
After an MCL tear, what is the rationale behind applying progressive, controlled stress during the remodeling phase of healing?
After an MCL tear, what is the rationale behind applying progressive, controlled stress during the remodeling phase of healing?
A researcher is determining the LD50 of a new analgesic in mice. After administering various doses, they observe that 50% of the mice die at a dose of 150mg/kg. What does this LD50 value indicate?
A researcher is determining the LD50 of a new analgesic in mice. After administering various doses, they observe that 50% of the mice die at a dose of 150mg/kg. What does this LD50 value indicate?
Which of the following represents an extra-articular ligament?
Which of the following represents an extra-articular ligament?
A patient with a history of cardiovascular disease is experiencing mild to moderate pain and inflammation due to osteoarthritis. Considering the risks and benefits, which analgesic would be the MOST appropriate initial choice?
A patient with a history of cardiovascular disease is experiencing mild to moderate pain and inflammation due to osteoarthritis. Considering the risks and benefits, which analgesic would be the MOST appropriate initial choice?
What is the MOST important consideration when managing a patient with a ligament injury to ensure optimal healing and remodeling?
What is the MOST important consideration when managing a patient with a ligament injury to ensure optimal healing and remodeling?
A patient taking NSAIDs for chronic pain management develops persistent heartburn and epigastric pain. What is the MOST likely cause of these symptoms and what should be considered to mitigate it?
A patient taking NSAIDs for chronic pain management develops persistent heartburn and epigastric pain. What is the MOST likely cause of these symptoms and what should be considered to mitigate it?
Which of the following beneficial effects is UNIQUE to NSAIDs compared to acetaminophen (Tylenol)?
Which of the following beneficial effects is UNIQUE to NSAIDs compared to acetaminophen (Tylenol)?
A patient is diagnosed with osteomyelitis caused by a bacterial infection. What is the MOST important pharmacological intervention that should be initiated?
A patient is diagnosed with osteomyelitis caused by a bacterial infection. What is the MOST important pharmacological intervention that should be initiated?
A patient undergoing long-term glucocorticoid treatment for myositis is MOST at risk for developing which of the following adverse effects?
A patient undergoing long-term glucocorticoid treatment for myositis is MOST at risk for developing which of the following adverse effects?
A patient being treated for osteomyelitis with fluoroquinolone antibiotics reports sudden pain and swelling in their Achilles tendon after a routine walk. What is the MOST appropriate course of action?
A patient being treated for osteomyelitis with fluoroquinolone antibiotics reports sudden pain and swelling in their Achilles tendon after a routine walk. What is the MOST appropriate course of action?
A patient with myositis is prescribed a glucocorticoid. Which potential side effect should be closely monitored to prevent further complications?
A patient with myositis is prescribed a glucocorticoid. Which potential side effect should be closely monitored to prevent further complications?
When evaluating a conventional radiograph of a joint, a narrowed joint space suggests a potential issue with which of the following structures?
When evaluating a conventional radiograph of a joint, a narrowed joint space suggests a potential issue with which of the following structures?
A patient presents with localized increased bone density visible on a radiograph. This finding is most indicative of:
A patient presents with localized increased bone density visible on a radiograph. This finding is most indicative of:
During the reparative phase of fracture healing, which of the following processes primarily contributes to the stabilization of the fracture site?
During the reparative phase of fracture healing, which of the following processes primarily contributes to the stabilization of the fracture site?
A patient reports pain and limited range of motion after twisting their ankle. Examination reveals ecchymosis and moderate instability but no complete loss of function. This injury is most likely classified as what type of sprain?
A patient reports pain and limited range of motion after twisting their ankle. Examination reveals ecchymosis and moderate instability but no complete loss of function. This injury is most likely classified as what type of sprain?
Which of the following imaging modalities would be MOST appropriate for visualizing subtle changes in soft tissue structures, such as ligaments and tendons, in detail?
Which of the following imaging modalities would be MOST appropriate for visualizing subtle changes in soft tissue structures, such as ligaments and tendons, in detail?
A radiograph reveals a distinct, smooth margin at the epiphyseal plate with an adjacent sclerotic band. This finding is MOST indicative of:
A radiograph reveals a distinct, smooth margin at the epiphyseal plate with an adjacent sclerotic band. This finding is MOST indicative of:
Which of the following is the MOST radiopaque substance?
Which of the following is the MOST radiopaque substance?
A patient with a chronic injury displays pain symptoms disproportionate to the physical findings and reports significant discomfort regardless of position. This presentation may indicate:
A patient with a chronic injury displays pain symptoms disproportionate to the physical findings and reports significant discomfort regardless of position. This presentation may indicate:
A patient presents with a high fever, sudden drop in blood pressure, vomiting, diarrhea, confusion, and a rash resembling sunburn. Which condition is MOST likely indicated by these symptoms?
A patient presents with a high fever, sudden drop in blood pressure, vomiting, diarrhea, confusion, and a rash resembling sunburn. Which condition is MOST likely indicated by these symptoms?
Why do drugs administered sublingually bypass first-pass metabolism?
Why do drugs administered sublingually bypass first-pass metabolism?
Which route of drug administration provides the MOST rapid onset of action?
Which route of drug administration provides the MOST rapid onset of action?
What is a primary disadvantage of the oral route of drug administration?
What is a primary disadvantage of the oral route of drug administration?
Which pharmacokinetic process involves the removal of the drug from the body?
Which pharmacokinetic process involves the removal of the drug from the body?
A drug has a half-life of 4 hours. If the initial plasma concentration is 200 mg/L, how long will it take for the concentration to reach 50 mg/L?
A drug has a half-life of 4 hours. If the initial plasma concentration is 200 mg/L, how long will it take for the concentration to reach 50 mg/L?
What does the therapeutic index (TI) represent in drug safety?
What does the therapeutic index (TI) represent in drug safety?
Which route of administration is MOST suitable for achieving a prolonged drug release and steady plasma levels?
Which route of administration is MOST suitable for achieving a prolonged drug release and steady plasma levels?
A patient is prescribed a drug that is extensively metabolized by the liver. How might this affect the drug's bioavailability?
A patient is prescribed a drug that is extensively metabolized by the liver. How might this affect the drug's bioavailability?
Which route of drug administration is MOST likely to cause irritation of the rectal mucosa?
Which route of drug administration is MOST likely to cause irritation of the rectal mucosa?
If a drug is administered intravenously, what percentage of the drug is considered bioavailable?
If a drug is administered intravenously, what percentage of the drug is considered bioavailable?
A patient develops redness, swelling, pain, and warmth at the site of a skin infection, along with pus drainage. This presentation is MOST indicative of which condition?
A patient develops redness, swelling, pain, and warmth at the site of a skin infection, along with pus drainage. This presentation is MOST indicative of which condition?
Why is the intramuscular (IM) route suitable for depot drugs?
Why is the intramuscular (IM) route suitable for depot drugs?
What factor MOST significantly limits the use of transdermal drug delivery?
What factor MOST significantly limits the use of transdermal drug delivery?
A drug has a TD50 of 100 mg/kg and an ED50 of 10 mg/kg. What is its therapeutic index?
A drug has a TD50 of 100 mg/kg and an ED50 of 10 mg/kg. What is its therapeutic index?
A patient with rheumatoid arthritis (RA) is prescribed a DMARD. What is the PRIMARY goal of initiating DMARD therapy in this patient?
A patient with rheumatoid arthritis (RA) is prescribed a DMARD. What is the PRIMARY goal of initiating DMARD therapy in this patient?
A patient taking glucocorticoids reports experiencing proximal muscle weakness and easy fatigability. Which of the following adverse effects is MOST likely contributing to these symptoms?
A patient taking glucocorticoids reports experiencing proximal muscle weakness and easy fatigability. Which of the following adverse effects is MOST likely contributing to these symptoms?
Which of the following mechanisms describes how glucocorticoids exert their anti-inflammatory effects in the treatment of rheumatoid arthritis (RA)?
Which of the following mechanisms describes how glucocorticoids exert their anti-inflammatory effects in the treatment of rheumatoid arthritis (RA)?
A physical therapist is working with a patient who has been taking NSAIDs long-term for osteoarthritis. Which of the following potential side effects should the therapist be MOST aware of during treatment sessions?
A physical therapist is working with a patient who has been taking NSAIDs long-term for osteoarthritis. Which of the following potential side effects should the therapist be MOST aware of during treatment sessions?
Which of the following interventions is MOST important for a physical therapist to emphasize when treating a patient with a metabolic bone disorder?
Which of the following interventions is MOST important for a physical therapist to emphasize when treating a patient with a metabolic bone disorder?
A patient with osteoarthritis is considering viscosupplementation. What is the PRIMARY goal of this intervention?
A patient with osteoarthritis is considering viscosupplementation. What is the PRIMARY goal of this intervention?
A patient with rheumatoid arthritis (RA) has been prescribed glucocorticoids. Which potential side effect requires the MOST vigilant monitoring by the physical therapist during rehabilitation?
A patient with rheumatoid arthritis (RA) has been prescribed glucocorticoids. Which potential side effect requires the MOST vigilant monitoring by the physical therapist during rehabilitation?
A patient taking NSAIDs for chronic pain management develops hypertension. What is the MOST likely mechanism by which NSAIDs contribute to increased blood pressure?
A patient taking NSAIDs for chronic pain management develops hypertension. What is the MOST likely mechanism by which NSAIDs contribute to increased blood pressure?
A physical therapist is treating a patient with mild knee osteoarthritis who is taking NSAIDs for pain management. Which of the following adverse effects is MOST important for the therapist to monitor during treatment sessions?
A physical therapist is treating a patient with mild knee osteoarthritis who is taking NSAIDs for pain management. Which of the following adverse effects is MOST important for the therapist to monitor during treatment sessions?
A child recovering from a viral infection is prescribed medication for a persistent fever. Knowing the potential risks, which of the following medications should be AVOIDED due to the risk of Reye's syndrome?
A child recovering from a viral infection is prescribed medication for a persistent fever. Knowing the potential risks, which of the following medications should be AVOIDED due to the risk of Reye's syndrome?
A patient taking ciprofloxacin develops Achilles tendon pain after starting a running program. What is the MOST appropriate initial management strategy?
A patient taking ciprofloxacin develops Achilles tendon pain after starting a running program. What is the MOST appropriate initial management strategy?
A patient with a history of myocardial infarction (MI) is prescribed a non-opioid analgesic for chronic back pain. Which of the following considerations is MOST important when selecting a medication?
A patient with a history of myocardial infarction (MI) is prescribed a non-opioid analgesic for chronic back pain. Which of the following considerations is MOST important when selecting a medication?
Ms. Valhalla, a 58-year-old female, reports shoulder pain that is aggravated by overhead reaching and relieved by Meloxicam. Given this information, what is the MOST important next step in her evaluation?
Ms. Valhalla, a 58-year-old female, reports shoulder pain that is aggravated by overhead reaching and relieved by Meloxicam. Given this information, what is the MOST important next step in her evaluation?
A patient reports taking NSAIDs for pain relief but is concerned about potential side effects. Which statement BEST explains how NSAIDs exert their effects on inflammation and pain?
A patient reports taking NSAIDs for pain relief but is concerned about potential side effects. Which statement BEST explains how NSAIDs exert their effects on inflammation and pain?
Ms. Valhalla reports new pain between her shoulder blades and intermittent tingling in her left hand, which she attributes to walking her dog. What is the MOST appropriate interpretation of this new information?
Ms. Valhalla reports new pain between her shoulder blades and intermittent tingling in her left hand, which she attributes to walking her dog. What is the MOST appropriate interpretation of this new information?
During a physical therapy session, a patient on long-term NSAIDs reports sudden onset of severe abdominal pain. What is the MOST appropriate immediate action for the physical therapist?
During a physical therapy session, a patient on long-term NSAIDs reports sudden onset of severe abdominal pain. What is the MOST appropriate immediate action for the physical therapist?
Which of the following aspects of Ms. Valhalla's medical history presents a potential yellow flag warranting further consideration?
Which of the following aspects of Ms. Valhalla's medical history presents a potential yellow flag warranting further consideration?
A patient with a known hypersensitivity to aspirin needs an over-the-counter medication for fever and mild pain. Which of the following is the MOST appropriate recommendation?
A patient with a known hypersensitivity to aspirin needs an over-the-counter medication for fever and mild pain. Which of the following is the MOST appropriate recommendation?
A patient with osteoarthritis is taking NSAIDs to manage pain and inflammation. Which of the following statements BEST describes how NSAIDs alleviate these symptoms?
A patient with osteoarthritis is taking NSAIDs to manage pain and inflammation. Which of the following statements BEST describes how NSAIDs alleviate these symptoms?
Considering Ms. Valhalla's medical history, which medication presents the GREATEST potential to delay tendon healing should she sustain a tendon injury?
Considering Ms. Valhalla's medical history, which medication presents the GREATEST potential to delay tendon healing should she sustain a tendon injury?
A physical therapist is treating a patient on NSAIDs who reports easy bruising and prolonged bleeding after minor injuries. Which of the following mechanisms BEST explains this side effect of NSAIDs?
A physical therapist is treating a patient on NSAIDs who reports easy bruising and prolonged bleeding after minor injuries. Which of the following mechanisms BEST explains this side effect of NSAIDs?
For a patient with a suspected Achilles tendon issue related to fluoroquinolone use, what is the MOST critical aspect of the physical examination?
For a patient with a suspected Achilles tendon issue related to fluoroquinolone use, what is the MOST critical aspect of the physical examination?
Which of the following pieces of information gathered from Ms. Valhalla's history is MOST indicative of a potential systemic or non-musculoskeletal issue contributing to her shoulder pain?
Which of the following pieces of information gathered from Ms. Valhalla's history is MOST indicative of a potential systemic or non-musculoskeletal issue contributing to her shoulder pain?
What is the PRIMARY reason to limit weight bearing and immobilize the affected limb in the initial management of tendinopathy induced by fluoroquinolones?
What is the PRIMARY reason to limit weight bearing and immobilize the affected limb in the initial management of tendinopathy induced by fluoroquinolones?
A patient diagnosed with osteomalacia is prescribed supplements. Which combination would be MOST appropriate?
A patient diagnosed with osteomalacia is prescribed supplements. Which combination would be MOST appropriate?
Which of the following mechanisms of action is associated with bisphosphonates in the treatment of osteoporosis?
Which of the following mechanisms of action is associated with bisphosphonates in the treatment of osteoporosis?
A patient with Paget's disease is prescribed medication to manage their condition. Besides calcium supplementation, which of the following medications is MOST likely to be included in their treatment plan?
A patient with Paget's disease is prescribed medication to manage their condition. Besides calcium supplementation, which of the following medications is MOST likely to be included in their treatment plan?
Which of the following describes the primary mechanism by which bacteriostatic drugs inhibit bacterial growth?
Which of the following describes the primary mechanism by which bacteriostatic drugs inhibit bacterial growth?
A patient taking penicillin develops signs of CNS dysfunction and anemia. Which aspect of penicillin administration is MOST likely responsible for this?
A patient taking penicillin develops signs of CNS dysfunction and anemia. Which aspect of penicillin administration is MOST likely responsible for this?
Why is it crucial to inquire about a patient’s current medications, especially antibiotics, during a physical therapy evaluation?
Why is it crucial to inquire about a patient’s current medications, especially antibiotics, during a physical therapy evaluation?
A patient taking ciprofloxacin reports Achilles pain and inflammation. Given this information, which of the following modifications to the physical therapy plan of care is MOST appropriate?
A patient taking ciprofloxacin reports Achilles pain and inflammation. Given this information, which of the following modifications to the physical therapy plan of care is MOST appropriate?
A patient with a suspected bacterial infection is prescribed a broad-spectrum antibiotic. What is the PRIMARY advantage of using a broad-spectrum antibiotic compared to a narrow-spectrum one?
A patient with a suspected bacterial infection is prescribed a broad-spectrum antibiotic. What is the PRIMARY advantage of using a broad-spectrum antibiotic compared to a narrow-spectrum one?
A patient presents with diffuse bone pain, muscle weakness, and a history of multiple fractures. Lab results reveal low vitamin D levels and radiographic imaging shows decreased bone density. Which of the following conditions is the MOST likely diagnosis?
A patient presents with diffuse bone pain, muscle weakness, and a history of multiple fractures. Lab results reveal low vitamin D levels and radiographic imaging shows decreased bone density. Which of the following conditions is the MOST likely diagnosis?
A patient with Paget's disease is MOST likely to exhibit which combination of signs and symptoms?
A patient with Paget's disease is MOST likely to exhibit which combination of signs and symptoms?
A physical therapist is treating a patient with osteomalacia. Which of the following interventions is MOST appropriate to address the musculoskeletal implications of this condition?
A physical therapist is treating a patient with osteomalacia. Which of the following interventions is MOST appropriate to address the musculoskeletal implications of this condition?
Why is it MOST important to refer a patient with recurrent arthritic symptoms and a previous diagnosis of gout back to their physician?
Why is it MOST important to refer a patient with recurrent arthritic symptoms and a previous diagnosis of gout back to their physician?
Which of the following signs or symptoms should prompt a physical therapist to immediately refer a patient with diabetes for further medical evaluation?
Which of the following signs or symptoms should prompt a physical therapist to immediately refer a patient with diabetes for further medical evaluation?
A patient presents with acute joint pain, swelling, and redness, accompanied by fever and chills. Which of the following metabolic disorders is MOST likely indicated by these signs and symptoms?
A patient presents with acute joint pain, swelling, and redness, accompanied by fever and chills. Which of the following metabolic disorders is MOST likely indicated by these signs and symptoms?
Which combination of factors would place a patient at the HIGHEST risk for developing osteoporosis?
Which combination of factors would place a patient at the HIGHEST risk for developing osteoporosis?
A patient with suspected osteoporosis reports a gradual loss of height and increased rounding of their upper back. Which of the following is the MOST likely underlying cause?
A patient with suspected osteoporosis reports a gradual loss of height and increased rounding of their upper back. Which of the following is the MOST likely underlying cause?
Which statement BEST describes the primary difference between osteoporosis and osteomalacia?
Which statement BEST describes the primary difference between osteoporosis and osteomalacia?
A physical therapist is reviewing a patient's imaging results for hip osteoarthritis. The radiograph reveals a positive finding for mild osteoarthritis, but the physician wants to evaluate cartilage integrity. Which imaging modality is MOST appropriate in this scenario?
A physical therapist is reviewing a patient's imaging results for hip osteoarthritis. The radiograph reveals a positive finding for mild osteoarthritis, but the physician wants to evaluate cartilage integrity. Which imaging modality is MOST appropriate in this scenario?
A patient is undergoing initial screening for osteoporosis. Which imaging technique is considered the MOST appropriate for assessing bone density in the lumbar spine and hips?
A patient is undergoing initial screening for osteoporosis. Which imaging technique is considered the MOST appropriate for assessing bone density in the lumbar spine and hips?
A patient with known low bone density has several risk factors for osteoporosis progression. Which imaging technique is MOST appropriate for monitoring changes in bone density over time?
A patient with known low bone density has several risk factors for osteoporosis progression. Which imaging technique is MOST appropriate for monitoring changes in bone density over time?
Which of the following additional findings on a radiograph would warrant further investigation into potential metabolic bone disease?
Which of the following additional findings on a radiograph would warrant further investigation into potential metabolic bone disease?
A patient presents with bone pain, muscle weakness, and a history of fractures. Lab results reveal vitamin D deficiency. Which condition is MOST likely?
A patient presents with bone pain, muscle weakness, and a history of fractures. Lab results reveal vitamin D deficiency. Which condition is MOST likely?
A physical therapist is treating a patient with osteomalacia. Which intervention is MOST appropriate given the musculoskeletal implications?
A physical therapist is treating a patient with osteomalacia. Which intervention is MOST appropriate given the musculoskeletal implications?
A patient presents with acute joint pain, swelling, and redness, accompanied by fever and chills. Which of the following conditions is MOST likely indicated by these signs and symptoms?
A patient presents with acute joint pain, swelling, and redness, accompanied by fever and chills. Which of the following conditions is MOST likely indicated by these signs and symptoms?
A patient reports a gradual loss of height and increased rounding of their upper back. Which of the following is the MOST likely underlying cause, assuming osteoporosis is present?
A patient reports a gradual loss of height and increased rounding of their upper back. Which of the following is the MOST likely underlying cause, assuming osteoporosis is present?
A physical therapist is reviewing a patient's imaging results for hip osteoarthritis. The radiograph reveals a positive finding for mild osteoarthritis, but the goal is to determine cartilage integrity. Which imaging modality is MOST appropriate in this scenario?
A physical therapist is reviewing a patient's imaging results for hip osteoarthritis. The radiograph reveals a positive finding for mild osteoarthritis, but the goal is to determine cartilage integrity. Which imaging modality is MOST appropriate in this scenario?
Which cellular adaptation involves an increase in the number of cells in a tissue?
Which cellular adaptation involves an increase in the number of cells in a tissue?
What cellular adaptation is exemplified by the thickening of the endometrium during the menstrual cycle?
What cellular adaptation is exemplified by the thickening of the endometrium during the menstrual cycle?
A chronic smoker's respiratory system undergoes a change where ciliated pseudostratified columnar cells are replaced by stratified squamous epithelial cells. Which type of cellular adaptation does this represent?
A chronic smoker's respiratory system undergoes a change where ciliated pseudostratified columnar cells are replaced by stratified squamous epithelial cells. Which type of cellular adaptation does this represent?
Which cellular adaptation is considered preneoplastic due to altered cell morphology, increased cell number, and loss of histological organization as a result of prolonged sublethal stress?
Which cellular adaptation is considered preneoplastic due to altered cell morphology, increased cell number, and loss of histological organization as a result of prolonged sublethal stress?
In acute inflammation, which type of leukocyte is primarily involved in the initial response to injury?
In acute inflammation, which type of leukocyte is primarily involved in the initial response to injury?
Which of the following is a key characteristic of acute inflammation?
Which of the following is a key characteristic of acute inflammation?
What is a defining feature of chronic inflammation compared to acute inflammation?
What is a defining feature of chronic inflammation compared to acute inflammation?
A patient presents with signs of edema, decreased activity tolerance, and weight loss. Which of the following nutritional deficiencies is MOST likely contributing to these signs and symptoms?
A patient presents with signs of edema, decreased activity tolerance, and weight loss. Which of the following nutritional deficiencies is MOST likely contributing to these signs and symptoms?
Which cells are predominant in chronic inflammation?
Which cells are predominant in chronic inflammation?
Which of the following psychosocial factors may have the GREATEST effect on an individual's tissue adaptation and injury thresholds?
Which of the following psychosocial factors may have the GREATEST effect on an individual's tissue adaptation and injury thresholds?
Following an acute injury, a patient exhibits redness, swelling, and pain. Which of the following underlying mechanisms is the PRIMARY cause of the redness (rubor) observed?
Following an acute injury, a patient exhibits redness, swelling, and pain. Which of the following underlying mechanisms is the PRIMARY cause of the redness (rubor) observed?
A patient presents with swelling (tumor) following an ankle sprain. What is the PRIMARY mechanism contributing to this swelling?
A patient presents with swelling (tumor) following an ankle sprain. What is the PRIMARY mechanism contributing to this swelling?
A patient reports pain in the tissues surrounding a joint after an injury. Pressure on the tissue exacerbates the pain. Which type of pain is the patient MOST likely experiencing?
A patient reports pain in the tissues surrounding a joint after an injury. Pressure on the tissue exacerbates the pain. Which type of pain is the patient MOST likely experiencing?
Which sequence accurately describes the vascular events leading to edema formation during acute inflammation?
Which sequence accurately describes the vascular events leading to edema formation during acute inflammation?
A patient with localized inflammation exhibits increased temperature in the affected area. Which physiological process primarily contributes to this increase in temperature (calor)?
A patient with localized inflammation exhibits increased temperature in the affected area. Which physiological process primarily contributes to this increase in temperature (calor)?
Several days post-injury, a patient reports throbbing pain that seems disproportionate to the minor swelling observed. Which factor is MOST likely contributing to the patient’s heightened pain perception?
Several days post-injury, a patient reports throbbing pain that seems disproportionate to the minor swelling observed. Which factor is MOST likely contributing to the patient’s heightened pain perception?
Which of the following mechanisms primarily contributes to transudate formation?
Which of the following mechanisms primarily contributes to transudate formation?
A patient with left-sided congestive heart failure is likely to develop which type of fluid accumulation as a result of increased hydrostatic pressure?
A patient with left-sided congestive heart failure is likely to develop which type of fluid accumulation as a result of increased hydrostatic pressure?
Which characteristic is MOST indicative of exudate rather than transudate?
Which characteristic is MOST indicative of exudate rather than transudate?
Which of the following is MOST associated with the vasodilation and increased vascular permeability seen in inflammatory exudate?
Which of the following is MOST associated with the vasodilation and increased vascular permeability seen in inflammatory exudate?
A patient presents with a superficial skin wound that is draining a thin, clear, watery fluid. Which type of exudate is MOST likely present?
A patient presents with a superficial skin wound that is draining a thin, clear, watery fluid. Which type of exudate is MOST likely present?
A patient with a deep wound develops an abscess filled with thick, cloudy fluid containing dead cells and leukocytes. This type of exudate is BEST described as:
A patient with a deep wound develops an abscess filled with thick, cloudy fluid containing dead cells and leukocytes. This type of exudate is BEST described as:
Which type of exudate is MOST likely to be found in the nasal passages of a patient experiencing an upper respiratory infection?
Which type of exudate is MOST likely to be found in the nasal passages of a patient experiencing an upper respiratory infection?
Systemic inflammation, referred to as septicemia, is PRIMARILY characterized by:
Systemic inflammation, referred to as septicemia, is PRIMARILY characterized by:
Which type of fracture fixation is LEAST likely to disrupt the medullary blood supply, promoting primary endosteal healing?
Which type of fracture fixation is LEAST likely to disrupt the medullary blood supply, promoting primary endosteal healing?
A fracture treated with a rigidly applied internal fixation device is MOST likely to heal via which mechanism?
A fracture treated with a rigidly applied internal fixation device is MOST likely to heal via which mechanism?
What is the PRIMARY function of the threaded screw holes in locking plates used for fracture fixation?
What is the PRIMARY function of the threaded screw holes in locking plates used for fracture fixation?
Intramedullary nailing provides relative stability but may have rotational and angular instability unless:
Intramedullary nailing provides relative stability but may have rotational and angular instability unless:
Which statement BEST describes the effect of intramedullary nailing on bone healing?
Which statement BEST describes the effect of intramedullary nailing on bone healing?
Compared to splinting or bracing, casting is MORE effective at:
Compared to splinting or bracing, casting is MORE effective at:
Which of the following is the PRIMARY goal of skeletal traction in fracture management?
Which of the following is the PRIMARY goal of skeletal traction in fracture management?
Which of the following statements BEST describes the current role of skeletal traction in fracture management?
Which of the following statements BEST describes the current role of skeletal traction in fracture management?
Why does prolonged immobilization lead to cartilage degeneration in joints?
Why does prolonged immobilization lead to cartilage degeneration in joints?
Following a period of immobilization, how do connective tissues (CTs) typically respond to stress compared to normal tissues?
Following a period of immobilization, how do connective tissues (CTs) typically respond to stress compared to normal tissues?
How does immobilization affect bone density, and what is the underlying mechanism?
How does immobilization affect bone density, and what is the underlying mechanism?
How does immobilization typically affect muscle tissue, and what characterizes this response?
How does immobilization typically affect muscle tissue, and what characterizes this response?
How does the location of a muscle (one-joint vs. two-joint) influence its response to immobilization?
How does the location of a muscle (one-joint vs. two-joint) influence its response to immobilization?
Which type of muscle fibers (Type I or Type IIa) is more susceptible to atrophy during immobilization, and why?
Which type of muscle fibers (Type I or Type IIa) is more susceptible to atrophy during immobilization, and why?
How does injury to the joint capsule primarily contribute to joint instability?
How does injury to the joint capsule primarily contribute to joint instability?
What role do tendons play in joint motion, and what is their primary structural composition?
What role do tendons play in joint motion, and what is their primary structural composition?
What is the PRIMARY reason intra-articular ligaments, like the ACL, often require surgical intervention to heal?
What is the PRIMARY reason intra-articular ligaments, like the ACL, often require surgical intervention to heal?
Why is progressive, controlled loading crucial to ligament healing?
Why is progressive, controlled loading crucial to ligament healing?
What is a potential consequence of improperly managed ligament injuries?
What is a potential consequence of improperly managed ligament injuries?
How does a collagen-coated FiberTape assist in ligament repair, and what is its main impact on rehabilitation protocols?
How does a collagen-coated FiberTape assist in ligament repair, and what is its main impact on rehabilitation protocols?
During the fibroplasia and repair phase of ligament and tendon healing (3-4 weeks), what precaution is MOST crucial?
During the fibroplasia and repair phase of ligament and tendon healing (3-4 weeks), what precaution is MOST crucial?
Why might synovial fluid surrounding an injured intra-articular ligament interfere with healing?
Why might synovial fluid surrounding an injured intra-articular ligament interfere with healing?
When is surgical intervention MOST likely required for ligament injuries?
When is surgical intervention MOST likely required for ligament injuries?
What is the PRIMARY benefit of using FiberTape augmentation in ligament repair regarding postoperative management?
What is the PRIMARY benefit of using FiberTape augmentation in ligament repair regarding postoperative management?
Flashcards
Imaging ABCS
Imaging ABCS
Alignment, Bones, Cartilage, Soft Tissue. A systematic approach to image interpretation.
Ankylosing Spondylitis
Ankylosing Spondylitis
Inflammatory arthritis affecting the spine, causing stiffness and fusion.
Gout & Lifestyle
Gout & Lifestyle
Arthritis caused by uric acid crystal buildup; lifestyle changes (weight loss, hydration, avoid alcohol) are key.
CT vs. X-ray
CT vs. X-ray
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Smoking Impact
Smoking Impact
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Acute Tendon Healing
Acute Tendon Healing
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Subacute Tendon Healing
Subacute Tendon Healing
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Chronic Tendon Healing
Chronic Tendon Healing
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Cast Immobilization & Tendons
Cast Immobilization & Tendons
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Passive Motion & Tendons
Passive Motion & Tendons
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Weakest Tendon Repair
Weakest Tendon Repair
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Intra-articular Ligaments
Intra-articular Ligaments
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Extra-articular Ligaments
Extra-articular Ligaments
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Ischemia
Ischemia
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Bacterial Infection (Cell Injury)
Bacterial Infection (Cell Injury)
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Immune Reactions (Cell Injury)
Immune Reactions (Cell Injury)
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Chemical Factors (Cell Injury)
Chemical Factors (Cell Injury)
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Physical/Mechanical Factors (Cell Injury)
Physical/Mechanical Factors (Cell Injury)
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Nutritional Factors (Cell Injury)
Nutritional Factors (Cell Injury)
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Necrosis
Necrosis
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Apoptosis
Apoptosis
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Density Contrast in Imaging
Density Contrast in Imaging
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Joint Space Width
Joint Space Width
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Radiodensity Order
Radiodensity Order
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Radiodense Appearance
Radiodense Appearance
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Radiolucent Appearance
Radiolucent Appearance
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Fracture Healing Phases
Fracture Healing Phases
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Strain
Strain
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Sprain
Sprain
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LD50
LD50
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NSAIDs: Risks
NSAIDs: Risks
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NSAIDs: Benefits
NSAIDs: Benefits
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Tylenol: Risks
Tylenol: Risks
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Tylenol: Benefits
Tylenol: Benefits
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Osteomyelitis
Osteomyelitis
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Antibiotic Side Effects
Antibiotic Side Effects
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Myositis
Myositis
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Staph Skin Infection Symptoms
Staph Skin Infection Symptoms
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Endocarditis Symptoms
Endocarditis Symptoms
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Toxic Shock Syndrome (TSS)
Toxic Shock Syndrome (TSS)
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Enteral Drug Administration
Enteral Drug Administration
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Pros of Oral Administration
Pros of Oral Administration
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Cons of Oral Administration
Cons of Oral Administration
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Pros of Sublingual Administration
Pros of Sublingual Administration
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Cons of Sublingual Administration
Cons of Sublingual Administration
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Parenteral Drug Administration
Parenteral Drug Administration
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Pros of IV Administration
Pros of IV Administration
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Cons of IV Administration
Cons of IV Administration
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Absorption (Pharmacokinetics)
Absorption (Pharmacokinetics)
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Bioavailability
Bioavailability
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First-Pass Effect
First-Pass Effect
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Therapeutic Index (TI)
Therapeutic Index (TI)
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Non-Opioid Agents: Action
Non-Opioid Agents: Action
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Non-Opioid Agents: Indications
Non-Opioid Agents: Indications
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Non-Opioid Agents: Side Effects
Non-Opioid Agents: Side Effects
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Non-Opioid Agents & PT
Non-Opioid Agents & PT
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Acetaminophen (Tylenol)
Acetaminophen (Tylenol)
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Reye's Syndrome
Reye's Syndrome
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NSAIDs & Prostaglandins
NSAIDs & Prostaglandins
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Cyclooxygenase (COX)
Cyclooxygenase (COX)
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Fluoroquinolone Tendinopathy
Fluoroquinolone Tendinopathy
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Tendon Off-loading
Tendon Off-loading
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Aggravating Factors
Aggravating Factors
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Easing Factors
Easing Factors
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Red/Yellow Flags
Red/Yellow Flags
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Interscapular Pain
Interscapular Pain
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Paresthesia
Paresthesia
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Ms. Valhalla's History
Ms. Valhalla's History
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NSAID Adverse Effects
NSAID Adverse Effects
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Rheumatoid Arthritis (RA)
Rheumatoid Arthritis (RA)
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DMARD Action
DMARD Action
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DMARD Side Effects
DMARD Side Effects
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Glucocorticoid Action
Glucocorticoid Action
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Glucocorticoid Side Effects
Glucocorticoid Side Effects
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Osteoarthritis (OA)
Osteoarthritis (OA)
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Viscosupplementation
Viscosupplementation
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Osteoporosis Treatment
Osteoporosis Treatment
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Bisphosphonates
Bisphosphonates
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Antibacterial Actions
Antibacterial Actions
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Antibacterial Mechanisms
Antibacterial Mechanisms
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Antibacterial Side Effects
Antibacterial Side Effects
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Antibiotic Resistance
Antibiotic Resistance
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Fluoroquinolone Risk
Fluoroquinolone Risk
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Ciproflaxin Achilles Tendon Advice
Ciproflaxin Achilles Tendon Advice
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Osteomalacia
Osteomalacia
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Paget's Disease
Paget's Disease
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Osteomalacia Symptoms
Osteomalacia Symptoms
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Paget's Symptoms
Paget's Symptoms
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Potassium Depletion Signs
Potassium Depletion Signs
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Gout
Gout
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Osteoporosis
Osteoporosis
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Osteoporosis Risk Factors
Osteoporosis Risk Factors
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Osteoporosis S&S
Osteoporosis S&S
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Initial OA Imaging
Initial OA Imaging
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Initial Osteoporosis Screening
Initial Osteoporosis Screening
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Osteomalacia Definition
Osteomalacia Definition
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Paget's Disease Definition
Paget's Disease Definition
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Osteoporosis definition
Osteoporosis definition
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Dowager's Hump
Dowager's Hump
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Osteoporosis Symptoms
Osteoporosis Symptoms
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Osteoporosis Screening
Osteoporosis Screening
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Neuropathy (B12 Deficiency)
Neuropathy (B12 Deficiency)
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Protein Malnutrition
Protein Malnutrition
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Inflammation Clinical Signs
Inflammation Clinical Signs
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Rubor
Rubor
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Calor
Calor
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Tumor (Inflammation)
Tumor (Inflammation)
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Dolor (Inflammation)
Dolor (Inflammation)
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Mechanical Pain (Inflammation)
Mechanical Pain (Inflammation)
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Atrophy
Atrophy
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Hypertrophy
Hypertrophy
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Hyperplasia
Hyperplasia
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Metaplasia
Metaplasia
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Dysplasia
Dysplasia
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Acute Inflammation
Acute Inflammation
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Chronic Inflammation
Chronic Inflammation
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Chronic Inflammation: Vascular Reaction
Chronic Inflammation: Vascular Reaction
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Effusion
Effusion
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Transudate
Transudate
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Exudate
Exudate
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Sanguineous Exudate
Sanguineous Exudate
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Serous Exudate
Serous Exudate
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Serosanguinous Exudate
Serosanguinous Exudate
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Catarrhal Exudate
Catarrhal Exudate
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Purulent Exudate
Purulent Exudate
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Threaded Traction Pins
Threaded Traction Pins
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Circular Fixator
Circular Fixator
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Open Reduction Internal Fixation (ORIF)
Open Reduction Internal Fixation (ORIF)
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Locking Plates
Locking Plates
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Intramedullary Nailing
Intramedullary Nailing
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Splints/Fracture Braces
Splints/Fracture Braces
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Casting
Casting
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Skeletal (Buck’s) Traction
Skeletal (Buck’s) Traction
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Cartilage Degeneration (Immobilization)
Cartilage Degeneration (Immobilization)
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Ligament Weakness (Immobilization)
Ligament Weakness (Immobilization)
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Bone Density Decrease (Immobilization)
Bone Density Decrease (Immobilization)
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Muscle Atrophy (Immobilization)
Muscle Atrophy (Immobilization)
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Ligaments, Capsules, & Tendons Role
Ligaments, Capsules, & Tendons Role
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Ligaments & Joint Capsules Function
Ligaments & Joint Capsules Function
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Tendon Function
Tendon Function
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Joint Capsule Composition
Joint Capsule Composition
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Ligament Contact
Ligament Contact
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Progressive Loading
Progressive Loading
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Ligament Protection
Ligament Protection
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Surgery Decision Factors
Surgery Decision Factors
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ACL Healing
ACL Healing
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MCL Healing
MCL Healing
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FiberTape Benefits
FiberTape Benefits
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Ligament Protection Timeline
Ligament Protection Timeline
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Study Notes
- Cell injury can be reversible or irreversible
- Reversible injuries occur when the cell can restore homeostasis
- Irreversible injuries result in cell death, known as necrosis
- In irreversible cell injury, intracellular proteins denature and autolysis occurs.
- The cell swells, ruptures, and releases lysosomal enzymes.
- Reversible cell injury increases intracellular ions, interstitial fluids merge into the cytosol, cell volume increases, and the cell membrane blebs.
- Ischemia means blood flow is insufficient or absent.
- Causes include circulatory issues, metabolism problems, inadequate respiratory transport, and cardiovascular transport issues.
- Infections can cause cell injury; the most common are bacterial and viral.
- Immune reactions caused by hypersensitivities or autoimmune disorders can also injure cells.
- Bacterial infections can invade the host, triggering an inflammatory response and producing endotoxins and exotoxins
- Endotoxins induce cytokines and systemic symptoms of sepsis
- Exotoxins damage host cells directly.
- Viral infections can be RNA or DNA viruses, affecting cells directly or indirectly.
- RNA viruses disrupt cell integrity
- DNA viruses signal the cell's destruction.
- Chemical factors causing cell injury include carbon monoxide, ammonia, heavy metals, alkylating agents, and free radicals.
- Carbon monoxide and ammonia cause most injuries and death
- Free radicals damage cell membranes and are linked to cancer, atherosclerosis, Alzheimer's, and Parkinson's.
- Physical factors of cell injury will include blunt trauma, temperature extremes, radiation and electricity
- Mechanical factors of physical injury are different from increased stress from exercise
- Nutritional causes example, Vitamin B12 deficiency leads to neuropathy.
- Neuropathy is a general term for injuries that cause nerve death or injury.
- Calcium deficiency leads to poor bone quality
- Protein malnutrition leads to weight loss due to low protein levels.
- Psychosocial factors impact activity level and participation, influencing thresholds for tissue adaptation and injury.
- Inflammation cardinal signs include:
- Redness: Vasodilation increases blood flow due to histamine and prostaglandins.
- Heat: Increased blood flow from the body's core.
- Swelling: Capillary fluid shift mechanism causes protein and water movement.
- Pain: Mechanical pain is caused by swelling and edema pressing on tissues
- Biochemical pain: inflammatory mediators at the site irritate bare nerve endings.
- Necrosis is the endpoint of a pathological process; involves cell death due to injury
- Apoptosis is programmed cell death that does not require triggers
- Adaptations can take place within cells due to injury and can alter their functions
- Adaptation cellular includes:
- Atrophy: reduced organ size
- Bone loss, muscle wasting, brain cell loss
- Hypertrophy: cell organ increases in size such in the tissue
- Increase endometrium
- Hyperplasia: increases cell numbers in the tissue
- Callous when underr mechanical pressure
- Metaplasia: change in cell morphology
- Smoking
- Hypertrophy: cell organ increases in size such in the tissue
- Acute inflammation major components: exudation of fluid and plasma proteins and the migration of leukocytes, primarily neutrophils, to the injury site
- Chronic inflammation major component: inflammation does not resolve, but persists over time
- Vascular reactions in the area where :
- Accumulation is exudation
- General muscle atrophy typically occurs in one-joint muscles, as two-joint muscles are less immobilized by typical immobilization methods
- Immobilization of a joint causes atrophic changes in articular cartilage by reducing matrix proteoglycans and cartilage softening
- Three components: Load deprivation results which - loss in ligament strength - Deterioration in ligament biochemical and mechanical properties - Atrophy (decreas of mass)
- Main key features of joint capsules
- Connect and the joint with ligaments and tendons
- Transmit muscle to bones during jointing motions
- By producing joint motions and ligaments to protect the parallel allignment
- Transmit muscle to bones during jointing motions
- Connect and the joint with ligaments and tendons
- Joint capsules: resists loads innjury </existing_notes>
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