NPB MT2

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Questions and Answers

What role does the direct pathway in the basal ganglia play in movement initiation?

  • It exclusively limits movement initiation to reflex actions.
  • It acts as a neuromodulator reducing synaptic transmission.
  • It inhibits movement through thalamus activation.
  • It facilitates the initiation of voluntary movements. (correct)

Which of the following distinguishes the indirect pathway in the basal ganglia?

  • It boosts the execution of planned movements.
  • It facilitates motor learning through dopamine release.
  • It inhibits initiation of movements. (correct)
  • It has no effect on the thalamus.

How do pluripotent stem cells differ from other cell types?

  • They can only differentiate into brain cells.
  • They specifically generate muscular tissue.
  • They can develop into any cell type in the body. (correct)
  • They are unable to divide indefinitely.

What is the primary function of the Circle of Willis in brain circulation?

<p>To ensure continuous blood supply to the brain. (A)</p> Signup and view all the answers

What are the primary consequences of a hemorrhagic stroke?

<p>Damage from pressure and bleeding in the brain. (C)</p> Signup and view all the answers

What is primarily affected in individuals with right parietal lobe syndrome?

<p>Spatial awareness of the opposite side. (A)</p> Signup and view all the answers

In terms of voluntary vs reflexive movements, which statement is correct?

<p>Voluntary movements depend on the motor cortex. (A)</p> Signup and view all the answers

What characterizes the process of dopamine signaling in the nigro-striatal pathway?

<p>It modulates motor control by influencing movement initiation. (C)</p> Signup and view all the answers

What impact does a lesion in the motor cortex have on voluntary movements?

<p>It leads to weakness or loss of specific movements. (B)</p> Signup and view all the answers

Which spinal cord injury is associated with the highest level of paralysis?

<p>Tetraplegia. (A)</p> Signup and view all the answers

Which option identifies the location of cell bodies responsible for transmitting sensory information from the body to the brain?

<p>Dorsal root ganglion (A)</p> Signup and view all the answers

Which plane would separate the body into anterior and posterior portions?

<p>Coronal (B)</p> Signup and view all the answers

What type of paralysis is associated with lower motor neuron injury?

<p>Flaccid paralysis (C)</p> Signup and view all the answers

Which statement about aneurysms and 'ballooning' is accurate?

<p>An aneurysm is an abnormal widening of an artery; ballooning can cause bleeding into or around the brain (C)</p> Signup and view all the answers

How does medication that selectively activates D2 receptors in the basal ganglia affect the balance between the direct and indirect pathways?

<p>Inhibits the indirect pathway; relieves rigidity (A)</p> Signup and view all the answers

What would be the likely symptom for a person with a lesion at the C5 level?

<p>Loss of touch on the side ipsilateral to the lesion (B)</p> Signup and view all the answers

How do the basal ganglia influence motor behavior?

<p>By interacting with various pathways including the cortical outputs (C)</p> Signup and view all the answers

Where would you expect to find dye a few days after injecting an anterograde tracer into the left motor cortex, specifically in the hand area?

<p>In the spinal nerve that innervates the right hand (C)</p> Signup and view all the answers

What is the best therapeutic approach for managing Parkinson's disease symptoms by increasing dopamine levels?

<p>L-DOPA medication (B)</p> Signup and view all the answers

Which pathway describes the motor information pathway for pinching fingers together to retrieve hair?

<p>Left Motor cortex -&gt; Right Corticospinal tract -&gt; Right Ventral horn (C)</p> Signup and view all the answers

If you selectively activate the indirect pathway of the basal ganglia, what would be the expected effect on movement control?

<p>Increased inhibition of movement (A)</p> Signup and view all the answers

Which brain region is correctly paired with its primary function in voluntary motor control?

<p>Basal ganglia; movement coordination, planning/prediction (A)</p> Signup and view all the answers

Which option accurately describes the pathway of motor information for movement initiation?

<p>Left Motor cortex -&gt; Right Corticospinal tract -&gt; Right Ventral horn (B)</p> Signup and view all the answers

What would be the result of activating the indirect pathway of the basal ganglia?

<p>Increased inhibition of movement (D)</p> Signup and view all the answers

Which pairing of a brain region and its function related to voluntary motor control is correct?

<p>Basal ganglia; movement coordination, planning/prediction (C)</p> Signup and view all the answers

Which structure's cell bodies are responsible for transmitting sensory information to the brain?

<p>Dorsal root ganglion (C)</p> Signup and view all the answers

A cut along which plane would divide the body into anterior and posterior sections?

<p>Coronal (A)</p> Signup and view all the answers

What type of paralysis is caused by lower motor neuron injury?

<p>Flaccid paralysis (B)</p> Signup and view all the answers

Which statement about aneurysms and their associated symptoms is accurate?

<p>An aneurysm is an abnormal widening of an artery; ballooning can cause bleeding into or around the brain (C)</p> Signup and view all the answers

How would medication that selectively activates D2 receptors in the basal ganglia affect motor control pathways?

<p>Inhibits the indirect pathway; relieves rigidity (B)</p> Signup and view all the answers

What does hemispatial neglect refer to?

<p>No conscious awareness of the opposite side of the world (D)</p> Signup and view all the answers

Which of the following statements about arteries is correct?

<p>Arteries carry oxygenated blood away from the heart (D)</p> Signup and view all the answers

What type of movement do upper motor neurons control?

<p>Voluntary movements (B)</p> Signup and view all the answers

What is the primary function of the diaphragm?

<p>To facilitate breathing (C)</p> Signup and view all the answers

What does the term 'contralateral' refer to?

<p>Opposite side of the body (C)</p> Signup and view all the answers

How are voluntary movements characterized?

<p>They are purposeful and initiated in response to stimuli (B)</p> Signup and view all the answers

What is the role of the corticospinal tract located in the nervous system?

<p>To enable voluntary movement on the ipsilateral side (C)</p> Signup and view all the answers

What differentiates reflexes from voluntary movements?

<p>Reflexes are rapid and involuntary responses (B)</p> Signup and view all the answers

Which condition is characterized by a collection of blood underneath the dura?

<p>Subdural hematoma (C)</p> Signup and view all the answers

What typically causes a spinal bifida defect?

<p>Improper formation of vertebrae (C)</p> Signup and view all the answers

What is primarily affected in Parkinson's disease?

<p>Movement control (D)</p> Signup and view all the answers

Which method is NOT typically used to manage symptoms of Parkinson's disease?

<p>Antiepileptic medications (A)</p> Signup and view all the answers

What describes the result of a coup-contrecoup injury?

<p>Collision of brain tissue with the skull (A)</p> Signup and view all the answers

What is the primary pathway through which the basal ganglia influence motor behavior?

<p>Corticospinal tract (C)</p> Signup and view all the answers

Which movement would be classified as a fine motor movement?

<p>Pinching fingers together (C)</p> Signup and view all the answers

Which of the following is a potential result of polio?

<p>Flaccid paralysis (D)</p> Signup and view all the answers

Flashcards

Hemispatial Neglect

A condition where a person is unaware of the opposite side of their body or the world. They might only eat from one side of their plate or draw only half a picture.

Circle of Willis

A network of arteries at the base of the brain that connects major arteries to ensure continuous blood flow.

Arteries vs. Veins

Arteries carry oxygenated blood away from the heart. Veins carry deoxygenated blood back to the heart. The exception is the pulmonary artery (deoxygenated) and pulmonary vein (oxygenated).

Unilateral vs. Bilateral

Unilateral refers to one side of the body. Bilateral refers to both sides of the body.

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Ipsilateral vs. Contralateral

Ipsilateral refers to the same side of the body. Contralateral refers to the opposite side of the body.

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Dermatome

A specific region of skin that is innervated by a single spinal nerve.

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Upper Motor Neuron

A neuron located in the brain that sends signals for voluntary movement to the spinal cord.

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Lower Motor Neuron

A neuron located in the spinal cord that receives signals from the brain and directly controls muscle contractions.

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Direct Pathway

A neural pathway that facilitates movement initiation by directly stimulating the thalamus.

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Indirect Pathway

A neural pathway that inhibits movement initiation by indirectly suppressing the thalamus through the substantia nigra.

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What is the function of the Cerebellum?

The cerebellum is responsible for refining and coordinating movements, ensuring smooth and precise motor control. It receives sensory input and helps adjust motor commands.

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What is the Basal Ganglia's role in movement?

The Basal Ganglia initiates and regulates movement, helping to select and initiate appropriate motor programs. It plays a crucial role in planning and executing voluntary actions.

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What is Dopamine's significance in the Basal Ganglia?

Dopamine acts as a neuromodulator in the Basal Ganglia, contributing to smooth and balanced movement. It facilitates the 'go' pathway and suppresses the 'no go' pathway.

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What is a Stroke?

A stroke occurs when a blood vessel in the brain is blocked or ruptured, leading to a disruption in blood flow. This causes damage to brain tissue and loss of neurological function.

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What are the types of Strokes?

There are two main types of strokes: Ischemic stroke, caused by a blocked blood vessel, and Hemorrhagic stroke, caused by a ruptured blood vessel.

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What is Hemispatial Neglect?

Hemispatial Neglect is a neurological disorder characterized by an inability to attend to or perceive stimuli on one side of space, typically the left side after a right-sided brain injury.

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What is Prosopagnosia?

Prosopagnosia is a neurological disorder characterized by an inability to recognize faces, despite otherwise normal visual perception.

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What is the role of the Spinal Cord?

The spinal cord, a long cylindrical bundle of nerve tissue, carries signals between the brain and the rest of the body. It controls basic reflexes, posture, and movement.

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Epidural Hematoma

Bleeding between the skull and the dura mater, usually caused by a ruptured artery.

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Subdural Hematoma

A collection of blood underneath the dura mater, in the subdural space.

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Coup-Contrecoup Injury

Brain injury that occurs when the brain collides with the skull on impact and then rebounds to collide on the opposite side.

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Herniated Disc

A condition where the soft, inner part (nucleus pulposus) of an intervertebral disc protrudes through the tougher outer layer (annulus fibrosus).

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Spinal Bifida

A birth defect that occurs when the vertebrae do not form properly around the spinal cord, resulting in a gap in the spine.

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Meningitis

Inflammation or swelling of the meninges (dura mater, arachnoid mater, and pia mater) that cover the brain and spinal cord.

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Flaccid Paralysis

A type of paralysis characterized by muscle weakness and loss of muscle tone. It is caused by lower motor neuron injury.

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Spastic/Rigid Paralysis

A type of paralysis characterized by muscle stiffness and involuntary spasms. It is caused by upper motor neuron injury.

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Motor Information Pathway

The route motor signals take from the brain to control movement; involves the motor cortex, corticospinal tract, and ventral horn.

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Indirect Pathway of Basal Ganglia

A pathway in the basal ganglia that inhibits movement; helps prevent unwanted movements and maintain smooth control.

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Basal Ganglia Function

The basal ganglia is involved in movement coordination, planning, and prediction. It acts like a conductor for smooth movement.

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Sensory Information Pathway

The pathway that carries sensory information from the body to the brain. It involves the dorsal root ganglion and the spinal cord.

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Anatomical Plane: Coronal

A plane that divides the body into anterior and posterior (front and back) sections.

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Aneurysm and Ballooning

An aneurysm is a bulge or weakening in an artery wall. The ballooning can cause bleeding into or around the brain.

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D2 Receptor Activation

Activation of D2 receptors in the basal ganglia can inhibit the indirect pathway, potentially relieving rigidity and improving movement.

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Dorsal Root Ganglion

A cluster of nerve cell bodies located outside the spinal cord, responsible for transmitting sensory information from the body to the brain. It is involved in touch, temperature, pain, and proprioception.

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Lower Motor Neuron Injury

Damage to the nerve cells that directly control muscle movement, resulting in flaccid paralysis, characterized by muscle weakness, reduced reflexes, and decreased muscle tone.

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Aneurysm

An abnormal, localized widening or ballooning of an artery wall, which can weaken the vessel and lead to rupture, causing bleeding into or around the brain.

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Direct vs. Indirect Pathways

Two interconnected pathways in the Basal Ganglia: The Direct Pathway promotes movement by activating the thalamus, while the Indirect Pathway inhibits movement by suppressing the thalamus.

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Lesion at C5: Symptoms

A lesion at C5 would result in the loss of sensation and voluntary movement below the level of the lesion, with more severe effects on the ipsilateral side.

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Anterograde Tracing

Anterograde tracing involves injecting a dye into a specific neuron to track its axon's path and identify its target areas.

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Parkinson's Treatment

L-DOPA medication is commonly used to manage Parkinson's symptoms by providing a precursor to dopamine, which is deficient in the disease.

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Fine Motor Movement Pathway

The pathway for fine motor movements involves the motor cortex initiating the signal, which travels down the corticospinal tract to the ventral horn of the spinal cord, ultimately reaching the muscles.

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Indirect Pathway Function

The indirect pathway of the basal ganglia inhibits movement initiation by suppressing the thalamus, preventing unwanted movements.

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Brain Region & Function

The basal ganglia is critically involved in movement coordination, planning, and prediction.

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Cerebellum Function

The cerebellum is responsible for fine-tuning movements, making them smooth and coordinated.

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Study Notes

Midterm 2 Study Guide

  • This is a review guide for sections L8-L11, not an exhaustive list.
  • Items not listed may still be important.

Definitions

  • Hemispatial neglect (hemineglect): Lack of conscious awareness of the opposite side of the world or oneself.
  • Circle of Willis: Network of arteries at the base of the brain.
  • Arteries: Carry oxygenated blood away from the heart (except pulmonary artery).
  • Veins: Carry deoxygenated blood towards the heart (except pulmonary vein).
  • Unilateral: One side.
  • Bilateral: Two sides.
  • Ipsilateral: Same side.
  • Contralateral: Opposite side.
  • Dermatome: Area of skin innervated by a single spinal nerve.
  • Diaphragm: Main breathing muscle innervated by C3-C5 (phrenic nerve).
  • Upper motor neurons: Brain neurons sending signals to the spinal cord for voluntary movement.
  • Lower motor neurons: Spinal cord neurons extending to skeletal muscles.
  • Ganglion: Collection of neuron cell bodies outside the brain/spinal cord (e.g., basal ganglia are inside).

Key Topics/Concepts

  • Brain damage: Consequences of damage to different brain regions (frontal, temporal, brainstem, cerebellum, occipital, and parietal lobes).
  • Brain circulation: Importance of brain vasculature, flow of oxygenated and deoxygenated blood, and the circle of Willis.
  • Strokes: Types of strokes (ischemic, hemorrhagic), consequences of strokes.
  • Brain anatomy: Spaces and meninges of the brain, methods of viewing brain structure (anatomical planes/sections- sagittal, coronal, transverse).
  • Spinal cord: Details of spinal injuries and relationships between spinal cord, vertebral column, and the spinal nerves.
  • Brain-spinal relationships: Information flow and the spinal cord (efferent/afferent signals, reflex arc, spinal tracts).
  • Voluntary vs reflexive movements: Relevant brain structures and their roles in voluntary movement, and which pathways are associated with voluntary vs reflexive movements.
  • Motor control: Key concepts of motor control and the role of descending motor pathways and basal ganglia.
  • Reflexes: Simple, involuntary responses.
  • Postural reflexes: Maintain body posture and balance.

Additional Topics

  • Voluntary Movements: Purposeful, goal-directed actions.
  • Neuromodulators: Neurotransmitters that modulate neural activity without opening ion channels.
  • Pluripotent Stem Cells: Can divide indefinitely and develop into any cell type.
  • Consequences of brain damage: Focal vs diffuse damage, specific symptoms from lesions (e.g., loss of voluntary movement, loss of sensation, cognitive deficits).
  • Types of strokes: Hemorrhagic, ischemic (thrombotic, embolic). Effects of stroke on brain function and recovery.
  • Spinal cord injuries: Types of spinal cord injuries (e.g., compression). Consequences and symptoms.
  • Brain regions involved in Voluntary movement control: Motor cortex, basal ganglia, and cerebellum. Their roles and interconnections are important.
  • Consequences of lesions: Location of lesion and its impact on the body.
  • Neuroplasticity: Ability of the brain to change and adapt over time with new experiences.

Glossary

  • Brain Structures: Specific regions (frontal, temporal..)
  • Neural Pathways: (e.g., corticospinal, indirect...)
  • Neurotransmitters: (e.g., Dopamine, GABA..)
  • Reflexes: (e.g., withdrawal..)
  • Treatments: (e.g, deep brain stimulation)

Test Your Knowledge

Numerous questions are included to test understanding and reinforce concepts learned in the course. Questions involving specific clinical scenarios are also covered.

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