NPB MT3
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Questions and Answers

What type of amnesia is characterized by the inability to remember events that occurred before an amnesic event?

  • Retrograde amnesia (correct)
  • Anterograde amnesia
  • Transience amnesia
  • Dissociative amnesia

What neurotransmitter is primarily associated with the reward pathway?

  • Dopamine (correct)
  • Acetylcholine
  • Serotonin
  • Norepinephrine

What is the primary characteristic of Alzheimer's disease?

  • Progressive cognitive decline (correct)
  • Recurring hallucinations
  • Rapid, temporary memory loss
  • Sudden mood alterations

Which structure is NOT part of the reward pathway?

<p>Spinothalamic tract (C)</p> Signup and view all the answers

What term describes the body’s diminished response to a substance after its repeated use?

<p>Tolerance (B)</p> Signup and view all the answers

Which of the following statements about opiates is accurate?

<p>They inhibit pain signal transmission (B)</p> Signup and view all the answers

What is the primary action of endorphins in the nervous system?

<p>Activating opioid receptors (B)</p> Signup and view all the answers

What distinguishes schizophrenia from other mental disorders?

<p>Episodes of distorted reality (B)</p> Signup and view all the answers

What is the effect of morphine on the activity of the red neuron?

<p>It decreases (A)</p> Signup and view all the answers

How does the activity of the blue neuron change in the presence of morphine?

<p>It increases due to disinhibition (B)</p> Signup and view all the answers

What will happen to the release of dopamine from the blue neuron when morphine is present?

<p>It will increase due to disinhibition (A)</p> Signup and view all the answers

What is the expected consequence for the activity of the green neuron in response to morphine's effects?

<p>It will increase due to dopamine's excitatory effect (C)</p> Signup and view all the answers

Which of the following is a neurodegenerative disorder?

<p>Alzheimer's disease (D)</p> Signup and view all the answers

Which of the following structures is primarily involved in the reward pathway?

<p>Nucleus accumbens (B)</p> Signup and view all the answers

Which mechanism describes how opioids inhibit neuronal activity?

<p>They act on presynaptic inhibitory mechanisms (C)</p> Signup and view all the answers

What is NOT a function of the hippocampus?

<p>Regulation of emotions (B)</p> Signup and view all the answers

What primarily affects dopamine levels during drug use?

<p>Increased release due to drugs of abuse (D)</p> Signup and view all the answers

What characterizes Tardive dyskinesia in schizophrenia treatment?

<p>It involves involuntary movements. (C)</p> Signup and view all the answers

Which receptors do opioids primarily act upon in the pain pathway?

<p>Opioid receptors (B)</p> Signup and view all the answers

Which type of memory is primarily affected in anterograde amnesia?

<p>Formation of new memories (A)</p> Signup and view all the answers

What is a common factor associated with the development of Alzheimer's disease?

<p>Presence of amyloid plaques (D)</p> Signup and view all the answers

How do dopamine levels change in the reward system during drug use?

<p>They increase rapidly. (A)</p> Signup and view all the answers

Which of the following statements is TRUE regarding opioid receptors?

<p>They play a role in pain modulation. (D)</p> Signup and view all the answers

Which of the following is a known symptom of schizophrenia?

<p>Hallucinations (D)</p> Signup and view all the answers

Flashcards

Retrograde Amnesia

Inability to recall memories formed before an event that caused amnesia.

Anterograde Amnesia

Inability to create new memories after an event that caused amnesia.

Alzheimer's Disease

A progressive brain disorder causing memory loss, thinking difficulties, and behavioral changes.

Reward Pathway

Brain circuit involving dopamine that motivates behavior and processes pleasure.

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Opiates

Drugs derived from the opium poppy that reduce pain by binding to opioid receptors in the nervous system.

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Tolerance

Decreased response to a drug with repeated use as the body adapts.

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Withdrawal

Unpleasant physical and psychological symptoms experienced when stopping a drug after tolerance has developed.

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Schizophrenia

A mental disorder causing distorted reality, hallucinations, thought disorders, and behavioral changes.

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Addiction

A chronic, relapsing brain disease characterized by compulsive drug seeking and use, despite harmful consequences.

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Dopamine

A neurotransmitter that plays a crucial role in the reward pathway. Drugs of abuse increase dopamine levels, leading to feelings of pleasure and reinforcing drug-seeking behavior.

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Cocaine

A stimulant drug that blocks dopamine reuptake, increasing dopamine levels in the synapse and producing intense feelings of euphoria.

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Antipsychotic Drugs

Medications primarily used to treat schizophrenia. They work by blocking dopamine receptors in the brain.

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Amyloid Plaques

Abnormal protein deposits that accumulate in the brain of Alzheimer's patients and contribute to neuronal damage.

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Opioids and Neuronal Activity

Opioids, like morphine, decrease the activity of neurons by binding to opioid receptors. This effect reduces the release of neurotransmitters.

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Disinhibition

When a neuron that normally inhibits another neuron is suppressed, the inhibited neuron becomes more active. This is called disinhibition.

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Dopamine Release

The release of dopamine, a neurotransmitter associated with reward and pleasure, is increased when a neuron is disinhibited and more active.

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D1 Receptors

D1 receptors are a type of dopamine receptor that are stimulated by dopamine, leading to an excitatory effect on the neuron.

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Neurodegenerative Disorders

Neurodegenerative disorders are characterized by the progressive degeneration and death of nerve cells in the brain, leading to functional decline.

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Hippocampus

The hippocampus is a brain region involved in learning, memory, and spatial navigation. It is located in the temporal lobe.

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Glutamate Receptor Antagonists

Glutamate receptor antagonists block the action of glutamate, an excitatory neurotransmitter. They are used in Alzheimer's disease to manage the symptoms.

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Acetylcholinesterase Inhibitors

Acetylcholinesterase inhibitors increase the levels of acetylcholine, a neurotransmitter involved in learning and memory, in the brain. They are used in Alzheimer's disease to improve cognitive function.

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Study Notes

Definitions

  • Retrograde amnesia: Inability to remember events before the incident causing amnesia.
  • Anterograde amnesia: Inability to form memories after the incident causing amnesia.
  • Alzheimer's disease: Irreversible brain disorder progressively destroying memory and cognitive abilities.
  • Reward pathway: Brain circuit (VTA→Nucleus Accumbens/ventral striatum→ Prefrontal cortex) responsible for processing survival-related stimuli using dopamine. Different from the substantia nigra/striatum pathway involved in movement regulation.
  • Opiates: Natural products from opium poppies binding to opioid receptors, inhibiting pain signals.
  • Spinothalamic tract: Axons conveying pain information from the contralateral side of the body.
  • Endorphins: Body's natural opioids activating opioid receptors for pain relief.
  • Tolerance: A decreased response to a drug after repeated use as the body adapts.
  • Withdrawal: Physiological disturbance from abruptly stopping a drug after tolerance development.
  • Schizophrenia: Mental disorder marked by episodes of unreal experiences and distorted perceptions.
  • Addiction: A state of dependence leading to repeated compulsive use.

Key Topics/Concepts

  • Addiction: Includes types and sources of addiction, and the reward pathway.
  • Alzheimer's disease: Includes causes and symptoms (dementia).
  • Drugs of abuse: Mechanisms of action on the reward pathway and dopamine levels.
  • Schizophrenia: Factors linked to the condition and symptoms associated with it.

Neurotransmitters and Receptors

  • Dopamine: A key neurotransmitter in the reward pathway, involved in motivated behavior.
  • GABA: Inhibits neuronal activity (important in pain pathways).
  • Opioid receptors: Act as targets for opiates and endorphins to moderate pain.
  • D1 receptors: Excitatory receptors for dopamine having a positive effect on their activity.

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Related Documents

Midterm 3 Exam Prep PDF

Description

Test your knowledge on critical concepts in neuroscience including types of amnesia, the role of the reward pathway, and the effects of opiates. This quiz covers key terms and definitions relevant to cognitive functions and pain mechanisms in the brain.

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