Pharmacology 1 Notes PDF - B Pharmacy 4th Sem

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l l l el el Page 1 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar C C a a rm rm ha ha ha OWnd lP lP lP el el Phara Pharma ew ew not ar ar C tor C (AHAel TUst Tust TUS a a rm rm ha ha ha Is holb lP lP lP el el ew ew Note -If You have any Doubts ar ar in any thing in pdf C C Just Ask us in comment of any video, Or confirm it from google This Notes is Provided by Chandan MOCP a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 2 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar Anit-1V C C harmacolbgyo dugs acting n centa Nevous Mtem a a rm rm a Suli ha ha ha Neurohumoval ransmission in the CNS lP lP lP proce 35 Occuy in velotion to to nerve Four el el ew ew transmision wirlin the CNS ar ar process ediated rough affarent C C rons mitters. hese are as o1laws Nonot ronomission OGCuYS throuanineusotansmitters, phic oYe seledsedin toSyoptie eleft:t a a rm rm Topidy stunulate or)"inhibit he post simoptic ha ha ha Meurons s lP lP lP DJleuso- modulatioy neuromodulators, el el OCcuis through ew ew by TOhish ara ture leased by reuions and ar ar CstrocutesOndact crlher torsloud Co) Cnhance C C pTe OT) post synaptic TEsporsasS 3 /Naromeiatin OCCuYS through neuomediotos, which a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 3 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar messenges cAMP cGnMP are Sicond C C T iy Neuroheric affecs occurthrouho nerotrepie orbrs which Secteted astvoctes by ncurcnS a a rm rm onger ime to MiCIOglia ondactactovNCr ha ha ha requlate he qrowth ond morpelogy otmeurots lP lP lP -AVomeof{he major neuotransmittaxs ro el el ew ew GABA ar ar GABA (Cqammo -Amindbutyric acid) is a major C C - inhbitory neuTotronsmitter in mamma lion CAS:07 -9ti presentt fairly wriHormly n he bin Neiyittlegvamount asists inns, thepcriphery a a J rm rm from GaA GABABA Synthesized glurtamate by het ha ha ha L-glutomic acid- decaybozylase action of Cnzume lP lP lP (CnAD) el el ew ew by taniaminas - 31 1 turthe metabolised aA BA ar ar 5% CnA8A-T) t Succinic semi-aldehydei and C C Succinic acid a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 4 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar uhesis ABA g o C C t lutomine lutominase. ylutomate e 7 a a rm rm Slutomale decatboxylase ha ha ha GABA lP lP lP el el Medanlo CaABA ew ew CaABA ar ar GABA-T eal C C Succinict Semialdehyde Succinie Senialdehyee i a a dehydiogelase p31 rm rm Succinate ha ha ha Siisq) ST Teceptoss of GABA lP lP lP Uerc are 2 types el el ew ew i GABAg ar ar C C CoaBAA eceptoss nS -hese ionotvopic Jeceptois are and are hey CaTC Socated pst-ynapttally a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 5 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar mke ith chloide ion channeorennghel C C the Tedueton he in huperpolosisaton din Causes membrane excitabihhy -he Teceptoyin he a a major sofom otGaA8A rm rm brain Consists o sub units namely "2a ha ha ha units lP lP lP two Sub, el el i seABAs ece ptoS inc ew ew -4t is a protein Ccupled veceptor ar ar -43 C C activatio decreasesfoymation of cAMP yese TCceptos Cause pre ost- sunapte inhibition.by inhibring calcium channel opening t a a and iieasngK Conductance rm rm -Ahe antaqonist tos ha ha ha Competitive CaABAg Teceptor lP lP lP s Sacloten, which has clinicaluse 1 el el lutamate ew ew y synthe siaed -In brain glutamate is the ar ar in C C neTve temmalsrom 2 SouiceS Cycle ) rem qlucose via Krebs Cycle and tran sanin- ation of 01aglutararte a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 6 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar qlulomineohich iakesaed in ghial qhial C C cells hutamate isstored in Sunaptic vesicles Teleased calcium dependent Caocytosi. a a rm rm action Glutomate Tolcase After onMd ha ha ha Tacapturedby neurona GaLo- transporieis (Th) lP lP lP ond type transport neunon bial el el tothe ew ew C15 (OT)into6 he qlial cellss ar ar qlutamote hen covested te qlutamin Aial C C enzyme qlulanine Synthetase Athe Lates qlutomine enters he adjaccntneuron alter hdrolygsiy a a eplenish he qlutomivne rm rm mitochondrial qlutamase ha ha ha upes of qlulamate réceptors lP lP lP five different el el been identked kve ew ew dre (NMDA,AMPA f. OUt of these ive types, 3 ar ar Taceptors C C Kanate) ase ionotropic meta botropic receptors other two Teceptors is being Role of metabotropic a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 7 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar umfalded reseamch b s C C NMDA Yaceptois " - NMDA Tefe to N-melhy asportote -Ihe a a are onqe Yeceptors invoved in a de rm rm of dive1se tunctions ke ike memory OCquisiton, ha ha ha h lP lP lP develment fynapthcPlarticity9RIf el el neuronalCeitotoxicity due tcevebral ischaemia ew ew -t has atleast. binding modulato sites site ar ar C C AMPA kaiateoceptors AmpA Nto - 1etersto -0mino 3-hydroxuTmethylisoan.oe- Popionie, acid a a - Both rm rm AMPA and kainate Teceptors mediate ha ha ha fast Cicitatoru4 sunaptic tronsmision associated lP lP lP with.intux ofodium ons through 3odium el el ew ew channels ar ar -AMPA ieceptors Consisting ot GLDR 1-4 Sub unr C C - kaiate eceplors Conslst ot CnLDRs-1 F KHL Sub unrb: ti a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 8 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar cine C C neuo-tonomtter Cnichedin L4 s an inhibjtory CO1d medulla, spinal heJouwer braim stem f a a rm rm Huactonally siilar to 44 sucturalyp ha ha ha to chioid dinectly iked lP lP lP CrABA Teceptor and el el jon chamc ew ew Aunthesis ar ar C C utamic acid Hutamie acid sbn decaybosyase (aAo) t yav ii +onirohtyic aid (on6A) cot a a rm rm iA H ha ha ha 4ycine lP lP lP ,E el el Release ciok tosis Ca k ho} slef ew ew erotonin(5-hydtoxytytoineSH) sa ar ar inCNS , C C a neutotronsmitter as 4t is TCqu lotor ot Smooth Muscle tunctan o in Ond GIT onaaisvequlotor of platalet a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 9 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar tunc ton C C Aunthesis , ufiti. Sryplophad a a tryrtophanydhonylase rm rm Syehoxy nptophun.. ha ha ha lP lP lP decarbo xulase i el el 5- hydro typtorine (sesotorin) ew ew i 1ts ar ar HT s stored in specia ised celb 7ke C C cntesochomaf tin cells ncuyors as Co-transmtter toqetheruk"oith, Various eptide homones ke like Somatostatin Vasoactivei intestinal peptide (vIP). a a rm rm of S-HT through - Daqra dation oCCuIS Throuqh oxidative ha ha ha deamination by MAO to s kydioxy indole lP lP lP acetaldehyda plowed soidation to s-hydroxu el el ew ew acette indole bcid, ohick"|i3 CIeted iv 'urine ar ar Rhomacoloqialactos io C C CNS - Teqvlationotofmood, ehavipu, sleep -thesmoregulation a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 10 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar C C Conttac tan of vasculay moothmuscle , CIcept in hear? skeletol SAMule a a rm rm shimalates Pei talsi5,ih ha ha ha acid Pepsin tg: lP lP lP opamine 04 el el ew ew mast importont of the bioqenic the :1.' ar ar CNS neurotransmitters h C C disease ii characterised by a masked arkinisos Teduction the Concentra tion ot DA in basal okile in schizophyenia theie is dopaminer a a qongia rm rm overactivit inthe pathuway of brain ohidh ha ha ha (: il sesht. lP lP lP Controls behaviour el el primarily on inhib itony neurotransmitter ew ew Tetypes ot DA Teceptorshavc becn identhed ar ar C C OAMong them OF DD belonq One , D D Dui belong to 0they group a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 11 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar nhesig C C urosina tyrosine udroylase a a L-Copd rm rm Dopa decarboiykse ha ha ha lP lP lP Doponne el el Dopaineis token up n Ho the vesicles by ew ew vesicula manoonino (VMAT ar ar tranbporter C C Teleascd by Ctocu tosi Reuptake n to presunaptie teimial via VMAT ORT PMAT. a a 1 s rm rm enerdl Anacsthetic ha ha ha which yeneral Anaestheties (As) re drugs lP lP lP loss 0t all Sensaion and PTOduce TCveisible el el ew ew Cons ciouSneSS ar ar ttatwes of qencsal anaesthesia he cardinal C C Iass otall scsaton, especally a amne sid yleep a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 12 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar sclozaton ai) gmmobilt g. muscle 1 C C iV AH ton of Sontatic and autoMomic" Tefleres dnaasthe sia Mechanionof reral not Ahe mechanismot at tion ot GA is a a rm rm precisely kholbn ha ha ha tven thei lP lP lP 4nhalaton anaesthetics are non-sclec el el 3 dt tion ew ew A molecular Jcvel, ongesthetics inteact wi ar ar hdiophobice membrane protein otneu1ona C C YCgions ohichare oon interlace oith membrane Jipids Snhaled. anaeshetcs ike like and Prpo-otacihate barbiturates,, benodioaepir a a GnABA es,domidate rm rm meaiated hibiton and heie incTease chlorid ha ha ha lP lP channek lP on 4u. through its el el otlurtamate on ketamineblockshe action ew ew NMOAeceptor ar ar C C isousan iiuan dnhalaton 'anaesthe ticslikertlurneand of icotne decicasesw dutaton fot oeing eceyor activate 30dium on channels leading a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 13 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar to decease iex titatory effects ofi Ach at C C cholinerqic 3ynapse3 By intluencinqi neuromal mannbjane protensgenerol Sensor tiringandSen a a anaesthetic disrupt neuronal rm rm prOce3smg he tholamuls Cousinq lass of ha ha ha analqe etHects: lP lP lP ConsCjousnES and becouse el el Sn addition, motor ot tivity Te dice ew ew the decrtu neuronal ouputroml the ivtemo ar ar C C covte Pimidalaer Midmal alveolar Concentration (MAC) -9 e Xowest coMcentrationof the8hWG! o a a pulmonary clveoli nieed anaestheticin rm rm produce immobilit i eponse. I to a paintul ha ha ha lP lP lP Stimulus in So1 inidviduals el el acceptedasa validmeajure9 ew ew inhalationa potency of fls becausenr it remains ar ar Constaitt mastuoung dults: C C MA he MACof allinhalational onaesthetics ' decines proqTessively as ageadvdnces beiond a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 14 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar So yeais 1 C C toge 3 of Anaesthe sia neguadly descendm depression aAscause of Ake 4he CNS ,1 e he igner tuctios are aut a a rm rm proqiesjively areas f Ahe ha ha ha brain are hvdvedbut in he sphnal cord lP lP lP oiwe 3tqments are affecte 3omeuwhat el el he hiqhetsegments thn, ew ew corlhe ar ar tferatstaaes f anacsthesia are C C tage togeofaielgeia Atarts rom beqininnina ofanaesthehc inhalotion audlasts upto the sof consciousne.s3 a a rm rm s iS prooesively abolshed ha ha ha heat hear and see otetTemina Coscious,Can lP lP lP develops Hee18adirom ikestateamnesia el el ew ew the NIDA end of thisstage ar ar Kelleses and rspiration TCmain notnia C C ge tage of dc lirium rom oss of onsCiousnes tobeqinning o veqular 4 a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 15 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar TESpNanoM :1 C C ma sheut s Seen, patlen 3hou Agparent extitement and hold is brealh ete Struggle -tet sate ond 8P, ma may fse and puils uts a a rm rm dilate due to ymparthe tic stmulation ha ha ha tage ugical anaeslhesig lP lP lP -éxtends trom onsct of ot Yeular Cspira tionto el el ous, breathng ew ew CcSSaton of Spontane sli ar ar -Okis hasbeendinvided in to -4 planes t C C Plane Rovina eueballsJhio plare cnds Suohen become. ised Plane oss. of covmeal ondlavyngeal refleres a a rm rm plens 2 ppi tardilotmiiandheht vefiex ha ha ha is Jast lP lP lP glone Sntenoatal paralysisshallo obaominal abdomnal el el TEspiration, dilated pupil ew ew atage Medulley RAvalysis ar ar C C tessation ot bsealking to ailune of Cixulation Ond dcalh. fupil is dely dilated muscles are otall a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 16 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar flabbyPulse hTeady(oy impercertbe md 5 C C 6P i5 vey Clossiceton generaljanocsikekea Jhey ore classihicd a a rm rm Snbalationol - N ha ha ha Sntavenous lP lP lP bsnhalational: el el ew ew Jolatile liquidls ar ar Nitrous oxide EEher isotlurone C C Malohane, destlurane Jevofuiane nhalational anaasthetics caist in ; tuoo a a Siqid rm rm gas y ha ha ha Swtoavenou T i lP lP lP Subclassikedtti a el el sladar actg ew ew oactng duga Benzeciozepiz ar ar hioparttone Sad pàm, t diazepam, Xora2e C C Mehoheitone Sod midaólam. i progeol aroeshesa ydisaoeiate ketamine to midate ogold ovalaesia-tontanyl. a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 17 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar harmacokinotics avacsthetics C C qases Nopours -Suhalational anacsthetics are 09Napu across plulmonanyaveok |hat diffuse rapidy a a and tisue barricrs rm rm -She ot phormacokiveticsinicude ha ha ha PTinciple lP lP lP inductionmaintainencef TCCONery el el Snduction ew ew the ar ar -9t is he time interval betmen he admmistr C C artion ot OMacshefic druq and he develome nt of staqeo of Surgical anaethesia. hilicity is key toctor ovemin phaimatbkinet- a a rm rm ic3 ofinaucinq ha ha ha Mointainance lP lP lP -4 ise period dunnqohich thë paient el el ew ew Temain IM a 3ustainecd stageofisurqical ar ar onaesthesid; C C 4 -Ouring hs is staget age, theanaesthesjoloqit monror he patients vital sign and Tespone2 a a rm rm Website For Notes & More :- www.carewellpharma.in ha ha ha Provided By - Chandu Brother P P P l l l el el Page 18 of 46 ew ew CAREWELL PHARMA - A FAMILY OF LEARNING search CAREWELL PHARMA on Youtube, Watch free Video Lectures ar ar varlausstimuli" ContiollinqCoeentra hon b C C hased anaeshetic to beinlaled CTifuzd depihof anacsthesid oM o Kecover a a rm rm Ahe rocove1 phasetarls ohen tha onacstheh ha ha ha Atsc(ontinue d lP lP lP drug anacsthesioloqist has to el el this phase the burinq ew ew