ppp.pdf

Blood products therapy transfusion medicine blood transfusion Professor Dr.Mohamed Hamdy professor of Internal Medicine and Clinical Hematology Ain Shams University Dr.Mohamed Hamdy At the end of this lecture the student...

Blood products therapy transfusion medicine blood transfusion Professor Dr.Mohamed Hamdy professor of Internal Medicine and Clinical Hematology Ain Shams University Dr.Mohamed Hamdy At the end of this lecture the student should be able to: present types of blood product List types of RBC product and their indications. Link the level of hemoglobin drop and clinical manifestation. List indication of RBC, platelet and plasma transfusion. Describe compatibility testing for transfusion (blood grouping) Describe early and late transfusion reactions(complicarions) Dr.Mohamed Hamdy Transfusion products Dr.Mohamed Hamdy Dr.Mohamed Hamdy Preparations of Red Cells for Transfusion Packed RBC most transfusions Each unit has a volume of about 300 mL. One unit of packed red cells will usually raise the hemoglobin by approximately 1 g/dL. whole blood rarely used now massive hemorrhage when more than 10 units of blood is required cardiac surgery exchange transfusion washed remove plasma and platelet leukoreduced blood products reduce the incidence of leukoagglutination reactions, platelet alloimmunization, transfusion-related acute lung injury, and cmv exposure. irradiated kill leukocyte CMV negative Immunodeficient Seronegative Hematological malignancy Dr.Mohamed Hamdy Hemoglobin Level and Symptoms HGB (GM%) SYMPTOMS 9-11 MINIMAL 7.5 EXERTIONAL DYSPNEA 6.0 WEAKNESS 3.0 DYSPNEA AT REST 2-2.5 HEART FAILURE LINMAN NEJM 279:812, 1968 Dr.Mohamed Hamdy RBC Transfusion: Indications Acute Blood Loss Symptomatic Anemia Suboptimal O2 Capacity Exchange (SS, Co) Dr.Mohamed Hamdy Platelet concentrate Platelet concentration Indication (thrombocytopenia) One adult dose is made : < 10 in AML four donations of whole blood.