PCH 301 Selected Synthetic Methods in Medicinal Chemistry PDF

# PCH 301 ## Selected Synthetic Methods in Medicinal Chemistry ### Introduction There are two fundamental goals of every research study carried out in medicinal chemistry, which are: 1. To discover and 2. To develop new natural or synthetic organic compounds of biomedical utility. Consequently, or...

# PCH 301 ## Selected Synthetic Methods in Medicinal Chemistry ### Introduction There are two fundamental goals of every research study carried out in medicinal chemistry, which are: 1. To discover and 2. To develop new natural or synthetic organic compounds of biomedical utility. Consequently, organic synthesis is a central task in any pharmaceutical development endeavour. In recent times, intensive organic synthesis and medicinal chemical target-related research activities include the following: 1. Total synthesis of natural products 2. Asymmetric synthesis 3. Development of new methodologies 4. Studying reaction mechanisms 5. Investigations of structure-activity-relationship (SAR) 6. Creation of new structural scaffolds 7. Synthesis of biomimetic non-natural compounds The process of establishing a new pharmaceutical is exceeding complex and therefore requires constant development of new reactions, catalysts and techniques as well as, employing a productive collaboration with talents of people from various disciplines: chemistry, biochemistry, molecular biology, physiology, pharmacology, pharmaceutics and medicine, which is mandatory for the realization of the intended goals and pursuits. Scientists responsible for the task of synthesizing new organic compounds are called synthetic chemists or medicinal chemists, while the establishment where such synthesis is carried out is called the synthetic industry. Some examples of types of synthetic drugs are: 1. Synthetic cannabinoids 2. Phenethyl amines 3. Synthetic opioid monomers 4. Tryptamines 5. Piperazines 6. Benzodiazepines The synthesis of any new organic compound is a multi-step process having three fundamental synthetic tasks that must be accomplished as outlined below: 1. Constructing the carbon framework or skeleton of the desired molecule. 2. Introducing, removing or transferring functional groups in a fashion that achieves the functionality of the defined compound. 3. Exercising selective stereochemical control at all stages, in which stereoisomerism is created or influenced. As a matter of crucial emphasis, the second task which projects functional groups is in actual fact, the cardinal task because functional group is a fundamental link to the sectors of the synthetic industry, even though, it operates in the sectors by different mechanisms of action.