Immunology Final 2023 PDF

Immunology Final MCQ Chapter1: Introduction to the Immune System MCQ Which innate immune cell migrate to active adaptive immune response? A. NK cells B. Macrophage C. Neutrophil D. Dendritic cell. E. Platelets What is the feature of agr...

Immunology Final MCQ Chapter1: Introduction to the Immune System MCQ Which innate immune cell migrate to active adaptive immune response? A. NK cells B. Macrophage C. Neutrophil D. Dendritic cell. E. Platelets What is the feature of agranulocyte? A. Visible granule and polymorphonuclear B. Invisible granule and polymorphonuclear C. Visible granule and monomophornuclear D. Invisible granule and monomophornuclear. Among which one cell is not derived from CLP A. T cells B. B cells C. NK cells D. Plasma cells E. Macrophage. What is the feature of granulocyte? A. Visible granule and polymophornuclear. B. Invisible granule and polymophornuclear C. Visible granule and monomophornuclear D. Invisible granule and monomophornuclear What is the origin of blood stem cells? A. MSC B. HSC. C. CLP D. CMP Where do CLP differentiated from? A. HSC B. MSC. C. Plateletes D. Mast cells Among which one cell type is not belong to innate immune cells ? A. Plasma cells. B. Dendritic cells  C. Monocytes D. Basophill E. Megaryocyte All are peripheral lymphoid organs except A. Lymph node B. Spleen C. Peyer patch D. Tonsil E. Thymus. Which feature is not belonged to innate immunity? A. Early response B. No clonal expansion C. Have memory. D. Less specificity E. Low diversity The cell that responsible for humoral immunity is A. Th cells B. CD8T cells C. CD4T cells D. NK cells E. B cells Chapter 2: Innate Immunity The Early Defense Against Infections MCQ: Precursor cell of Macrophage is A. MSC B. DC C. Monocyte. D. Platelet E. MC Innate immune cell that kill virus infected cells is A. B cell B. NK cell. C. Platelet D. Mast cell E. DC Monocytes differentiate into A. Tc B. NK C. MC  D. MP. Macrophage E. DC One of the cell types is not phagocyte. A. Monocyte B. DC C. Macrophage D. Neutrophil E. NK. Cell that do NOT derived from CPL A. MC. B. Plasma cells C. T cell D. NK cells E. B cells Cell that do not play role in immune response A. DC B. Platelet C. NKT D. WBC E. RBC. Receptor that responsible for extracellular pathogen: A. Toll-like receptor. B. CDS C. NOD-like receptor D. RIG-like receptor E. T cell receptor Pathogen recognition receptor that responsible for inflammasome is : A. Lectin receptor B. RIG-like receptor C. CDS D. Toll-like receptor E. NOD-like receptor. The purpose of inflammasome induction is A. Eliminate microbe B. Degrade protein C. Induce inflammation through IL-1 beta. D. Increase permeability of blood vessel E. Kill abnormal cell One cell type is not located in epithelial barrier:  A. HSC. B. Cutaneous cells C. Largerhan cell D. IEL cells E. Mucosal tissue Main function of histamine: A. Kill virus-infected cells B. Kill abnormal cell C. Direct induce inflammation D. Increase permeability of blood vessel. Cell that migrate to peripheral lympoid organ to activate adaptive immune response is: A. Neutrophil B. MSC C. MP D. NK E. DC. Antibodies-dependent cellular cytotoxicity (ADCC) in NK cells is mediated by: A. Lectin receptor B. RIG-like receptor C. NOD-like receptor D. Toll-like receptor E. CD16 receptor. The cellular receptor that involves in the phagocytosis is. * A. IL-1 receptor B. NOD-like receptor C. Cytosolic DNA sensor D. Toll-like receptor E. C-type lectin receptor. What is the main player protein in complement system? A. C3 B. C2 C. C4 D. Factor B E. C5 All are phagocytes Except * A. B cells B. DC C. T cells. D. MP E. Neutrophil Innate immune cell plays dominant role in blood circulation is * A. Basophil B. DC C. Macrophage D. IEL cell E. Neutrophil. Among which one function is NOT trigger by Complement System activation A. Clonal expansion. B. Induce inflammasome C. Direct lysis the microbes D. Induce phagocytosis All are antimicrobial peptides (AMP) except * A. Keratin B. Defensin C. Abs. D. Cathelicidin E. Granzyme B Enzyme that converts Non-toxic oxygen containing molecule into ROS is * 1/1 A. Phagocyte oxidase. B. INOS C. Lysosomal protease D. Phosphatase E. Kinase Among which one enzyme is NOT involved in the Phagocytosis * A. INOS B. Phagocyte oxidase C. Lysosomal protease D. Kinase. Cytokine that enhances the phagocytosis is * A. Perforin B. IL-4 C. TNF D. IFN-gamma. E. IL-1 NK cells kill virus-infected cells by using. * A. Keratin B. Granzyme B. C. Defensin D. Cathelicidin  E. Streptomycin T cell that involves in innate immunity is * A. Plasma B cells B. B cells C. CD8 T cells D. CD4 T cells E. NKT cells. Chapter 3: Antigen Capture and Presentation to Lymphocytes “MHC structure, Antigen processing and presentation” MCQ: Co-stimulation ligand for CD28 receptor of T cells is A. CD40 B. TNF-alpha C. IL-1 receptor D. B7-1/B7-2 ligand. E. TLR ligand Non-protein molecules such polysaccharide, lipid, and nucleic acid can be displayed to A. T regulator cells B. NKT cells. C. CD8 T cells D. CD4 T cells E. CTL DC that located on skin epithelial barrier is A. FDC B. iDC C. pDC D. MC E. LC. What is the function of Ubiquitin protein in MHC class I pathway? A. Signal transduction B. Transcription factor C. Dephosphorylate protein D. Phosphorylate protein E. Tag protein for degration. MHC class II molecule is composed of A. alpha chain and beta2m proteins B. TCR, CD3 and Zeta protein C. alpha chain and beta chain proteins. D. BCR, Ig alpha and Ig beta Special feature of APC is A. Expressed MHC class II. B. Expressed MHC class I C. Expressed B7 protein D. Present to CD8 T cells E. Kill infected cells Cell that could not express MHC-class I molecule is A. Basophil B. Platelet C. Interstitial DC D. Epithelium E. Erythrocyte. Which protein complex function to degrade Ubiquitinated proteins? * A. Proteasome. B. Phagocyte oxidase C. Lysosomal protease D. Phosphatase E. iNOS How many polymorphic gene of HLA genes for class I and class II MHC ? * A. 2 B. 5 C. 6. D. 4 E. 3 Non-protein molecules such polysaccharide, lipid, and nucleic acid can be displayed through A. CD40 B. TCR C. MHC class II D. MHC class I E. CD1. Two signaling require to activate DC are * A. Capture antigen and TLRL or cytokine. B. CD28L and IFN-gamma C. IFN-alpha and IFN-beta D. CD40L and IFN-gamma E. Antigen peptide and CD28L A receptor that functions to capture microbial antigen is A. CCR7 B. CLR. C. CXCR5 D. TLR E. CD16 MHC class I molecule is composed of A. alpha chain and beta chain proteins B. TCR, CD3 and Zeta protein C. alpha chain and beta2m proteins. D. BCR, Ig alpha and Ig beta E. TLR1-TLR2 Chapter4: Antigen Recognition in the Adaptive Immune System MCQ: One enzyme is NOT involved in somatic recombination of gene for Ig and TCR A. TdT B. Ligase C. Exonuclease D. Phagocyte oxidase. E. VDJ recombination Which Ig is having the longer half-life? A. IgA B. IgM C. IgG. D. IgE E. IgD All are proteins in TCR complex except A. TCR B. CD4. C. CD3 D. Zeta Effector function of Ig is A. Fab region B. Variable domain C. CDR loop D. Paratope E. Fc region. All are proteins in BCR complex except * A. Ig alpha B. Ig beta C. BCR D. Membrane Ig E. Alpha chain. Enzyme that involved in VDJ gene segment recombination is * A. VDJ recombinase. B. Ligase C. Protease D. TdT E. Exonuclease Function of TCR in the TCR complex is * A. Antigen peptide recognition B. Transduce signal C. Capture microbial antigen D. Activate DC cells. E. Induce inflammation Which gene segment determines isotype of Ig? A. Constance gene segment. B. V gene segment C. D gene segment D. J gene segmen How Ig and TCR have so much diversity for diversity antigens? A. Because they are polymorphic genes B. Because their genes got mutation C. Through somatic recombination of genes. D. Through inflammasome E. Through infection Membrane Ig that expressed on B cells is A. IgE B. IgG C. IgM. D. IgA1 E. IgA2 Chapter5: T Cell-Mediated Immunity MCQ What is apoptosis? a) Degrade microbial antigen b) Inflammatory c) Program cell death d) Tissue repair e) Antigen capture Which subset cells are not derived from Th cells? a) Th1 cell b) Th17 cells c) T cytotoxic cells d) Th2 cells e) T reg Which cellular receptor that T cell use to recognize antigen peptide? a) CD4 b) CD3 c) Zeta d) CD28 e) TCR which cellular receptor that T cell use to recognize co-stimulation ligand? a) TCR b) CD28. c) CD3 d) Zeta e) CD8 One enzyme is NOT involved in somatic recombination of gene for Ig and TCR a) TdT b) Ligase c) Exonuclease d) Phagocyte oxidase e) VDJ recombinase Which receptor expressed on T cell help them migration to T cell zone? a) CXCL10 b) CXCR3 c) CCR7 d) CD4 or CD8 e) TCR What is the target receptor for death ligand PDL-1 or PDL-2? a) PD1 b) CTLA-4 c) TCR d) CD28 e) LFA-1 What is the growth factor of T cells? a) IFN-gamma b) CD40L c) TNF d) IL-1 e) IL-2 Which cellular receptors that lately express at the end of infection? a) CTLA-4 b) CD69 c) CD28 d) IL-2R e) LFA-1 What is the function of enzyme kinase? a) Phosphorylate other proteins b) Degrade other proteins c) Tag other proteins d) Dephosphorylate other proteins e) Proliferation Chapter6: Effector Mechanisms of T Cell-Mediated Immunity What is the cytokine profile of Th-2 cells? a) IL-12 and IFN-gamma b) IL-17 and IL-22 c) IL-1 and TNF d) IL-4, IL-5, and IL-13 e) IL-10 and TGF-beta What signaling required to activate the classical M1 activation of macrophage from monocyte? a) TGF-beta b) IL-10 c) IFN-gamma or TLR-L d) IL-4 and IL-13 e) IL-2 In order to differentiate Th cells into Th-2 cells, what kind of infection is required? a) Bacteria b) Parasites c) Fungi d) Virus e) Mycobacteria Which cytokine could convert monocyte into an alternative M2 activation? a) IL-2 b) B7-1 and B7-2 c) IL4 and IL-13 d) IFN-gamma e) TGF-beta What is exhausted T cell? a) Poor function and express CTLA-4 and PD-1 b) Functionally active c) Could kill virus-infected cells d) Induce inYammation e) Perform phagocytosis How CTL or NK cells kill virus-infected cells? a) Granzyme and perforin b) Keratin c) defensin d) cathelicidin e) PDL-1 and PDL-2 What is the co-receptor to TCR in cytotoxic T cells? a) CD4 b) CTLA-4 c) TCR d) CD28 e) CD8 What is the cytokine profile of Th-17 cells? a) IL-17 and IL-22 b) IL-1 and TNF c) IL-4, IL-5 and IL-13 d) TGF-beta and IL-10 e) IFN-gamma What is the co-receptor to TCR expressed on Th cells? a) TCR b) CD4 c) PD-1 d) IL-2R e) CD28 Which cytokine is required to differentiate Th cells into Th2 cells? a) IL-4 b) TNF-alpha c) IL-22 d) IL-2 Which cytokine is required to differentiate Th cells into Th1 cells? a) IL-1 b) IL-2 c) TNF d) IL-4 e) IL-12 or IFN-gamma Chapter7: Humoral Immune Responses and Effector mechanism What additional cytokine required to differentiate FO B cells into IgE-expressing plasma cells? a) IL-2 b) IL-1 c) IL-5 d) IL-10 e) TGF-beta Which B cell type undergo T-dependent activation? a) Platelet b) Plasma c) MZ cells d) B1 cells e) FO B cells What is the function of Tfh and FDC in activated B cells selection? a) To maintain IgM expression in plasma b) Function as Ag presenting cells c) Selected the high affinity Abs producing plasma cells d) Selected the low affinity Abs producing plasma cells What additional cytokine required to differentiate B cells into IgG-expressing plasma cells? a) IL-2 b) IL-4 c) IL-5 d) IL-10 e) TGF-beta Which B cells undergo Heavy-chain isotype switch? a) FO B cells b) B1 cells c) MZ B cells d) Plasma cells e) MC What kind of secreted antibody could be produced under T-independent activation? a) IgM b) IgG c) IgA d) IgE e) IgD What signal that T cell provide to activate FO B cells? a) IL-4 and IL-5 b) IL-1 and TNF alpha c) CD40L and cytokine d) IL-4 and IL-13 e) PDL-1 and PDL-2 How could Tfh cell migrate to follicular tissue? a) CCR7↑ and CXCR5↓ b) Increase LFA-alpha c) IL-1 and TNF receptor d) CCR7↓ and CXCR5↑ e) Secreted Ig Which membrane Ig are constantly (continuously) expressed on membrane of naive and activated B cells? a) IgG b) IgA c) IgE d) IgM e) IgD Which enzymes play role in the H-chain isotype switch Abs? a) Phagocyte oxidase b) Ligase c) AID d) Protease e) TdT Why IgD remain expression in plasma B cells? a) Because its constant gene does NOT have switch region b) Because its constant gene have switch region c) Because No need T-dependent activation d) Because it undergo T-dependent activation What are the two signaling require to activate FO B cells? a) Stimulation ligand b) Microbial antigen and T-dependent activation c) Microbial antigen and PAMPs d) Antigen peptide and B7-1 e) IL-12 and IFN-gamma What are BCR complex made of? a) Membrane Ig, Ig-alpha, and Ig-beta b) alpha chain and beta chain c) TCR, CD3 and Zeta d) IL-2R alpha and IL-2R beta e) alpha chain and beta 2 m What is the function of Germinal center in follicular tissue? a) The place where B cells kill infected cells b) The place where B cell proliferated and differentiated into plasma cells. c) The place where T cells located. d) The place where inflammasome initiated e) The place where DC migrate to activate T cells. Chapter8: Effector Mechanisms of Humoral Immunity Which is not the function of complement system? a) induce inflammation b) direct kill microbe c) degrade proteins d) Opsonize microbe e) Induce phagocytosis How IgA are transported across the epithelial barrier to the lumen? a) by Toll-like receptor b) by Poly-Ig receptor c) by LFA-1 receptor d) by secreted Ig e) by TNF-alpha Which Th cells mediated activation to differentiate FO B cells into IgE-expressing plasma cells? a) Th17 cells b) Th1 cells c) Th2 cells d) Treg e) CTL What is the function of C3a and C5a in the complement activation? a) Induce inflammation b) cytotoxic molecules c) direct kill microbes d) activate NK cells e) Induce antiviral activation Which NK receptor involve in antibody-dependent cell cytotoxicity (ADCC)? a) CD56 b) CD16 c) TLR d) CLR e) IL-1 receptor What is the purpose of making membrane attack complex (MAC) in complement activation? a) Induce osmotic cell lysis b) induce inflammation c) activate neutrophil d) activate NK cells e) Induce phagocytosis How neonates (newborn) protect themselves from infection? a) have ready immune response b) could produce sufficient Ig to protect themselves c) have strong immune system already d) through themselves e) through obtaining Ig from mother Which B cells are most abundant? a) FO B cells b) B1 cells c) MZ B cells d) Plasma cells e) NK Which Ig isotype mediated killing of parasites? a) IgM b) IgA c) IgE d) IgG e) IgD The protein that play key role in the complement activation is a) Factor D b) Factor B c) C5 d) C3 e) C9 Which Ig have higher concentration and more subtype than other Ig isotype? a) IgM b) IgE c) IgA d) IgG e) IgD Which Abs play role in mucosal immunity? a) IgA b) IgD c) IgM d) IgG e) IgE How IgG antibodies are uptake by cells and recirculate back? a) uptake by lectin receptor b) uptake by Toll-like receptor c) uptake by CD16 receptor d) Uptake by ICAM1 e) uptake by Fc receptor called FcRn