CRA_New+and+Integrated_for+11-13-2023_TO+POST copy.pdf

Page 1 of 4 MRSL III: Activity 1 for 11-13-2023 Part 1: Instructions: Select the antimicrobials that in general have activity against the pathogen given # Organisms Option A Option B Option C 1 Hepatitis B Lamivudine Abacavir TDF 2 Influenza Remdesivir Oseltamivir Baloxavir 3 CMV G...

Page 1 of 4 MRSL III: Activity 1 for 11-13-2023 Part 1: Instructions: Select the antimicrobials that in general have activity against the pathogen given # Organisms Option A Option B Option C 1 Hepatitis B Lamivudine Abacavir TDF 2 Influenza Remdesivir Oseltamivir Baloxavir 3 CMV Ganciclovir Foscarnet cidofovir 4 HIV TAF efavirenz nirmatrelvir 5 COVID-19 Remdesivir Molnupiravir Paxlovid® 6 HIV Rilpivirine Rifabutin rifampin 7 Mycobacterium tuberculosis Isoniazid Rifampin Ethambutol 8 MRSA Linezolid Daptomycin Bactrim® 9 RSV Ribavirin Lamivudine darunavir 10 B. fragilis Cefepime Metronidazole Meropenem 11 HSV Letermovir Valacyclovir Penciclovir 12 VZV Valganciclovir Valacyclovir Foscarnet 13 P. aeruginosa Cefepime Meropenem Moxifloxacin 14 CMV Letermovir Famciclovir Valganciclovir 15 Influenza Zanamivir Peramivir Penciclovir For educational purposes only Page 2 of 4 • Part 2:Instructions: Navigate https://hivinfo.nih.gov/home-page ; Utilize appropriate clinical guidelines (hint: use tables) to answer the following questions # Question 1 3 What is the recommendation for drug-resistance testing: a. In early (acute and recent) HIV b. Before ART initiation in patients with chronic HIV What is the recommendation for genotypic testing in people with prior exposure to INSTIs for PrEP? What regimens should be taken with food? 4 What regimens should be taken on an empty stomach 5 What medication is recommended to be avoided in patients with osteoporosis? What is recommended to avoid in patients with pre-existing psychiatric conditions? What regimen should be considered in patient with a history of poor adherence to non-ARV medications or inconsistency in follow-up visits, etc.? Why? What is recommended if a patient has a co-infection with HBV? 2 6 7 8 9 10 11 A patient is on a DRV/c-based regimen. Would it be appropriate to initiate alfuzosin in this patient? Why or why not? Why is rifampin contraindicated with all PIs? Can rivaroxaban be administered when the patient is receiving darunavir/cobicistat? For educational purposes only Your response and include table # where you obtained the information from: Page 3 of 4 12 13 14 What is the recommendation regarding: a. DRV/r and phenytoin b. DRV/c and phenytoin What is the recommendation regarding: a. Bictegravir and Tums Explain your response What is the recommendation regarding: a. Raltegravir and pantoprazole b. Rilpivirine IM and pantoprazole c. Rilpivirine PO and pantoprazole Explain your response For educational purposes only Page 4 of 4 Part 3: Instructions: Select all that apply # Clue Option A Option B Option C 1 Allergy – angioedema Potassium Heart failure Pregnancy 2 Lisinopril contraindicated in a patient with Elevated due to hydrochlorothiazide Magnesium Calcium 3 Available as an IV formulation azithromycin valganciclovir sitagliptin 4 Diarrhea as a side effect clarithromycin amoxicillin levofloxacin 5 QTc prolongation as a side effect ciprofloxacin cefpodoxime amiodarone 6 Indicated for diabetes type 2 treatment liraglutide empagliflozin insulin detemir 7 Interacts with warfarin: metronidazole levofloxacin 8 Peripheral edema as a side effect torsemide trimethoprimsulfamethoxazole lactulose 9 Available as a PO formulation enoxaparin apixaban semaglutide 10 Indicated for Alzheimer’s disease treatment rivastigmine ropinirole rivaroxaban 11 Indicated for certain seizures levetiracetam Imipenem-cilastatin foscarnet 12 Anti-emetic agent metoclopramide ondansetron loperamide 13 OTC option for cough dextromethorphan guaifenesin benzonatate 14 Indicated for rate control for atrial fibrillation 15 Indicated for HFrEF amlodipine carvedilol rivaroxaban empagliflozin sacubitril/valsartan chlorthalidone For educational purposes only amlodipine