2022 HMM304 Wk01 Cl03 ONLINE Penicillin and nitrogen mustards as chemotherapy drugs.pdf

HMM304: Therapeutic Development https://images.medicinenet.com/images/appictures/muscle‐cramps‐s21‐medications.jpg Week 1, Class 3 – ONLINE ONLY Non-targeted discovery & subseque...

HMM304: Therapeutic Development https://images.medicinenet.com/images/appictures/muscle‐cramps‐s21‐medications.jpg Week 1, Class 3 – ONLINE ONLY Non-targeted discovery & subsequent drug development of penicillin and nitrogen mustard chemotherapy drugs Dr Craig Smith HMM304 Unit Chair School of Medicine Deakin University CRICOS Provider Code: 00113B [email protected] Non-targeted drug discovery (& development) Three major types of non-targeted drug discovery 1. Natural product 2. Chemistry-driven drug discovery drug discovery Synthetically make Find natural products chemical variants Drug discovery 3. Drug repurposing / research repositioning Find a new use for an Useful lead compounds existing drug Drug development (no longer part of drug discovery) NOTE: These three processes can occur as part of: Non-targeted drug discovery (our focus for today) AND Targeted drug discovery Non-targeted drug discovery (& development) E.g. Penicillin (Links to all this material are in CloudDeakin, in the week 1 ‘Online class material’ section) Tasks: 1. Read the article ‘Maker of the Miracle Mould’ 2. View ‘Fleming, Florey and Chain Secondary History Medicine Through Time’ (Please note – in the RECORDING of this lecture, I instead list ‘H5P: Penicillin – The Magic Bullet’. However, this is no longer available, and so have replaced it with Task 2 above) Non-targeted drug discovery (& development) E.g. Nitrogen mustard gas chemotherapy drugs Tasks: 1. Read the article ‘Mustard gas – from the Great War to frontline chemotherapy’ 2. View ‘H5P: The birth of chemotherapy’ Note: H5P software allows the inclusion of questions and other items at various points in the video. You have to answer these successfully in order to progress to the next part of the video (the navigation bar is locked)  Learning Objectives, ONLINE Class 3 Cl03 – 01: Describe key features of the discovery and development of penicillin. Cl03 – 02: Describe key features of the discovery and development of nitrogen mustards as chemotherapy drugs.