HMM304: Therapeutic Development - Week 1, Class 3
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Questions and Answers

What is the main difference between non-targeted drug discovery and targeted drug discovery?

  • Non-targeted drug discovery involves finding natural products, while targeted drug discovery involves synthetically making chemical variants.
  • Non-targeted drug discovery involves finding a new use for an existing drug, while targeted drug discovery involves drug repurposing.
  • Non-targeted drug discovery involves identifying a specific disease target, while targeted drug discovery involves screening for compounds that affect a specific target. (correct)
  • Non-targeted drug discovery involves identifying a specific disease target, while targeted drug discovery involves finding a new use for an existing drug.
  • What is the primary goal of drug development?

  • To find a lead compound with potential therapeutic effects
  • To test a compound's safety and efficacy in humans (correct)
  • To synthetically make chemical variants of a natural product
  • To identify a specific disease target for drug development
  • Which of the following is an example of non-targeted drug discovery?

  • Designing a compound to target a specific receptor
  • Identifying a new disease target for an existing drug
  • Screening a library of compounds for activity against a specific disease
  • Discovering penicillin from a natural source (correct)
  • What is the primary goal of drug repurposing?

    <p>To find a new use for an existing drug</p> Signup and view all the answers

    What is the difference between drug discovery and drug development?

    <p>Drug discovery involves finding a lead compound, while drug development involves testing its safety and efficacy</p> Signup and view all the answers

    Which of the following is an example of chemistry-driven drug discovery?

    <p>Synthetically making chemical variants of a natural product</p> Signup and view all the answers

    What is the main advantage of non-targeted drug discovery?

    <p>It increases the chances of finding a lead compound with potential therapeutic effects</p> Signup and view all the answers

    What is the primary goal of natural product drug discovery?

    <p>To find a lead compound with potential therapeutic effects</p> Signup and view all the answers

    Study Notes

    Non-Targeted Drug Discovery

    • There are three major types of non-targeted drug discovery:
      • Natural product drug discovery: finding natural products
      • Chemistry-driven drug discovery: synthetically making chemical variants
      • Drug repurposing/repositioning: finding a new use for an existing drug

    Non-Targeted vs Targeted Drug Discovery

    • Non-targeted drug discovery can occur alongside targeted drug discovery
    • Non-targeted drug discovery is the focus for this topic

    Examples of Non-Targeted Drug Discovery

    • Penicillin: an example of non-targeted drug discovery
    • Nitrogen mustard chemotherapy drugs: also an example of non-targeted drug discovery

    Important Tasks

    • Read the article 'Maker of the Miracle Mould' to understand more about non-targeted drug discovery

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    Description

    This quiz covers the non-targeted discovery and subsequent drug development of penicillin and nitrogen mustard chemotherapy drugs. Learn about the history of these important medications.

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