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## Mitosis and Apoptosis ### Mitosis 6. In which stage of Mitosis does the nucleolus disappear? _**Prophase**_ 7. Structure where the assembly of microtubules of the mitotic spindle begins: _**Centrosome**_ 8. What is the function of proteins encoded by tumor suppressor genes? _**To prevent un...

## Mitosis and Apoptosis ### Mitosis 6. In which stage of Mitosis does the nucleolus disappear? _**Prophase**_ 7. Structure where the assembly of microtubules of the mitotic spindle begins: _**Centrosome**_ 8. What is the function of proteins encoded by tumor suppressor genes? _**To prevent uncontrolled cell growth**_ 9. Mechanism by which the number of animal cells is regulated: _**Apoptosis**_ 10. Apoptosis is mediated by: _**A proteolytic cascade**_ 11. Mechanism by which the number of animal cells is regulated: _**Apoptosis**_ 12. In prometaphase, the chromosomal material called chromatin condenses. _**False**_ 13. In the G2 phase, the transcription and translation of genes that encode proteins necessary for cell division are observed. _**True**_ 14. In animal cells, cytokinesis occurs through segmentation. _**True**_ 15. In telophase, the mitotic spindle breaks down, the nucleolus reappears, and a nuclear membrane forms around the chromosomes. _**True**_ 16. Checkpoint where complete DNA replication is verified: _**G2**_ 17. In cell cycle regulation: Cyclin levels rise and fall 18. What is an internal control signal of the M phase? _**Alignment of chromosomes on the metaphase plate**_ ### Apoptosis 19. What happens when cells do not respond to control mechanisms? _**They produce cancer cells**_ 20. Apoptosis is: _**Programmed cell death**_ 21. In necrosis, a cell: _**Bursts, spilling its contents**_ 22. What is the function of the apoptosome? _**Activate procaspase-9**_ 23. In the proteolytic cascade, the activation of effector caspases is due to: _**Cleavage of their prodomains**_ 24. Factors that stimulate cell growth: _**Growth factors**_ 25. Phase of the cell cycle where cell growth occurs: _**G1**_ 26. Stage of Mitosis where the nuclear envelope fragments: _**Prometaphase**_ 27. Cells that undergo apoptosis: _**Die cleanly**_ 28. Apoptosis is mediated by: _**An intracellular proteolytic cascade**_ 29. What is considered a tumor suppressor gene? _**p53**_ 30. Necrosis is characterized by: _**Bursting and swelling**_ 31. How many procaspases are required to form an active caspase? _**Two**_ 32. After cleavage of the prodomains, procaspases must: _**Assemble**_ 33. What is the name of the phase where an active caspase can activate many other caspases? _**Amplification**_ 34. What event can occur in a cell when a proteolytic cascade is activated? _**Nuclear lamina degradation**_ 35. What must happen to procaspases in order to form an active caspase? _**Cleavage and assembly**_