V-ASAnal_Skript_WS2324 (1) (verschoben) 3.pdf - Chemistry Notes

CH3 OH HN NH2 OH HN NH NH...

CH3 OH HN NH2 OH HN NH NH H2N N O CH3 O OH N H2N N N HO O OH N NH2 H H CH3 O CHO Guanethidin Metformin N OH CH3 OH H2N NH2 Streptomycin Cl NH2 NH2 H H N N N CH3 N N N N N N H NH2 NH2 CH3 NH2 NH2 Cl Cl Chlorhexidin Proguanil  O N O O H 1 1 2 R R R 1 2 O N R R O R 2 H O O (H+) oder (OH-) OH + H2O HO  N H Pyrrol N Pyridin – ³ R O CH3 (H+) 2 + N N H CH3 - H2O H R R H H NH N C+ N N Fe3+ H H R R N H3C CH3 N H3C CH3 ³ R R R O O H (H+) 2 + N H OH - H2O N N H H O OH H R Fe3+ NH - CO2 C+ N H H R  H OH + Cl NO 2 N NO 2 + OH- N + N NO 2 - Cl- O 2N O 2N O 2N H OH O N N+ N NO 2 - H O - H+ - O O 2N O 2N H H2 N N + + N Br C N N C N - - Br - H+ N C N H H H N N N H N H2 N N + H2O H C N - H2N-CN N HN N - OH- + N C H N  O O O H H H H N Ox. N Ox. N N N HN HN HN O N N O N N O N N N N H H H Purin Hypoxanthin Xanthin Harnsäure O CH3 O O CH3 H H3C N H3C N N N N HN O N N O N N O N N CH3 CH3 CH3 Coffein Theophyllin Theobromin  O O O H H O N HNO3 NH2 O N HN HN HN O O N N O N O N O O N O O H H H H H Uramil Alloxan Parabansäure hydrolytisch oxidativ oxidativ (H+) - H2O O O O O HN HN N + NH3 N NH NH + O O NH4 N N - H O O N O H O O N O H H H Murexid aus Harnsäure O CH3 O O H3C O H3C N H3C O N N H2O2 / HCl N NH3 N CH3 O O N + NH4 O N N O N N N - O O N O CH3 CH3 OH H3C CH3 Murexoin (rotviolett) O X O HN X = O, NH N HN O NH Y = O, S N Y N - H O O N O H H Murexid aus Harnsäure  O CH3 O CH3 H3C N - H3C N H2O, OH N N H Coffeidin O N N - HCO3- N HN CH3 CH3 O CH3 O O CH3 H H3C N H3C N N N N HN O N N O N N O N N CH3 CH3 CH3 Coffein Theophyllin Theobromin O CH3 H3C O O CH3 CH3 N N H3C O H3C H N N+ N H2O N H3C H N H + H3C N H3C N HN N - 2 OH- N+ H3C O H3C CH3 CH3 H3C H3C O O H3C CH3 H3C O N H N+ +2 N H3C H3C H N+ N - 2 H2O H3C CH3 N N CH3 CH3  - - N N + + - N N N SO 3 - N N SO 3 N R R O O O - - + - H3C - - H3C H3C N N SO3 N N + 2 H2O (OH-) N N N N N SO 3 H H N N - CO2 N N O N HN HN CH3 CH3 CH3  O H N O N H O 1 O H3C H3C O R 2 H O R O R H OH OH N H NH2 N N O O N Co N O N Co N O NH 1 HO OH R 1 H2N R 2 2 2 R O CH3 CH3 O R R 1 O R O R ² R 1 2 O N O R H N O N Cu N O N 1 H 2 R O N O R H3C O H3C O H3C O H H H N N N O H3C S N N N H H H3C O H O O Phenobarbital Primidon Thiopental O H H O N N N NH HN N N Cl O O Phenytoin Domperidon  O NO 2 1 N R 2 O R N O NO 2 Ö – – O + O N H3C O CH3 NO 2 R N HNO3 R (CH3)2CO / OH- O O + N N - H2O – H O H O O 2N H3C O  2 R O N ² R 3 ³ 1 R N 4 R „ “ 2 2 R R O O N NH HO + + 2 H2O (H ) / R 3 + R 3 1 1 O R N R H2N 4 4 R R ² H O O N NH2 HO + 2 H2O (H+) / R 3 + R 3 1 1 O R N R H2N 4 4 R R  – ² ¹ ³ H O – O O N N N 3 3 3 R R R + OH- O – O – O 2N N N+ N N+ N - H2O O O 4 4 – 4 R R R – ² ³ – 2 2 2 R R R O O O N N N – NO 2 O – CH2 CH CH N+ 1 + OH- 1 O 2N 1 – R N R N R N O – - H2O O N+ 4 4 4 R R R O –  H3C H O H O O N N N OH N Cl N O 2N N Cl Diazepam Oxazepam Nitrazepam H O H3C H O O N N N O 2N N N Br N O 2N Cl F N Clonazepam Flunitrazepam Bromazepam H O Metabolismus von N Diazepam Cl N H3C H O O N N Desmethyldiazepam (Nordazepam) OH N Cl N Cl H3C O N OH Diazepam Cl N Oxazepam Temazepam  O - H3C O –  O - O ° HOOC HOOC CH3 KMnO4 HO COOH O O - CO2 - 2 CO2 CH3 HOOC HOOC ² ²  - - HOOC COO + COO + NH4 NH4 + 2 NH3 HO COOH - 3 H2O HOOC O N O HO N OH H H3C H3C H3C Ox. COOH COOH H HO O - CO2 O  - HO COO - O OC OH ² ² ²  ² ³ · HO COOH HO COOH HO COOH ·OH ·OH HC CH HC C C C HOOC OH - H2O HOOC OH - H2O HOOC OH ² OH OH HO OH O HO + + OH O OH OH O O Br Br KBr + Br OH Br O H2SO4 OH OH Ox. H2O HO HO Br - H3O + Br O O Br Br O O  - COO - COO ² ² ³ ² ² ³ ² ² ° COOH Zn/HCl CHO COOH COOH C 6H 5 CHO C6 H5 N NH COOH + H 2N NH C6 H5 - H 2O COOH N N + - H+ H N N H 2N NH K3[Fe(CN) 6 ] N N+ - CO 2 C6 H5 C 6H 5 C 6 H5  - COO OH ° O OH + 4 Br2 Br Br COOH - 4 HBr - CO2 Br Br ³ OH OH OH O 2N COOH O 2N NO 2 COOH HNO3 HNO3 - CO2 NO 2 NO 2  - SO 3 CH3