Uric Acid PDF

 Uric Acid Uric acid is formed from the breakdown of nucleic acids and is an end product of purine metabolism. Uric acid is transported by the plasma from the liver to the kidney, where it is filtered and where about 70% is excreted in Urine. The remainder of uric...

 Uric Acid Uric acid is formed from the breakdown of nucleic acids and is an end product of purine metabolism. Uric acid is transported by the plasma from the liver to the kidney, where it is filtered and where about 70% is excreted in Urine. The remainder of uric acid is excreted into the GI tract. The reasons of hyperuricemia Produce too much uric acid (about 10% of cases) ‫…يجري التحميل‬ unable to excrect enough uric acid into the urine (about 90% of cases) 1-Produce too much uric acid About 10% of cases of gout are due to overproduction of uric acid. Uric acid is high in the blood and the urine. Some people overproduce uric acid due to a genetic abnormality Since cells contain DNA, and DNA contains purines, anything that increases the breakdown of cells in the body can lead to more uric acid For example, if a patient is receiving chemotherapy for a tumor Foods can also lead to overproduction of uric acid, such as meats and beans and beer, which contain high levels of purines. 2- unable to excrete enough uric acid into the urine (90%) The most common is a genetic defect in the kidney. ‫…يجري التحميل‬ A defect in excretion of uric acid can also occur due to medications, such as diuretics, low dose aspirin, or alcohol. Defective uric acid excretion also occurs in renal disease.  Definition Gout A syndrome caused by the inflammatory response due to deposition of monosodium urate crystals (MSU) in and around joints and soft tissues or crystallization of uric acid in the urinary tract.  A uric acid blood test is done for: Diagnosis of gout. Follow up the effect of therapy for gout Check to see if kidney stones may be caused by high uric acid levels in the body. Check uric acid levels in people who are undergoing chemotherapy or radiation therapy Serum Uric Acid: normal values range from 4.0 to 8.6 mg/dl in men to 3.0 to 5.9 mg/dl in women.  What Affects the Test Some medicines may increase the level of uric acid in the blood. These include diuretics, theophylline and low-dose aspirin The vitamin niacin, high doses of vitamin C, caffeine, and a substance found in chocolate and tea (theobromine) can cause uric acid levels to be inaccurately high. Excessive use of alcohol, a high-protein diet, or strenuous exercise can raise the level of uric acid in the blood.  Diagnostic tests 1- Synovial Fluid Aspiration: in acute gout MSU crystals are identified with the polarized light microscope. Needle shaped crystals of monosodium urate monohydrate that have been engulfed by neutrophils. Polarized microscopy, the crystals appear Needle shaped crystals that are yellow Urate crystal in urine analysis(envelope shaped)