Drugs Used in the Treatment of Gout PDF

Drugs used in the Treatment of Gout  Gout Gout is a metabolic disorder characterized by high levels of uric acid in the blood. Hyperuricemia can lead to deposition of sodium urate crystals in tissues, especially the joints and kidney. Hyperuricemia does not always lead...

Drugs used in the Treatment of Gout  Gout Gout is a metabolic disorder characterized by high levels of uric acid in the blood. Hyperuricemia can lead to deposition of sodium urate crystals in tissues, especially the joints and kidney. Hyperuricemia does not always lead to gout, but gout is always preceded by hyperuricemia. Sodium urate is the end product of purine metabolism in humans.  The deposition of urate crystals initiates an inflammatory process involving the infiltration of granulocytes that phagocytize the urate crystals This process generates oxygen metabolites, which damage tissues, resulting in the release of lysosomal enzymes that evoke an inflammatory response. In addition, there is increased production of lactate in the synovial tissues The resulting local decrease in pH fosters further deposition of urate crystals.  Gout The cause of hyperuricemia is an overproduction of uric acid relative to the patient's ability to excrete it. Most therapeutic strategies for gout involve lowering the uric acid level below the saturation point (