Penis Diseases PDF

# PENIS ## I. HYPOSPADIAS - Opening of urethra on inferior surface of penis - Due to failure of the urethral folds to close ## II. EPISPADIAS - Opening of urethra on superior surface of penis - Due to abnormal positioning of the genital tubercle - Associated with bladder exstrophy ## III. CONDYLO...

# PENIS ## I. HYPOSPADIAS - Opening of urethra on inferior surface of penis - Due to failure of the urethral folds to close ## II. EPISPADIAS - Opening of urethra on superior surface of penis - Due to abnormal positioning of the genital tubercle - Associated with bladder exstrophy ## III. CONDYLOMA ACUMINATUM - Benign warty growth on genital skin - Due to HPV type 6 or 11; characterized by koilocytic change (Fig. 14.1) ## IV. LYMPHOGRANULOMA VENEREUM - Necrotizing granulomatous inflammation of the inguinal lymphatics and lymph nodes - Sexually transmitted disease caused by *Chlamydia trachomatis* (serotypes L1-L3) - Eventually heals with fibrosis; perianal involvement may result in rectal stricture. ## V. SQUAMOUS CELL CARCINOMA - Malignant proliferation of squamous cells of penile skin ### Risk factors - High risk HPV (2/3 of cases) - Lack of circumcision - Foreskin acts as a nidus for inflammation and irritation if not properly maintained. ### Precursor in situ lesions - Bowen disease - in situ carcinoma of the penile shaft or scrotum that presents as leukoplakia - Erythroplasia of Queyrat - in situ carcinoma on the glans that presents as erythroplakia - Bowenoid papulosis - in situ carcinoma that presents as multiple reddish papules - Seen in younger patients (40s) relative to Bowen disease and erythroplasia of Queyrat - Does not progress to invasive carcinoma