Toxicology1_rev08 (1) YYY PDF

Benzene Asbestos © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com Coal Tar Pitch Formaldehyde Volatiles © BLN, Inc. www.BowenEHS.com © BLN, Inc....

Benzene Asbestos © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com Coal Tar Pitch Formaldehyde Volatiles © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com  Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Asbestosis Eyes Inhalation Acute Lymphocytic Eyes Skin absorption Leukemia Skin Ingestion Mesothelioma Respiratory system Acute Myeloid Leukemia Skin and/or eye contact Lung cancer Ingestion Respiratory system Chronic Myelogenous Skin and/or eye contact Leukemia Blood Myelodysplasia Central nervous system Non-Hodgkin's Bone marrow Lymphoma Secondary aplastic anemia Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information General industry Dyspnea Fiber Construction Interstitial fibrosis Particulate matter Benzene production Irritation of the eyes, skin, VOC (petrochemicals, nose, respiratory system Aromatic hydrocarbon Maritime Restricted pulmonary function petroleum refining, and Dizziness Custodial workers coke and coal chemical Headache Finger clubbing manufacturing) Nausea Irritated eyes Rubber tire Staggered gait manufacturing and Anorexia storage Lassitude © BLN, Inc. Dermatitis © BLN, Inc. Bone marrow depression Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Nasal cancer Eyes Inhalation Bladder cancer Respiratory system Skin and/or eye contact Contact dermatitis Respiratory system Skin and/or eye contact Lung cancer Skin Kidney cancer Bladder Skin cancer Kidneys Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information Embalming students Irritation of the eyes, VOC Carbon black production Dermatitis Hydrocarbon mixture Garment workers nose, throat, respiratory Aldehyde workers Bronchitis Health care professionals system Wildland firefighters and medical lab Lacrimation Petroleum tanker deck technicians Cough crews Wheezing © BLN, Inc. © BLN, Inc.  alpha- 4-Nitrobiphenyl Naphthylamine © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com Methyl Dichlorobenzidine Chloromethyl (and its salts) Ether © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com  Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Bladder tumors/cancer Bladder Inhalation Bladder cancer Bladder Skin absorption Blood Skin absorption Skin Ingestion Ingestion Skin and/or eye contact Skin and/or eye contact Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information Hazardous waste Headache Biphenyl Cigarette smokers Dermatitis 1-Naphthol workers (no longer man- Drowsiness Dye manufacturers Hemorrhagic cystitis ufactured in the US) Dizziness Farmers Dyspnea Dyspnea Ataxia Ataxia Methemoglobinemia Lassitude Hematuria Methemoglobinemia Dysuria Urinary burning Acute hemorrhagic © BLN, Inc. © BLN, Inc. cystitis Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Skin cancer Eyes Inhalation Liver cancer Bladder Skin absorption Lung cancer Skin Skin absorption Bladder cancer Liver Ingestion Respiratory system Ingestion Lung Skin and/or eye contact Skin and/or eye contact Skin Gastrointestinal tract Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information Ion exchange resin man- Irritation of the eyes, skin, Ether ufacture mucous membrane Dye manufacturers Skin sensitization Biphenyl Textile industry Pulmonary edema Pulmonary congestion Dermatitis Pneumonitis Headache Skin burns Dizziness Necrosis Caustic burns Cough Frequent urination Wheezing, pulmonary Dysuria congestion Hematuria Blood stained-sputum Gastrointestinal upset Weight loss © BLN, Inc. Upper respiratory © BLN, Inc. Bronchial secretions infection  beta- bis-Chloromethyl Naphthylamine Ether © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com 4-Aminodiphenyl Benzidine © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com  Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Lung cancer Eyes Inhalation Bladder cancer Bladder Skin absorption Skin Skin absorption Lung disease Skin Ingestion Respiratory system Ingestion Skin and/or eye contact Skin and/or eye contact Major Industries Symptoms Additional Information Shipyard employees Irritation of the eyes, skin, Ether Construction employees mucous membrane, respiratory system Major Industries Symptoms Additional Information Pulmonary congestion Dye manufacturers Dermatitis Amine Pulmonary edema Corneal damage Hemorrhagic cystitis Necrosis Dyspnea Decreased pulmonary Ataxia function Methemoglobinemia Cough Hematuria Dyspnea Dysuria Wheezing Blood-stained sputum © BLN, Inc. © BLN, Inc. Bronchial secretions Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Liver cancer Bladder Inhalation Bladder cancer Bladder Skin absorption Kidney cancer Skin Skin absorption Skin Ingestion Bladder cancer Kidneys Ingestion Skin and/or eye contact Liver Skin and/or eye contact Blood Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information Dye manufacturers Hematuria Biphenyl Cigarette smokers Headache Diphenyl Rubber manufacturers Secondary anemia from Rubber manufacturers Dizziness Cigarette smokers hemolysis Drowsiness Acute cystitis Dyspnea Acute liver disorders Ataxia Dermatitis Lassitude Painful, irregular urination Methemoglobinemia Urinary burning © BLN, Inc. Acute hemorrhagic © BLN, Inc. cystitis  beta- Ethyleneimine Propiolactone © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com 4-Dimethylaminoazo- 2- benzene Acetylaminofluorene © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com  Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Lung tumors Eyes Inhalation Liver tumors Kidneys Skin absorption Liver tumors Skin Skin absorption Skin tumors Skin Ingestion Secondary bronchial Respiratory system Ingestion Stomach tumors Lungs Skin and/or eye contact pneumonia Liver Skin and/or eye contact Eyes Kidneys Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information Paper manufacture Irritation of the eyes, skin, Aziridine Textile industry nose, throat Used as chemical Skin irritation, blistering, Lactone Nausea intermediate in organic burns Vomiting synthesis Corneal opacity Headache Used in sterilization of Frequent urination Dizziness some food and medical Dysuria products Pulmonary edema Hematuria Liver damage Kidney damage Eye burns © BLN, Inc. © BLN, Inc. Skin sensitization Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Liver tumors Liver Inhalation Liver tumors Skin Skin absorption Bladder tumors Bladder Skin absorption Bladder tumors Respiratory system Ingestion Lung tumors Kidneys Ingestion Liver Skin and/or eye contact Skin tumors Pancreas Skin and/or eye contact Kidneys Pancreatic tumors Skin Bladder Major Industries Symptoms Additional Information Coloring polish Enlarged liver Aromatic hydrocarbon Major Industries Symptoms Additional Information manufacturers Liver and/or kidney Mainly found in research Reduced function of liver, Aminofluorene Wax product disturbance and laboratory facilities kidneys, bladder, manufacturers Contact dermatitis pancreas Cough Wheezing Dyspnea Bloody sputum Bronchial secretions Frequent urination © BLN, Inc. Hematuria © BLN, Inc. Dysuria  N- Vinyl Chloride Nitrosodimethylamine © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com Lead Inorganic Arsenic © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com  Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Lung tumors Liver Inhalation Liver cancer Liver Skin absorption Kidney tumors Kidneys Skin, and/or eye contact Angiosarcoma of the liver Central nervous system Ingestion Liver tumors Lungs (liquid) Obstructive disease of Blood Skin and/or eye contact Nasal cavity tumors peripheral arteries Respiratory system Lymphatic system Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information Cosmetics Nausea Methylamine PVC Production Lassitude Alkene manufacturers Vomiting Abdominal pain Toiletry manufacturers Diarrhea Gastrointestinal bleeding Abdominal cramps Enlarged liver Headache Pallor or cyanosis of Fever extremities Enlarged liver Frostbite (liquid) Jaundice Decreased liver, kidney, © BLN, Inc. © BLN, Inc. pulmonary function Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Liver cancer Liver Inhalation Nerve damage Eyes Skin absorption Bladder cancer Kidneys Ingestion Brain disorders Gastrointestinal tract Skin and/or eye contact Kidney cancer Skin Skin and/or eye contact Blood disorders Central nervous system Ingestion Lung cancer Lungs Kidneys Lymphatic cancer Lymphatic system Blood Skin cancer Gingival tissue Major Industries Symptoms Additional Information Battery manufacturers Lassitude Heavy metal Major Industries Symptoms Additional Information Insomnia Metal products Facial pallor Metal smelters Ulceration of nasal Heavy metal Ammunition Anorexia, weight loss Farmers septum manufacturers Malnutrition Dermatitis Constipation Abdominal pain Gastrointestinal Colic disturbances Anemia Peripheral neuropathy Gingival lead line Respiratory irritation Tremor Paralysis of the wrist, Hyperpigmentation of ankles skin Encephalopathy © BLN, Inc. Kidney disease © BLN, Inc. Irritated eyes  Cadmium Dust Chromium (VI) © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com Coke Oven Cadmium Fume Emissions © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com  Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Lung cancer Blood Inhalation Prostatic cancer Respiratory system Ingestion Respiratory system Ingestion Lung cancer Kidneys Skin and/or eye contact Liver Prostate Kidneys Blood Eyes Skin Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information Battery manufacturers Pulmonary edema Heavy metal Welders Irritated respiratory Heavy metal Metal welding/soldering Dyspnea Cement plant employees system Cough Nasal septum perforation Chest tightness Liver Substernal pain Headache Kidney damage Chills Leukocytosis Muscle aches Leukopenia Nausea Eosinophilia Vomiting Eye injury Diarrhea Conjunctivitis Anosmia Skin ulcer Emphysema © BLN, Inc. Proteinuria © BLN, Inc. Sensitization dermatitis Mild anemia Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Prostatic cancer Respiratory system Inhalation Skin cancer Skin Lung cancer Kidneys Skin and/or eye contact Lung cancer Respiratory system Blood Kidney cancer Urinary system Bladder cancer Major Industries Symptoms Additional Information Battery manufacturers Pulmonary edema Heavy metal Metal welding/soldering Dyspnea Major Industries Symptoms Additional Information Cough Chest tightness Iron manufacturers Irritated eyes Hydrocarbon mixture Substernal pain Steel Irritated respiratory Headache manufacturers system Chills Plastic manufacturers Cough Muscle aches Nausea Dye manufacturers Dyspnea Vomiting Wheezing Diarrhea Emphysema Proteinuria Anosmia © BLN, Inc. © BLN, Inc. Mild anemia  1,2-dibromo-3- Cotton Dust chloropropane © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com Ethylene Oxide Acrylonitrile © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com  Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Byssinosis Cardiovascular system Inhalation Nasal cavity cancer Eyes Chronic bronchitis or Respiratory system Skin absorption Tongue cancer Skin emphysema Ingestion Pharynx cancer Respiratory system Skin and/or eye contact Lungs cancer Central nervous system Liver Stomach cancer Kidneys Adrenal gland cancer Spleen Mammary gland cancer Reproductive system Digestive system Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information Cotton processing plants: Chest tightness Particulate slashing, weaving, Cough Farmers Irritated eyes, skin, nose, Halogenated hydrocarbon knitting, waste house Wheezing 1,2-dibromo-3- throat operations Dyspnea chloropropane Drowsiness Decreased forced Manufacturers Nausea expiratory volume Malaise Vomiting Fever Pulmonary edema Chills Liver Upper respiratory Kidney injury symptoms after initial © BLN, Inc. Sterility © BLN, Inc. exposure Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Brain tumors Eyes Inhalation Peritoneal cancer Eyes Skin absorption Lung cancer Skin Ingestion (liquid) Leukemia Skin Respiratory system Ingestion Bowel cancer Cardiovascular system Skin and/or eye contact Liver Skin and/or eye contact Liver Central nervous system Kidneys Blood Central nervous system Kidneys Reproductive system Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information Food spice manufacture Irritated eyes, skin, nose, Alkene throat Irritated eyes, skin Peculiar taste Plastic manufacturers Acrylic acid Headache Synthetic rubber Asphyxia Acrolein Nausea manufacturers Headache Vomiting Synthetic polymer Sneezing Diarrhea manufacturers Nausea Dyspnea Cyanosis Vomiting Pulmonary edema Lassitude Drowsiness Dizziness Lassitude Skin vesiculation Incoordination © BLN, Inc. EKG abnormalities © BLN, Inc. Scaling dermatitis Eye, skin burns  1,3-Butadiene 4,4' - Methylenedianiline © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com Silica (crystalline) Methylene Chloride © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com  Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Bladder cancer Eyes Inhalation Hematopoietic cancer Eyes Skin absorption Liver Skin and/or eye contact Respiratory system Ingestion Cardiovascular system (liquid) Central nervous system Skin and/or eye contact Spleen Reproductive system Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information Polyurthane foam Irritated eyes Alkene Synthetic rubber Irritated eyes, nose, Butane manufactures Jaundice manufacturers throat Hepatitis Acrylic manufacturers Drowsiness Myocardial damage Petroleum manufacturers Dizziness In animals: heart, liver, Frostbite (liquid) spleen damage Teratogenic, reproductive effects © BLN, Inc. © BLN, Inc. Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Lung tumors Eyes Inhalation Silicosis Eyes Skin absorption Liver tumors Skin Skin and/or eye contact Respiratory system Ingestion Salivary gland tumors Cardiovascular system Skin and/or eye contact Mammary gland tumors Central nervous system Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information Construction Irritated eyes, skin Halogenated hydrocarbon Construction Cough Particulate Coffee manufacturers Lassitude Roofers Dyspnea Garment printers Drowsiness Rock drillers Wheezing Dizziness Decreased pulmonary Numbness function Tingling limbs Progressive respiratory symptoms Nausea Irritated eyes © BLN, Inc. © BLN, Inc.  Hydrofluoric Acid Phosgene (hydrogen flouride) © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com Carbon Monoxide Nitric Acid © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com  Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Chronic bronchitis Eyes Inhalation Hemorrhagic pulmonary Eyes Skin and/or eye contact Emphysema Skin Skin absorbtion (liquid) edema Skin Pneumonia Respiratory system Ingestion (solution) Respiratory system Skin and/or eye contact Bones Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information Plastic manufacturers Irritated eyes Aldehyde Chemical manufacturers Irritated eyes, skin, nose, Acute toxicity Farmers Dry, burning throat Metallurgical industry throat Burns may appear several Vomiting Glass manufacturers Pulmonary edema hours after exposure Cough Eye, skin burns Foamy sputum Rhinitis Dyspnea Bronchitis Chest pain Bone changes Cyanosis Frostbite (liquid) © BLN, Inc. © BLN, Inc. Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Stomatitis Eyes Inhalation Anoxia Cardiovascular system Ingestion Delayed pulmonary ede- Skin Skin and/or eye contact Lungs Skin and/or eye contact ma Respiratory system (liquid) Blood Dental erosion Teeth Central nervous system Major Industries Symptoms Additional Information Major Industries Symptoms Additional Information Iron manufacturers Headache Toxic gas Meat packing industry Tachypnea Oxide Dye manufacturers Irritated eyes, skin, Acid mucous membrane Mining industry Nausea Farmers Oxidizer Pneumonitis Lassutude Textile manufacturers Bronchitis Dizziness Confusion Hallucinations Cyanosis Depressed S-T segment of electrocardiogram © BLN, Inc. Angina © BLN, Inc.  Picric Acid Portland Cement © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com Ozone Parathion © BLN, Inc. www.BowenEHS.com © BLN, Inc. www.BowenEHS.com  Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Chronic bronchitis Eyes Inhalation Kidney damage Eyes Ingestion Dermatitis Skin Skin absorption Liver damage Skin Skin and/or eye contact Respiratory system Ingestion Kidneys Skin and/or eye contact Liver Blood Major Industries Symptoms Additional Information Fireworks manufacturers Irritated eyes, skin Highly explosive phenol Major Industries Symptoms Additional Information Electric battery Sensitization dermatitis manufacturers Yellow-stained hair, skin Construction workers Irritated eyes, skin, nose Particulate dust composed Disinfectant Lassitude Road workers Cough of mineral mixture manufacturers Myalgia Expectoration Anuria Exertional dyspnea Polyuria Wheezing Bitter taste Gastrointestional Chronic bronchitis disturbance Dermatitis Hepatitis Hematuria © BLN, Inc. Albuminuria © BLN, Inc. Nephritis Routes of Exposure Disease(s) Target Organs Routes of Exposure Disease(s) Target Organs Inhalation Hyperkeritinization Eyes Inhalation Bronchitis Eyes Skin absorption Skin Skin and/or eye contact Bronchiolitis Respiratory system Ingestion Respiratory system Fibrosis Skin and/or eye contact Central nervous system Emphysematous Cardiovascular system Blood cholinesterase Major Industries Symptoms Additional Information Farmers Irritated eyes, skin, Pesticide respiratory system Major Industries Symptoms Additional Information Pesticide manufacturers Miosis Cholinesterase inhibitor Rhinorrhea Aromatic hydrocarbon Welders Irritated eyes, mucous Lower respiratory irritant Headache Industrial waste membrane Chest tightness treatment workers Pulmonary edema Wheezing Laryngeal spasm Cold storage workers Chronic respiratory Salivation disease Cyanosis Anorexia Nausea, vomiting, abdominal cramps, diarrhea Sweating © BLN, Inc. © BLN, Inc. Muscle fasciculation