The Female Reproductive System PDF

**[THE FEMALE REPRODUCTIVE SYSTEM]** The female reproductive system includes all of the internal and external organs that help with reproduction. The internal sex organs are: - **[the ovaries]**, which are the female gonads - **[the fallopian tubes]**, two muscular tubes that connect the...

**[THE FEMALE REPRODUCTIVE SYSTEM]** The female reproductive system includes all of the internal and external organs that help with reproduction. The internal sex organs are: - **[the ovaries]**, which are the female gonads - **[the fallopian tubes]**, two muscular tubes that connect the ovaries to the uterus - and **[the uterus]**, which is the strong muscular sack that a fetus can develop in. - The neck of the uterus is called **[the cervix]**, and it protrudes into the vagina. At the opening of the vagina are the external sex organs, and these are usually just called the genitals and they're in **[the vulva region]**. They include the: - Labia - the clitoris - and the mons pubis. The ovaries are a pair of white-ish organs about the size of walnuts. They're held in place, slightly above and on either side of the uterus and fallopian tubes by ligaments. Specifically, there's: - the broad ligament - the ovarian ligament - and the suspensory ligament. - the ovarian artery - ovarian vein - and ovarian nerve plexus - [there's an outer layer called **the cortex**], which has ovarian follicles scattered throughout it - [and an inner layer called **the medulla**], which contains most of the blood vessels and nerves. At birth, the ovarian cortex has **[around two million follicles]** and they're called **[primordial follicles]**. - Each primordial follicle has [a single immature sex cell called **the primary oocyte** at the core], and [a layer of **follicular cells** surrounds this]. - The primary oocyte [has **46 chromosomes**] - but eventually [it has to turn into a **gamete** with only **23 chromosomes**]. - To do this, [the primary oocytes have to complete **meiosis 1**] - and in a person's lifetime only about **400** successfully do that. - [This process of **oocyte development** follows that of **follicular development**], which can be broken into **[three stages]**. 1. The first stage lasts from **[infancy to puberty]** - during this stage [the primary oocyte remains stuck in **the prophase** step of **meiosis** 1]. - Meaning, the cell is living, but not dividing. - Meanwhile, **[the primordial follicle turns into a primary follicle]**, meaning that [the follicular cells that surround the primary oocyte **develop into granulosa cells**]. 2. The second stage of **[follicular development]** - begins for **[a few lucky primary follicles]** with the first menstrual cycle in puberty, and [a few more primary follicles go into the second stage with each subsequent menstrual cycle]. - In the second stage, [**the primary follicles** develop into **secondary** and eventually **tertiary**, or **graafian follicles**]. - In a secondary follicle, [the primary oocyte is still in the prophase step of meiosis 1], but now [the follicle has additional layers of **granulosa cells**], as well as **[theca cells]**. - [**Theca cells** make **androstenedione**], a sex hormone precursor, - and [**granulosa cells** use the enzyme **aromatase** to convert it into **estradiol**] - a member of the estrogen family, [as well as **progesterone**]. [In a graafian follicle, a central cavity called **the antrum** forms within the follicle, and **the granulosa cells** secrete a **nourishing fluid** for the primary oocyte directly into that antrum]. - The second stage [takes roughly **70 to 85 days**] and results in a [few **fast-growing graafian follicles**]. 3. The third stage of follicular development starts when the graafian follicles are ready and [occurs during **the follicular phase of the menstrual cycle**]. Let's go over the highlights of the menstrual cycle to put that follicular phase into context. The menstrual cycle starts on: - the first day of menstrual bleeding - lasts 28 days on average from then. Assuming a 28-day cycle: - **[the follicular phase]** [makes up the first two weeks of the menstrual cycle] - and [**the luteal phase**, the last two weeks]. These two phases are [separated by **ovulation**], which is when - The menstrual cycle is ultimately controlled by the hypothalamus, which is at the base of the brain. - **[Before puberty]** - the hypothalamus **constantly secretes** small amounts of a hormone called **[gonadotropin-releasing hormone]**, or **[GnRH]**. - That GnRH travels to the nearby pituitary, which secretes two hormones of its own - **[follicle stimulating hormone]**, or **FSH** - and **[luteinizing hormone]**, or **LH**. - **[Once puberty hits]** - the hypothalamus starts to **[secrete GnRH in pulses]**, sometimes more and sometimes less - and pituitary **[FSH]** and **[LH]** **[make the ovarian follicles develop.]** - The amount of GnRH can be mapped out like a wave over time - and the frequency and amplitude of the waves of GnRH determine how much FSH and LH get produced by the pituitary. - [**LH** binds to **LH receptors** on **theca cells**], making them secrete **[androstenedione]**. - [**FSH** binds to **FSH receptors** on **granulosa cells** and they make **aromatase** and, as a consequence, **estrogen**]. - Serum levels of estrogen and progesterone act as feedback for the command center in the brain, which adjusts its hormone production according to the phases of the menstrual cycle. - During the follicular phase of each menstrual cycle, the few fast-growing graafian follicles enter the third stage of development. - Pituitary FSH **[makes the follicles grow]** and **[the granulosa cells produce more estrogen]**. - In addition to estrogen[, the granulosa cells **also secrete a hormone called activin**, which stimulates FSH production] - as well as binding to FSH receptors - and the activity of granulosa cell aromatase as well. - However, estrogen acts as a negative feedback signal - it tells the pituitary to secrete less FSH and LH. - Less FSH means that **[there is only enough left to stimulate one follicle]**. - The follicle that has the most FSH receptors hoards most of this hormone, and becomes the dominant follicle. - It usually takes about a week for a dominant follicle to get selected, and after that happens, **[the rest of the follicles regress and die off]**. - The dominant follicle keeps secreting estrogen for the rest of the follicular phase. - The steady increase in estrogen makes the pituitary more responsive to the pulsatile action of hypothalamic GnRH. - When blood estrogen levels [reach **200 picograms/milliliter**]dominant follicle estrogen becomes a positive feedback signal - it makes the pituitary secrete a whole lot of **FSH** and **LH** in response to GnRH. - This triggers the primary oocyte within the dominant follicle to **[finally complete meiosis 1]**, and turn into **[a secondary oocyte]**, which has **[23 chromosomes]**. - [The dominant follicle completes its **third stage of development** in a blaze of glory called **ovulation**]. - That's when the nearly 2 centimeter sized follicle ruptures and releases the tiny secondary oocyte into the fallopian tube. - The secondary oocyte stops in **[metaphase of meiosis 2]**, and **[waits for fertilization]** as [the menstrual cycle transitions into **the luteal phase**]. **[The luteal phase]** makes up the second half of the menstrual cycle - week 3 and week 4, of the 4-week cycle. - Right after ovulation, while the LH levels are still high, **[the remains of the follicle turn into the corpus luteum]**, which is made up of - luteinized granulosa - and theca cells. - [Luteinized granulosa cells secrete **inhibin**] - which inhibits the pituitary gland from making FSH. - [Without FSH, **estrogen levels fall**, and the amount of **LH** goes back to the level before ovulation]. - **[Luteinized theca]** cells [keep secreting **androstenedione**] - and **[the luteinized granulosa]** cells keep converting it to **[17β-estradiol]**, as before. - However, luteinized granulosa cells also **[respond to the low luteinizing hormone concentrations that are present after ovulation]** by increasing the activity of **[cholesterol side-chain cleavage enzyme]**, or **[P450scc]** for short. - This enzyme converts more cholesterol to **[pregnenolone]**, **[a progesterone precursor]**. - So luteinized granulosa cells **[secrete more progesterone]** than estrogen during **[the luteal phase]**. - So, overall, this means that **[progesterone surpasses estrogen as the dominant hormone during the luteal phase of the menstrual cycle]**. - **[If fertilization occurs]** - meaning if a sperm meets the secondary oocyte - then the corpus luteum **[continues making progesterone]** until the placenta forms. - **[If fertilization doesn't happen]** - then the corpus luteum **[stops making hormones]** after around 10 days, becomes fibrotic, and is called **[the corpus albicans]**. **[After ovulation]** - the secondary oocyte makes a very quick journey [through **the peritoneal space**] and [lands in the fallopian tube]. - [The first part is **the fimbriae**] which are the finger-like projections that surround the ovary and [guide the secondary oocyte into the fallopian tube]. - Next is the **[infundibulum]** and then **[the ampullary region]** which is **[where fertilization typically happens]** between the secondary oocyte and the sperm - this is the magical spot where they meet. which curves around the ovary - and finally **[the isthmus region]**, which opens into the uterine cavity. - On the outside, the fallopian tubes are covered by peritoneum, and supported by the mesosalpinx, which is part of the broad ligament. - On the inside, the fallopian tubes have [smooth muscle with an inner lining that has ciliated cells that **slowly sweep the secondary oocyte or zygote** towards **the uterus**]**.** **[The uterus]** is a hollow organ that sits behind the urinary bladder and in front of the rectum. - The top of the uterus above the openings of the fallopian tubes is called **[the fundus]**, - and the region below the openings is called **[the uterine body]**. - The uterus tapers down into [the uterine isthmus] and finally **[the cervix]**, which protrudes into the vagina. **[The cervix]** has a superior opening up top, and an inferior opening down below - both of which have mucus plugs to keep the uterus closed off except: - **[during menstruation ]** - and **[right before ovulation]** to allow sperm to reach the secondary oocyte. - The uterus is anchored to the sacrum by **[uterosacral ligaments]**, to the anterior body wall by **[round ligaments]**, and it's supported laterally by **[cardinal ligaments]** as well as **[the mesometrium]**, which is part of the broad ligament. The wall of the uterus has three layers: - **[the perimetrium]**, which is a layer continuous with the lining of the peritoneal cavity, - **[the myometrium]**, which is made of smooth muscle that contracts during childbirth to help push the baby out - and **[the endometrium]**, a mucosal layer, that undergoes monthly cyclic changes. During **[the follicular phase of the menstrual cycle]** - the endometrium thickens in case fertilization occurs - during the luteal phase, spiral arteries emerge to bring more nutrients to support the thick endometrium. - [If fertilization doesn't occur, **the spiral arteries collapse**], and **[the superficial layers of the endometrium die]**. - During menstruation or menstrual bleeding, that dead tissue is removed or sloughed off of the uterus through the vagina. **[The vagina]** has a muscular wall and is covered by an inner mucosa with ridges that run along it. - The vagina is the passageway for the baby during childbirth, and it opens up into the vulva. - In childhood, [a thin sheet of vaginal mucosa called **the hymen** partially covers the vaginal opening], and it can break because of - Exercise - the use of tampons - or sexual intercourse. The external sex organs, together referred to as **[the vulva]**, are - **[the labia majora]** which are called "the two greater lips" - **[labia minora]**, or "the two smaller lips" - **[the mons pubis]**, or "the mountain of the pubis" - and **[the clitoris]**, a small erectile organ that develops from the same embryonic tissue as the male penis. It is hooded by a skin fold called the clitoral hood. - The labia majora cover the labia minora, and between the two labia minora there is a space called **[the vulvar vestibule]** that includes - the opening of the vagina - and the urethral opening. Quick review: 1. the female reproductive system comprises of internal sex organs, such as the ovaries, the fallopian tubes, the uterus and the vagina, as well as external sex organs such as the labia, the mons pubis and the clitoris. 2. The ovaries are the female gonads, and they produce the ova, as well as the female sex hormones. 3. Both the ovaries and the uterus are subject to the pulsatile hormonal activity of the hypothalamus and pituitary glands. 4. The uterus is where pregnancy develops, and the baby comes into the world through the birth canal, or the vagina, that connects the internal and external sex organs.