Techno 4 Final Exam PDF

## Choose the most Appropriate Option **Each question carries 2.5 marks.** ### Attempt All Questions 1. All but one of the following is an example of a solid dosage form: - (a) powders - (b) liniment - (c) granules - (d) tablets 2. Granules are prepared because of the following re...

## Choose the most Appropriate Option **Each question carries 2.5 marks.** ### Attempt All Questions 1. All but one of the following is an example of a solid dosage form: - (a) powders - (b) liniment - (c) granules - (d) tablets 2. Granules are prepared because of the following reasons except: - (a) to improve the flow of powders - (b) to enhance powder segregation - (c) to improve the compressibility of powders into tablets - (d) all of the above 3. An increase in particle size leads to a corresponding increase in the surface area of the particles. - (a) True - (b) False 4. The particle size of a drug does not affect its release from dosage forms that are administered orally, parenterally, rectally and topically. - (a) True - (b) False 5. A Carr's index values of 12% signifies: - (a) good compressibility - (b) excellent compressibility - (c) fair compressibility - (d) poor compressibility 6. An angle of repose values of 26° signifies: - (a) excellent compressibility - (b) good compressibility - (c) fair compressibility - (d) poor compressibility 7. All but one of the following are the mechanisms of action of disintegrants in tablets: - (a) swelling - (b) capillary action - (c) diffusion - (d) wicking 8. The hardness of a tablet depends on: - (a) compression force - (b) concentration of the binding agent - (c) type of the binding agent - (d) all of the above 9. The percentage of weight loss of powder from the surface of the tablets due to mechanical action is called: - (a) hardness - (b) friability - (c) disintegration - (d) all of the above 10. The official tests of tablets include all but one of the following: - (a) weight variation - (b) dissolution - (c) content uniformity - (d) size and shape 11. Disintegrants are incorporated into tablets: - (a) intragranularly - (b) extragranularly - (c) intra-extragranularly - (d) all of the above 12. Lubricants: - (a) prevent adhesion of the tablet materials to the surface of the dies and punches - (b) reduce inter particle friction - (c) facilitate the ejection of the tablets from the die cavity - (d) all of the above 13. All but one of the following are types of mixture: - (a) positive mixture - (b) natural mixture - (c) negative mixture - (d) neutral mixture 14. All but one of the following are the main objectives of mixing: - (a) To promote chemical reaction to get uniform products - (b) Dispersion of solid in liquid to form suspension or paste - (c) Dispersion of two immiscible liquids to form an emulsion - (d) none of the above 15. Which of the following is a method used in the preparation of granules: - (a) dry granulation - (b) wet granulation - (c) melt granulation - (d) all of the above 16. The science and technology of small particles is called: - (a) micrometrics - (b) micromeritics - (c) micrometer - (d) all of the above 17. An increase in particle size leads to a corresponding increase in the surface area of the particles - (a) True - (b) False 18. The particle size of a drug does not affect its release from dosage forms that are administered orally, parenterally, rectally and topically. - (a) True - (b) False 19. The flow and compressibility of powders can be measured by the following methods except: - (a) angle of repose - (b) Carr's index - (c) Hausner ratio - (d) angle of elevation 20. A Carr's index values of 8% signifies: - (a) good compressibility - (b) excellent compressibility - (c) fair compressibility - (d) poor compressibility 21. An angle of repose values of 32° signifies: - (a) excellent compressibility - (b) good compressibility - (c) fair compressibility - (d) poor compressibility 22. Granules are prepared because of the following reasons except: - (a) to improve the flow of powders - (b) to enhance powder segregation - (c) to improve the compressibility of powders into tablets - (d) all of the above 23. All but one of the following methods is used in determining the particle size of powders: - (a) optical microscopy - (b) Viscometer - (c) sieving - (d) sedimentation 24. The factors affecting the mixing of powders include all but one of the following: - (a) particle size - (b) particle shape - (c) viscosity of the powders - (d) density of the powders 25. Powders are more stable to atmospheric conditions compared to granules. - (a) True - (b) False 26. The temperature and pressure at which a substance can exist in equilibrium in the liquid, solid, and gaseous states is called: - (a) triple temperature - (b) triple pressure - (c) triple point - (d) all of the above 27. The point at which a solid is sublimed is known as: - (a) eutectic point - (b) eutectic point - (c) point - (d) all of the above 28. All but one of the following are the advantages of freeze drying: - (a) Minimum damage and loss of activity in delicate heat-liable materials - (b) Speed and completeness of rehydration - (c) Drying takes place at very low temperatures, so that enzyme action is activated and decomposition particularly hydrolysis is minimized - (d) formation of porous and friable structure 29. All but one of the following are the disadvantages of freeze drying: - (a) High capital cost of equipment - (b) High energy cost - (c) Short processing time - (d) Very expensive 30. Lyophilization should be used when the product meets all but one of the following criteria: - (a) Heat stable - (b) Accurate dosing is needed - (c) Quick and complete rehydration is needed - (d) High value 31. Freeze drying is used to dry all but one of the following products: - (a) hormones - (b) vaccine - (c) soft gelatin capsules - (d) plasma 32. All but one of the following are the purposes of drying: - (a) to eliminate moisture from the drug - (b) to improve the stability of the drug - (c) to reduce the flowability of granules - (d) to reduce the cost of transportation of large volume materials. 33. Lyophilization is also known as all but one of the following: - (a) freeze drying - (b) gelsication - (c) drying by sublimation - (d) gelsicsation 34. Sublimation occurs when: - (a) a liquid is converted to gas - (b) a gas is converted to a solid - (c) a solid is converted to a gas - (d) a gas is converted to a liquid 35. In freeze drying, the product to be dried is first frozen and then subjected to drying under high vacuum through condensation. - (a) true - (b) false 36. All but one of the following are the steps involved in the manufacture of gelatin capsule shell: - (a) dipping - (b) spinning - (c) smoothening - (d) stripping 37. All but one of the following are the benefits of soft gelatin capsules: - (a) increase the rate of drug absorption - (b) improve patient adherence - (c) improve manufacturability of low melting point and high dose drugs - (d) improve manufacturing safety for potent and cytotoxic drugs. 38. Capsules that are used to enclose liquids, oils and semi-solids are called: - (a) hard gelatin capsules - (b) soft gelatin capsules - (c) softgels - (d) b and c