TCA Cycle and HMP Shunt: 100-MCQ Exam PDF

TCA Cycle and HMP Shunt: 100-MCQ Exam This exam is designed to test your knowledge of the TCA Cycle and HMP Shunt, including their roles, regulation, clinical relevance, and associated metabolic pathways. Answer each question by selecting the best option. 1. Where does the TCA cycle occur? A)...

TCA Cycle and HMP Shunt: 100-MCQ Exam This exam is designed to test your knowledge of the TCA Cycle and HMP Shunt, including their roles, regulation, clinical relevance, and associated metabolic pathways. Answer each question by selecting the best option. 1. Where does the TCA cycle occur? A) Cytosol B) Mitochondria C) Nucleus D) Endoplasmic Reticulum Correct Answer: B 2. Which enzyme converts Pyruvate to Acetyl CoA? A) Citrate Synthase B) Pyruvate Dehydrogenase Complex (PDH) C) Isocitrate Dehydrogenase D) Lactate Dehydrogenase Correct Answer: B 3. Which condition is caused by thiamine deficiency affecting the PDH complex? A) Congenital Lactic Acidosis B) Wernicke's Encephalopathy C) Arsenic Poisoning D) Favism Correct Answer: B 4. How many ATP molecules are produced directly in one TCA cycle? A) 1  B) 2 C) 3 D) 4 Correct Answer: A 5. What inhibits the enzyme Citrate Synthase? A) ATP B) ADP C) NAD+ D) FAD Correct Answer: A 6. Which molecule is NOT produced in the HMP pathway? A) ATP B) NADPH C) Ribose-5-Phosphate D) CO2 Correct Answer: A 7. What is the primary regulatory enzyme of the HMP Shunt? A) Citrate Synthase B) Glucose-6-Phosphate Dehydrogenase (G6PD) C) Pyruvate Kinase D) Transketolase Correct Answer: B 8. Which of the following tissues has high HMP activity due to fatty acid synthesis? A) Muscle B) Liver  C) Brain D) Skin Correct Answer: B 9. What is the role of NADPH in erythrocytes? A) Protein synthesis B) Reduction of glutathione C) Glycolysis D) DNA synthesis Correct Answer: B 10. Which drug is NOT an oxidant drug causing hemolysis in G6PD deficiency? A) Primaquine B) Quinine C) Sulfamethoxazole D) Acetanilid Correct Answer: B 11. Where does the TCA cycle occur? A) Cytosol B) Mitochondria C) Nucleus D) Endoplasmic Reticulum Correct Answer: B 12. Which enzyme converts Pyruvate to Acetyl CoA? A) Citrate Synthase B) Pyruvate Dehydrogenase Complex (PDH) C) Isocitrate Dehydrogenase  D) Lactate Dehydrogenase Correct Answer: B 13. Which condition is caused by thiamine deficiency affecting the PDH complex? A) Congenital Lactic Acidosis B) Wernicke's Encephalopathy C) Arsenic Poisoning D) Favism Correct Answer: B 14. How many ATP molecules are produced directly in one TCA cycle? A) 1 B) 2 C) 3 D) 4 Correct Answer: A 15. What inhibits the enzyme Citrate Synthase? A) ATP B) ADP C) NAD+ D) FAD Correct Answer: A 16. Which molecule is NOT produced in the HMP pathway? A) ATP B) NADPH C) Ribose-5-Phosphate D) CO2  Correct Answer: A 17. What is the primary regulatory enzyme of the HMP Shunt? A) Citrate Synthase B) Glucose-6-Phosphate Dehydrogenase (G6PD) C) Pyruvate Kinase D) Transketolase Correct Answer: B 18. Which of the following tissues has high HMP activity due to fatty acid synthesis? A) Muscle B) Liver C) Brain D) Skin Correct Answer: B 19. What is the role of NADPH in erythrocytes? A) Protein synthesis B) Reduction of glutathione C) Glycolysis D) DNA synthesis Correct Answer: B 20. Which drug is NOT an oxidant drug causing hemolysis in G6PD deficiency? A) Primaquine B) Quinine C) Sulfamethoxazole D) Acetanilid Correct Answer: B 21. Where does the TCA cycle occur? A) Cytosol B) Mitochondria C) Nucleus D) Endoplasmic Reticulum Correct Answer: B 22. Which enzyme converts Pyruvate to Acetyl CoA? A) Citrate Synthase B) Pyruvate Dehydrogenase Complex (PDH) C) Isocitrate Dehydrogenase D) Lactate Dehydrogenase Correct Answer: B 23. Which condition is caused by thiamine deficiency affecting the PDH complex? A) Congenital Lactic Acidosis B) Wernicke's Encephalopathy C) Arsenic Poisoning D) Favism Correct Answer: B 24. How many ATP molecules are produced directly in one TCA cycle? A) 1 B) 2 C) 3 D) 4 Correct Answer: A 25. What inhibits the enzyme Citrate Synthase?  A) ATP B) ADP C) NAD+ D) FAD Correct Answer: A 26. Which molecule is NOT produced in the HMP pathway? A) ATP B) NADPH C) Ribose-5-Phosphate D) CO2 Correct Answer: A 27. What is the primary regulatory enzyme of the HMP Shunt? A) Citrate Synthase B) Glucose-6-Phosphate Dehydrogenase (G6PD) C) Pyruvate Kinase D) Transketolase Correct Answer: B 28. Which of the following tissues has high HMP activity due to fatty acid synthesis? A) Muscle B) Liver C) Brain D) Skin Correct Answer: B 29. What is the role of NADPH in erythrocytes? A) Protein synthesis  B) Reduction of glutathione C) Glycolysis D) DNA synthesis Correct Answer: B 30. Which drug is NOT an oxidant drug causing hemolysis in G6PD deficiency? A) Primaquine B) Quinine C) Sulfamethoxazole D) Acetanilid Correct Answer: B 31. Where does the TCA cycle occur? A) Cytosol B) Mitochondria C) Nucleus D) Endoplasmic Reticulum Correct Answer: B 32. Which enzyme converts Pyruvate to Acetyl CoA? A) Citrate Synthase B) Pyruvate Dehydrogenase Complex (PDH) C) Isocitrate Dehydrogenase D) Lactate Dehydrogenase Correct Answer: B 33. Which condition is caused by thiamine deficiency affecting the PDH complex? A) Congenital Lactic Acidosis B) Wernicke's Encephalopathy  C) Arsenic Poisoning D) Favism Correct Answer: B 34. How many ATP molecules are produced directly in one TCA cycle? A) 1 B) 2 C) 3 D) 4 Correct Answer: A 35. What inhibits the enzyme Citrate Synthase? A) ATP B) ADP C) NAD+ D) FAD Correct Answer: A 36. Which molecule is NOT produced in the HMP pathway? A) ATP B) NADPH C) Ribose-5-Phosphate D) CO2 Correct Answer: A 37. What is the primary regulatory enzyme of the HMP Shunt? A) Citrate Synthase B) Glucose-6-Phosphate Dehydrogenase (G6PD) C) Pyruvate Kinase  D) Transketolase Correct Answer: B 38. Which of the following tissues has high HMP activity due to fatty acid synthesis? A) Muscle B) Liver C) Brain D) Skin Correct Answer: B 39. What is the role of NADPH in erythrocytes? A) Protein synthesis B) Reduction of glutathione C) Glycolysis D) DNA synthesis Correct Answer: B 40. Which drug is NOT an oxidant drug causing hemolysis in G6PD deficiency? A) Primaquine B) Quinine C) Sulfamethoxazole D) Acetanilid Correct Answer: B 41. Where does the TCA cycle occur? A) Cytosol B) Mitochondria C) Nucleus D) Endoplasmic Reticulum  Correct Answer: B 42. Which enzyme converts Pyruvate to Acetyl CoA? A) Citrate Synthase B) Pyruvate Dehydrogenase Complex (PDH) C) Isocitrate Dehydrogenase D) Lactate Dehydrogenase Correct Answer: B 43. Which condition is caused by thiamine deficiency affecting the PDH complex? A) Congenital Lactic Acidosis B) Wernicke's Encephalopathy C) Arsenic Poisoning D) Favism Correct Answer: B 44. How many ATP molecules are produced directly in one TCA cycle? A) 1 B) 2 C) 3 D) 4 Correct Answer: A 45. What inhibits the enzyme Citrate Synthase? A) ATP B) ADP C) NAD+ D) FAD Correct Answer: A 46. Which molecule is NOT produced in the HMP pathway? A) ATP B) NADPH C) Ribose-5-Phosphate D) CO2 Correct Answer: A 47. What is the primary regulatory enzyme of the HMP Shunt? A) Citrate Synthase B) Glucose-6-Phosphate Dehydrogenase (G6PD) C) Pyruvate Kinase D) Transketolase Correct Answer: B 48. Which of the following tissues has high HMP activity due to fatty acid synthesis? A) Muscle B) Liver C) Brain D) Skin Correct Answer: B 49. What is the role of NADPH in erythrocytes? A) Protein synthesis B) Reduction of glutathione C) Glycolysis D) DNA synthesis Correct Answer: B 50. Which drug is NOT an oxidant drug causing hemolysis in G6PD deficiency?  A) Primaquine B) Quinine C) Sulfamethoxazole D) Acetanilid Correct Answer: B 51. Where does the TCA cycle occur? A) Cytosol B) Mitochondria C) Nucleus D) Endoplasmic Reticulum Correct Answer: B 52. Which enzyme converts Pyruvate to Acetyl CoA? A) Citrate Synthase B) Pyruvate Dehydrogenase Complex (PDH) C) Isocitrate Dehydrogenase D) Lactate Dehydrogenase Correct Answer: B 53. Which condition is caused by thiamine deficiency affecting the PDH complex? A) Congenital Lactic Acidosis B) Wernicke's Encephalopathy C) Arsenic Poisoning D) Favism Correct Answer: B 54. How many ATP molecules are produced directly in one TCA cycle? A) 1  B) 2 C) 3 D) 4 Correct Answer: A 55. What inhibits the enzyme Citrate Synthase? A) ATP B) ADP C) NAD+ D) FAD Correct Answer: A 56. Which molecule is NOT produced in the HMP pathway? A) ATP B) NADPH C) Ribose-5-Phosphate D) CO2 Correct Answer: A 57. What is the primary regulatory enzyme of the HMP Shunt? A) Citrate Synthase B) Glucose-6-Phosphate Dehydrogenase (G6PD) C) Pyruvate Kinase D) Transketolase Correct Answer: B 58. Which of the following tissues has high HMP activity due to fatty acid synthesis? A) Muscle B) Liver  C) Brain D) Skin Correct Answer: B 59. What is the role of NADPH in erythrocytes? A) Protein synthesis B) Reduction of glutathione C) Glycolysis D) DNA synthesis Correct Answer: B 60. Which drug is NOT an oxidant drug causing hemolysis in G6PD deficiency? A) Primaquine B) Quinine C) Sulfamethoxazole D) Acetanilid Correct Answer: B 61. Where does the TCA cycle occur? A) Cytosol B) Mitochondria C) Nucleus D) Endoplasmic Reticulum Correct Answer: B 62. Which enzyme converts Pyruvate to Acetyl CoA? A) Citrate Synthase B) Pyruvate Dehydrogenase Complex (PDH) C) Isocitrate Dehydrogenase  D) Lactate Dehydrogenase Correct Answer: B 63. Which condition is caused by thiamine deficiency affecting the PDH complex? A) Congenital Lactic Acidosis B) Wernicke's Encephalopathy C) Arsenic Poisoning D) Favism Correct Answer: B 64. How many ATP molecules are produced directly in one TCA cycle? A) 1 B) 2 C) 3 D) 4 Correct Answer: A 65. What inhibits the enzyme Citrate Synthase? A) ATP B) ADP C) NAD+ D) FAD Correct Answer: A 66. Which molecule is NOT produced in the HMP pathway? A) ATP B) NADPH C) Ribose-5-Phosphate D) CO2  Correct Answer: A 67. What is the primary regulatory enzyme of the HMP Shunt? A) Citrate Synthase B) Glucose-6-Phosphate Dehydrogenase (G6PD) C) Pyruvate Kinase D) Transketolase Correct Answer: B 68. Which of the following tissues has high HMP activity due to fatty acid synthesis? A) Muscle B) Liver C) Brain D) Skin Correct Answer: B 69. What is the role of NADPH in erythrocytes? A) Protein synthesis B) Reduction of glutathione C) Glycolysis D) DNA synthesis Correct Answer: B 70. Which drug is NOT an oxidant drug causing hemolysis in G6PD deficiency? A) Primaquine B) Quinine C) Sulfamethoxazole D) Acetanilid Correct Answer: B 71. Where does the TCA cycle occur? A) Cytosol B) Mitochondria C) Nucleus D) Endoplasmic Reticulum Correct Answer: B 72. Which enzyme converts Pyruvate to Acetyl CoA? A) Citrate Synthase B) Pyruvate Dehydrogenase Complex (PDH) C) Isocitrate Dehydrogenase D) Lactate Dehydrogenase Correct Answer: B 73. Which condition is caused by thiamine deficiency affecting the PDH complex? A) Congenital Lactic Acidosis B) Wernicke's Encephalopathy C) Arsenic Poisoning D) Favism Correct Answer: B 74. How many ATP molecules are produced directly in one TCA cycle? A) 1 B) 2 C) 3 D) 4 Correct Answer: A 75. What inhibits the enzyme Citrate Synthase?  A) ATP B) ADP C) NAD+ D) FAD Correct Answer: A 76. Which molecule is NOT produced in the HMP pathway? A) ATP B) NADPH C) Ribose-5-Phosphate D) CO2 Correct Answer: A 77. What is the primary regulatory enzyme of the HMP Shunt? A) Citrate Synthase B) Glucose-6-Phosphate Dehydrogenase (G6PD) C) Pyruvate Kinase D) Transketolase Correct Answer: B 78. Which of the following tissues has high HMP activity due to fatty acid synthesis? A) Muscle B) Liver C) Brain D) Skin Correct Answer: B 79. What is the role of NADPH in erythrocytes? A) Protein synthesis  B) Reduction of glutathione C) Glycolysis D) DNA synthesis Correct Answer: B 80. Which drug is NOT an oxidant drug causing hemolysis in G6PD deficiency? A) Primaquine B) Quinine C) Sulfamethoxazole D) Acetanilid Correct Answer: B 81. Where does the TCA cycle occur? A) Cytosol B) Mitochondria C) Nucleus D) Endoplasmic Reticulum Correct Answer: B 82. Which enzyme converts Pyruvate to Acetyl CoA? A) Citrate Synthase B) Pyruvate Dehydrogenase Complex (PDH) C) Isocitrate Dehydrogenase D) Lactate Dehydrogenase Correct Answer: B 83. Which condition is caused by thiamine deficiency affecting the PDH complex? A) Congenital Lactic Acidosis B) Wernicke's Encephalopathy  C) Arsenic Poisoning D) Favism Correct Answer: B 84. How many ATP molecules are produced directly in one TCA cycle? A) 1 B) 2 C) 3 D) 4 Correct Answer: A 85. What inhibits the enzyme Citrate Synthase? A) ATP B) ADP C) NAD+ D) FAD Correct Answer: A 86. Which molecule is NOT produced in the HMP pathway? A) ATP B) NADPH C) Ribose-5-Phosphate D) CO2 Correct Answer: A 87. What is the primary regulatory enzyme of the HMP Shunt? A) Citrate Synthase B) Glucose-6-Phosphate Dehydrogenase (G6PD) C) Pyruvate Kinase  D) Transketolase Correct Answer: B 88. Which of the following tissues has high HMP activity due to fatty acid synthesis? A) Muscle B) Liver C) Brain D) Skin Correct Answer: B 89. What is the role of NADPH in erythrocytes? A) Protein synthesis B) Reduction of glutathione C) Glycolysis D) DNA synthesis Correct Answer: B 90. Which drug is NOT an oxidant drug causing hemolysis in G6PD deficiency? A) Primaquine B) Quinine C) Sulfamethoxazole D) Acetanilid Correct Answer: B 91. Where does the TCA cycle occur? A) Cytosol B) Mitochondria C) Nucleus D) Endoplasmic Reticulum  Correct Answer: B 92. Which enzyme converts Pyruvate to Acetyl CoA? A) Citrate Synthase B) Pyruvate Dehydrogenase Complex (PDH) C) Isocitrate Dehydrogenase D) Lactate Dehydrogenase Correct Answer: B 93. Which condition is caused by thiamine deficiency affecting the PDH complex? A) Congenital Lactic Acidosis B) Wernicke's Encephalopathy C) Arsenic Poisoning D) Favism Correct Answer: B 94. How many ATP molecules are produced directly in one TCA cycle? A) 1 B) 2 C) 3 D) 4 Correct Answer: A 95. What inhibits the enzyme Citrate Synthase? A) ATP B) ADP C) NAD+ D) FAD Correct Answer: A 96. Which molecule is NOT produced in the HMP pathway? A) ATP B) NADPH C) Ribose-5-Phosphate D) CO2 Correct Answer: A 97. What is the primary regulatory enzyme of the HMP Shunt? A) Citrate Synthase B) Glucose-6-Phosphate Dehydrogenase (G6PD) C) Pyruvate Kinase D) Transketolase Correct Answer: B 98. Which of the following tissues has high HMP activity due to fatty acid synthesis? A) Muscle B) Liver C) Brain D) Skin Correct Answer: B 99. What is the role of NADPH in erythrocytes? A) Protein synthesis B) Reduction of glutathione C) Glycolysis D) DNA synthesis Correct Answer: B 100. Which drug is NOT an oxidant drug causing hemolysis in G6PD deficiency? A) Primaquine B) Quinine C) Sulfamethoxazole D) Acetanilid Correct Answer: B