Podcast
Questions and Answers
Which molecule is produced in the HMP pathway?
Which molecule is produced in the HMP pathway?
- Ubiquinone
- GTP
- ATP
- NADPH (correct)
What is the effect of G6PD deficiency on the HMP pathway?
What is the effect of G6PD deficiency on the HMP pathway?
- Decreased NADPH levels (correct)
- Increased sorbitol production
- Enhanced fatty acid synthesis
- Increased production of ATP
Which tissue primarily utilizes the HMP pathway for nucleic acid synthesis?
Which tissue primarily utilizes the HMP pathway for nucleic acid synthesis?
- Muscle
- Adipose tissue
- Nervous tissue
- Liver (correct)
Which molecule is utilized by the Glucose-6-Phosphate Dehydrogenase enzyme in the HMP pathway?
Which molecule is utilized by the Glucose-6-Phosphate Dehydrogenase enzyme in the HMP pathway?
Which drug can cause oxidative stress in individuals with normal G6PD levels?
Which drug can cause oxidative stress in individuals with normal G6PD levels?
Which condition is linked to a deficiency of thiamine affecting the Pyruvate Dehydrogenase Complex?
Which condition is linked to a deficiency of thiamine affecting the Pyruvate Dehydrogenase Complex?
Which of the following enzymes plays a crucial role in regulating the HMP Shunt?
Which of the following enzymes plays a crucial role in regulating the HMP Shunt?
What is the main reason for the absence of ATP production in the HMP pathway?
What is the main reason for the absence of ATP production in the HMP pathway?
Which tissue has elevated HMP activity associated with its role in fatty acid synthesis?
Which tissue has elevated HMP activity associated with its role in fatty acid synthesis?
Which drug is most likely to be safe and not cause hemolysis in individuals with G6PD deficiency?
Which drug is most likely to be safe and not cause hemolysis in individuals with G6PD deficiency?
Flashcards
Location of TCA cycle
Location of TCA cycle
The TCA cycle occurs in the mitochondria.
Enzyme converting Pyruvate to Acetyl CoA
Enzyme converting Pyruvate to Acetyl CoA
Pyruvate Dehydrogenase Complex (PDH) converts pyruvate to acetyl CoA.
Thiamine deficiency symptom (PDH)
Thiamine deficiency symptom (PDH)
Thiamine deficiency affecting the PDH complex can cause Wernicke's encephalopathy.
ATP produced during one TCA cycle
ATP produced during one TCA cycle
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Inhibitor of Citrate Synthase
Inhibitor of Citrate Synthase
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HMP Shunt Regulatory Enzyme
HMP Shunt Regulatory Enzyme
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NADPH's Role in Erythrocytes
NADPH's Role in Erythrocytes
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TCA Cycle Location
TCA Cycle Location
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Pyruvate to Acetyl CoA Enzyme
Pyruvate to Acetyl CoA Enzyme
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TCA Cycle ATP Production
TCA Cycle ATP Production
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Study Notes
TCA Cycle and HMP Shunt - Study Notes
- TCA Cycle Location: The Tricarboxylic Acid (TCA) cycle occurs in the mitochondria.
- Pyruvate to Acetyl CoA Enzyme: The enzyme Pyruvate Dehydrogenase Complex (PDH) converts Pyruvate to Acetyl CoA.
- Thiamine Deficiency & PDH Complex: Wernicke's Encephalopathy is a condition caused by thiamine deficiency which affects the PDH complex.
- ATP Production in TCA Cycle: One turn of the TCA cycle directly produces one ATP molecule.
- Citrate Synthase Inhibitor: ATP inhibits the enzyme Citrate Synthase.
- HMP Pathway Molecule Exclusion: ATP is not produced in the HMP pathway.
- HMP Regulatory Enzyme: Glucose-6-Phosphate Dehydrogenase (G6PD) is the primary regulatory enzyme of the HMP shunt.
- High HMP Activity Tissue: Liver tissue has high HMP activity due to fatty acid synthesis.
- NADPH Role in Erythrocytes: NADPH in erythrocytes reduces glutathione.
- Oxidant Drug in G6PD Deficiency: Primaquine is an oxidant drug which can cause hemolysis in G6PD deficiency.
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Description
Explore the essential concepts of the TCA cycle and the HMP shunt in this comprehensive quiz. Learn about the enzymes involved, regulatory mechanisms, and the role of these metabolic pathways in cellular respiration and biosynthesis. Perfect for students in biochemistry or related fields.
