Sterilization Techniques in Hospital Pharmacy PDF

Sterilization Techniques in Hospital Pharmacy Sterilization is crucial for safe medication preparation in hospital pharmacies. It eliminates harmful microorganisms from drugs and equipment to prevent infection and ensure patient safety. by Uzair Ansari Importance of Sterile Compounding in Healt...

Sterilization Techniques in Hospital Pharmacy Sterilization is crucial for safe medication preparation in hospital pharmacies. It eliminates harmful microorganisms from drugs and equipment to prevent infection and ensure patient safety. by Uzair Ansari Importance of Sterile Compounding in Healthcare 1 Patient Safety 2 Drug Efficacy Sterile compounding Contamination can prevents infections degrade medications, caused by reducing their contaminated effectiveness. medications. 3 Compliance 4 Diverse Applications Sterile compounding Sterile products are adheres to regulatory used for various standards, ensuring treatments, including quality. IV therapy, ophthalmic solutions, and injections. Principles of Aseptic Technique 1 Environmental Control Maintaining a clean and controlled compounding environment is essential. This includes using HEPA filters and laminar airflow hoods. 2 Hand Hygiene Proper hand washing and using sterile gloves are crucial for preventing contamination. 3 Material Handling Carefully handling sterile materials and minimizing air exposure are critical for maintaining sterility. 4 Verification Regularly checking for potential contamination sources and monitoring sterility procedures is essential. Cleaning and Disinfection of the Compounding Daily Cleaning Disinfection Sterilization Routine cleaning involves Disinfection uses chemical Sterilization involves removing dust, debris, and agents to kill microorganisms eliminating all potential contaminants from on surfaces. It's typically done microorganisms, including surfaces. This includes wiping after daily cleaning and before spores. It's often used for down countertops, equipment, sterile compounding. equipment that comes in and floors. direct contact with sterile products. Gowning and Gloving Procedures Hand Hygiene Thoroughly wash hands with antimicrobial soap and water before donning a gown and gloves. Gown Put on a sterile gown, ensuring it covers your clothing completely, with the sleeves extending to your wrists. Gloves Don sterile gloves, carefully pulling them over the gown cuffs, avoiding contamination. Verification Double-check for any tears or punctures in the gown or gloves, ensuring sterilit Sterilization Methods Autoclaving Filtration Using high pressure and Passing solutions steam to sterilize through a membrane equipment and heat- filter to remove stable medications. microorganisms and particulate matter. Radiation Using gamma rays or electron beams to sterilize heat- sensitive medications and medical devices. Quality Control and Testing Sterility Testing Culturing samples to detect microbial growth. Endotoxin Testing Measuring the presence of bacterial endotoxins, which can cause fever. pH Testing Verifying the acidity or alkalinity of sterile solutions to ensure stability. Particle Counting Measuring the number of particles in sterile solutions to ensure cleanliness. Regulatory Requirements and Guidelines USP 797 FDA Guidance Sets standards for sterile Provides recommendations and compounding practices, emphasizing guidelines for sterile compounding, aseptic technique and environmental ensuring safe and effective drug controls. products. GMP Accreditation Good Manufacturing Practices apply Organizations like ASHP and USP to sterile compounding, ensuring offer accreditation programs to quality and consistency. recognize pharmacy facilities that meet quality standards for sterile compounding.