Creams in Pharmaceutical Dosage Forms PDF

# Cream - They form a foundation or base for powder. - On application over the skin, water evaporates, and stearic acid precipitates on the skin in finest crystals with considerable increase in smoothness of skin. - Stearic acid on precipitating acts as a base for applied powder. - Vanishing creams...

# Cream - They form a foundation or base for powder. - On application over the skin, water evaporates, and stearic acid precipitates on the skin in finest crystals with considerable increase in smoothness of skin. - Stearic acid on precipitating acts as a base for applied powder. - Vanishing creams are used during the day. # Collodions - Liquid topical preparation containing pyroxylin (nitrocellulose) in a mixture of ethyl ether & ethanol. - Salicylic acid collodions (USP 10%)= keratolytic & treat corns & warts (prolonged contact with the skin). # Pharmacy > It is the art and science of preparing and dispensing medications and the provision of drug-related information to the public # Drug or medicine - Is a substance or material, other than food intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in humans or animals; intended to affect the structure or any function of the body of humans or animals. # PHARMACEUTICAL DOSE FORMS | **1. Cachets.** | **16. Granules.** | **31. Pastes.** | | ---------------------- | ------------------------ | ------------------- | | **2. Capsules** | **17. Inhalations.** | **32. Pastilles.** | | **3. Collodions.** | **18. Implants.** | **33. Suppositories.** | | **4. Cold creams.** | **19. Insufflations.** | **34. Pessies.** | | **5. Vanishing creams.** | **20. Irrigation solutions.** | **35. Pills** | | **6. Draughts.** | **21. Linctuses.** | **36. Lauric** | | **7. Dusting powders.** | **22. Liniments.** | **37. Pressurized disp.** | | **8. Ear drops.** | **23. Lotions.** | **38. Pressurized inh.** | | **9. Elixirs.** | **24. Lozenges.** | **40. Sprays.** | | **10. Enemas.** | **25. Mixtures.** | **41. Solution tablets.** | | **11. Eye drops.** | **26. Mouth washes** | **42. Syrups.** | | **12. Eye lotions.** | **27. Nasal drops.** | **43. Tablets.** | | **13. Eye ointments** | **28. Ointments.** | | | **14. Gargles.** | **29. Paints.** | | | **15. Gels.** | **30. Parenteral preparations).** | | # Cachets - Powders container (0.2 to 1.5 g). - Made of rice flour and water. - Administration of nauseating drugs. - Diagram of a cachet with labels for "wet seal cachet" and "dry seal cachet" # Capsules - There are two types of capsule, "hard" and "soft". - Made gelatin which is filled with medicines to produce a unit dose. - Administration of nauseating drugs. - Diagram of a hard gelatin capsule with labels for "cap", "powder", and "body" - Diagram of a soft gelatin capsule labeled "liquid" # Cream - Topical preparation. - Cold or vanishing cream. - Cold cream is an emulsion of water in oil. ## Cold cream preparation - Melt beeswax with mineral oil in a porcelain dish over a water bath to about 75°C. - Dissolve borax & the two preservatives (methyl and propyl paraben) in water and heat the solution to 75°C. - Add 2 to 1 and stir slowly while still on the water bath for about 5 minutes, then remove the dish from the water bath and continue stirring slowly until the temperature drops to that of the room, then add the perfume. - Pour into jars. # Cream - Cold cream - Cleansing creams - Coloring creams # Cream ## Vanishing cream - It is o/w emulsion. - Disappear when rubbed into the skin. - Called foundation creams as they form a foundation base for powder. - Coloring creams. ### Formula for Vanishing cream | | | | --------------------------------------- | -------- | | Stearic acid | 15 g | | Glycerin | 5 g | | Potassium hydroxide | 0.72g | | Water | 79 g | | Methyl paraben | 0.2 g | | Propyl paraben | 0.02 g | | Perfume | Q.S. | | | Fiat cream. | # Cream ## Vanishing cream - Stearic acid is the oily phase. The emulsifier is soap (potassium stearate) which is formed *in situ* by adding KOH to neutralize a portion usually 20-30% of the free fatty acid (stearic acid). - Glycerin (humectant) help to improve the spreading properties of the cream and minimize the drying out of the cream on exposure to the air.