Rheumatology Past Papers PDF
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This document contains a set of past paper questions covering various topics in rheumatology. The questions cover different aspects of the subject from immunology to autoimmune diseases, and different types of arthritic conditions..
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1. Which of the following is correct? a. Adaptive immunity is found only in vertebrates b. Adaptive immunity is found only in invertebrates c. Innate immunity is found only in vertebrates d. Innate immunity is found only in invertebrates 2. Which of the following is correct? a....
1. Which of the following is correct? a. Adaptive immunity is found only in vertebrates b. Adaptive immunity is found only in invertebrates c. Innate immunity is found only in vertebrates d. Innate immunity is found only in invertebrates 2. Which of the following is correct? a. Innate immunity is found in both vertebrates and invertebrates b. Adaptive immunity is found only in invertebrates c. Innate immunity is found only in vertebrates d. Innate immunity is found only in invertebrates 3. Cells of the innate immune system include all of the following, except: a. Natural killer (NK) cell lymphocytes b. Monocytes/macrophages,neutrophils, basophils, eosinophils c. Dendritic cells, tissue mast cells, and epithelial cells d. B lymphocytes 4. What key properties does the normal immune system have? a. A highly diverse repertoire of antigen receptors that enables recognition of a nearly infinite range of pathogens; b. Immune memory, to mount rapid recall immune responses; c. Immunologic tolerance, to avoid immune damage to normal self-tissues d. all above is true 5. Which of the following is incorrect? a. The essential feature of an autoimmune disease is that tissue injury is caused by the immunologic reaction of the organism against its own tissues b. Autoimmunity is present in all individuals; c. The mechanisms of tissue injury in autoimmune diseases can be divided into antibody-mediated and cell-mediated processes. d. Abnormal immune responses require only endogenous abnormalities in the cells of the immune system and exogenous triggers are not important 6. Which of the following are the main directions in treatment of autoimmune diseases? a. Suppressing the induction of autoimmunity b. Restoring normal regulatory mechanisms c. Inhibiting the effector mechanisms d. all above is true 7. Which of the following is incorrect? a. Like many other autoimmune diseases, Rheumatoid arthritis (RA) occurs more commonly in females than in males b. RA affects the synovial tissue, underlying cartilage and bone c. Periarticular osteopenia occurs in joints with active inflammation d. RA is not systemic disease 8. Which of the following is correct? a. The incidence of RA increases between 65 and 85 years of age b. Patients often complain of early morning joint stiffness lasting more than 1 h that eases with physical activity c. The earliest involved joints are typically the large joints of the body d. Extraarticular manifestation is primary Sjogren's syndrome 9. Which of the following is true: Diagnosis of RA is largely based on signs and symptoms of: a. Chronic inflammatory arthritis b. Laboratory tests c. Radiographic results d. All above is true 10. Which of the following is correct for RA? a. Anti-CCP antibodies carry greater specificity for the diagnosis of RA b. IgM, IgG and IgA isotopes of RF (rheumatoid factor) occur in serum from patients with RA c. In synovial fluid white blood cell (WBC) counts can vary between 5000 and 50,000 d. All above is true 11. Which of the following is correct for Systemic Lupus Erythematosus (SLE)? a. SLE is an autoimmune disease b. 90% of patients are women of child-bearing years c. Interactions between susceptibility genes and environmental factors result in abnormal immune responses d. All above is true 12. Choose the correct answer for SLE: a. Gene-environment interactions result in abnormal immune responses b. Generated pathogenic autoantibodies and immune complexes deposit in tissues c. Activate complement cause inflammation d. Over time all of above lead to irreversible organ damage e. All above is true 13. Which of the following is incorrect for SLE: a. Histological abnormalities by biopsy may be found in the skin and kidney b. Deposition of Ig at the dermal-epidermal junction (DEJ) c. Clinically unaffected skin may also show Ig deposition at the DEJ d. The renal biopsies are not important in diagnosis and in selecting the best therapy 14. Which of the following if true: SLE clinical manifestations include: a. Cutaneous (Photosensitivity, Malar rash, oraI ulcers , alopecia, discoid rash, vasculitis rash) b. Hematologic (Anemia, Leukopenia, lymphopenia, thrombocytopenia, lymphadenopathy) c. Renal (Proteinuria>500 mg/24 h, nephrotic syndrome, end-stage renal disease) d. All above is true 15. Which of the following immunologic manifestation is not pathognomic for SLE? a. ANA > reference negative value b. Anti-ds DNA c. Anti-Sm d. Low serum complement e. Positive direct Coombs test f. Positive RF 16. Life-threatening SLE therapy include all, except: a. Systemic glucocorticoids b. Cyclophosphamide c. Azathioprine d. Mycophenolate e. NSAIDs 17. Which of the following is correct for systemic sclerosis (SS): a. "Mauskopf‘’ appearance with taut and shiny skin, loss of wrinkles b. An expressionless faces due to reduced mobility of the eyelids, cheek, and mouth c. Reduced oral aperture (microstomia) d. Thinning of the lips and fine wrinkles (radial furrowing) around the mouth e. All above is true 18. Which of the following is incorrect for Sjögren’s syndrome? a. It is a chronic, slowly progressive disease b. It is characterized by lymphocytic infiltration of the exocrine glands c. T lymphocyte hyperreactivity d. Diminished lacrimal and salivary gland function 19. Clinical manifestations of Sjögren’s syndrome include all of the following, except: a. Oral dryness (xerostomia) b. Difficulty in swallowing dry food c. Ability to speak continuously d. Burning sensation e. Increase in dental caries 20. Which of the following is incorrect for Spondyloarthritides (SA)? a. SA are a group of overlapping disorders that share certain clinical features b. SA is an autoimmune disease c. Ankylosing spondylitis (AS) is a one of the diseases in a group of spondyloarthritides d. SA are a group of overlapping disorders that share genetic associations 21. Which of the following is correct for Ankylosing spondylitis (AS)? AS is an inflammatory disorder that primarily affects: a. Axial skeleton b. Peripheral joints c. Extraarticular structures d. All above is true 22. Which of the following is incorrect for Ankylosing spondylitis (AS)? a. Male-to-female prevalence is between 2:1 and 3:1 b. Susceptibility to AS is not determined by genetic factors c. Sacroiliitis is often the earliest manifestation d. The pathogenesis of AS is immune-mediated 23. Which of the following is incorrect for Ankylosing spondylitis (AS)? a. The pathogenesis of AS is immune-mediated b. TNF-α plays a central role in the immunopathogenesis of AS c. Nocturnal exacerbation of pain often forces the patient to rest d. Wedging of thoracic vertebrae correlates with accentuated kyphosis 24. Which of the following is correct for vasculitis? a. Vasculitis is a clinicopathologic process characterized by inflammation of and damage to blood vessels b. It may be primary or secondary c. Genetic predisposition and environmental exposures are important d. All above is true 25. The most common clinical features of Sjögren’s syndrome include all of the following, except: a. The skin is covered with sweat b. Dry nose, throat, and trachea (xerotrachea) c. Esophageal mucosal atrophy d. Atrophic gastritis 26. SPONDYLOARTHRITIDES include all of the following, except: a. Rheumatoid arthritis (RA) b. Ankylosing spondylitis (AS) c. Reactive arthritis d. Psoriatic arthritis and spondylitis 27. Which of the following is correct for Ankylosing spondylitis (AS) ? AS primarily affects: a. Axial skeleton b. Peripheral joints c. Extraarticular structures d. All above is true 28. Which of the following is correct for pathology of Ankylosing spondylitis (AS) ? a. Sacroiliitis is often the earliest manifestation b. Eventually the eroded joint margins are gradually replaced by fibrocartilage regeneration and then by ossification c. The joint may become totally obliterated d. All above is true 29. Which of the following is correct for pathogenesis of Ankylosing spondylitis (AS) ? a. TNF-α plays a central role in the immunopathogenesis of AS b. Serum levels of IL-23 and IL- 1 7 are elevated in AS patients c. The inflamed sacroiliiac joint is infiltrated with CD4+ and CD8+ T cells and macrophages d. All above is true 30. Which of the following is correct for Ankylosing spondylitis (AS) ? a. Rheumatoid factor (RF) is elevated in 90% of patients b. Anti-cyclic citrullinated peptide (CCP) is elevated in 95% of patients c. No laboratory test is diagnostic of AS d. Antinuclear antibodies (ANAs) ) is elevated in 98% of patients