Pharmacology of the Reproductive System PDF
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Uploaded by NimbleCherryTree
Prof Suzanah Abdul Rahman
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Summary
This document presents lecture notes on the pharmacology of the reproductive system. The material covers various aspects, including the mechanism of action of different drugs, potential adverse effects, and indications for their usage. Several diagrams and figures enhance the understanding of the concepts.
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Pharmacology of the Reproductive System Prof Suzanah Abdul Rahman Recap MOA of Leuprolide ”start-up flare” *physiologic *infertility *Prostate cancer Uteri...
Pharmacology of the Reproductive System Prof Suzanah Abdul Rahman Recap MOA of Leuprolide ”start-up flare” *physiologic *infertility *Prostate cancer Uterine fibroid Endometriosis Toxicities: - Anti-androgenic effects - Nausea and vomiting Flutamide + leuprolide = for prostate cancer Sinus tachycardia Also hirsutism in on set of PCOS Benign prostatic hypertrophy (usage) Smooth muscle contraction Phospho-di-esterase 5 Nitric Oxide GTP Breaks down Cancel out cGMP If PDE5 is blocked, viagra GMP retained; ↑ blood flow, ↑ erection cause Smooth muscle relaxation Erectile dysfunction Toxicities: Headache Hypotension Flushing Dyspepsia Pulmonary arterial hypotension Contraindication: Nitrate + PDE5 = Life threatening hypotension Alternate name For male androgenic alopecia (male-patterned baldness) MOA of HRT: ↑ estrogen Which inhibit osteoclast activity Side effects: ↑ risk of breast cancer ↑ cardiovascular risk Vasomotor symptoms e.g. hot flashes, vaginal drying and pain Aromatase enzyme ↓ converts Androgen → estrogen *just fyi, according to author (can skip 3 last slides for revision)
